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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2010 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer

  • Authors:
    • Masahide Matsuyama
    • Rikio Yoshimura

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
  • Pages: 245-251
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/mmr_00000247
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Abstract

Leukotrienes (LTs) are biologically active fatty acids derived from the oxidative metabolism of arachidonic acid through the 5-lipoxygenase pathway. LTs work to contract airway smooth muscle, increase vascular permeability and mucus secretions, and attract and activate inflammatory cells in the airways of patients with asthma. Recently, it was reported that the LTD4 receptor (cysteinylLT1 receptor; CysLT1R) plays an important role in carcinogenesis. In this study, CysLT1R expression was examined in human urological cancer cell lines (renal cell carcinoma, bladder cancer, prostate cancer and testicular cancer) using immunohistochemistry and RT-PCR. The effect of CysLT1R antagonist on these cells was also examined using the MTT assay, Hoechst staining and flow cytometry. CysLT1R expression was significantly more extensive and intense in the malignant tissues than in normal tissues. Furthermore, CysLT1R antagonist induced a reduction in malignant cell viability through early apoptosis. These results demonstrate that CysLT1R expressed in urological cancer may play a crucial role in carcinogenesis. CysLT1R may therefore be a novel target in the treatment of urological cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuyama M and Yoshimura R: Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer . Mol Med Rep 3: 245-251, 2010.
APA
Matsuyama, M., & Yoshimura, R. (2010). Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer . Molecular Medicine Reports, 3, 245-251. https://doi.org/10.3892/mmr_00000247
MLA
Matsuyama, M., Yoshimura, R."Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer ". Molecular Medicine Reports 3.2 (2010): 245-251.
Chicago
Matsuyama, M., Yoshimura, R."Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer ". Molecular Medicine Reports 3, no. 2 (2010): 245-251. https://doi.org/10.3892/mmr_00000247
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuyama M and Yoshimura R: Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer . Mol Med Rep 3: 245-251, 2010.
APA
Matsuyama, M., & Yoshimura, R. (2010). Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer . Molecular Medicine Reports, 3, 245-251. https://doi.org/10.3892/mmr_00000247
MLA
Matsuyama, M., Yoshimura, R."Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer ". Molecular Medicine Reports 3.2 (2010): 245-251.
Chicago
Matsuyama, M., Yoshimura, R."Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer ". Molecular Medicine Reports 3, no. 2 (2010): 245-251. https://doi.org/10.3892/mmr_00000247
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