Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer

Xia,Xiao-Ming; Jin,Wei-Yun; Shi,Ren-Zhong; Zhang,Ya-Feng; Chen,Jun

doi:10.3892/ol.2010.164

November-December 2010 Volume 1 Issue 6

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November-December 2010 Volume 1 Issue 6

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Article

Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer

Authors:
- Xiao-Ming Xia
- Wei-Yun Jin
- Ren-Zhong Shi
- Ya-Feng Zhang
- Jun Chen
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Jinshan Branch of the Sixth People's Hospital, Affiliated with Shanghai Jiaotong University, Shanghai 201500, P.R. China, Department of Oncology, Jinshan Branch of the Sixth People's Hospital, Affiliated with Shanghai Jiaotong University, Shanghai 201500, P.R. China, Department of Pathology, Jinshan Branch of the Sixth People's Hospital, Affiliated with Shanghai Jiaotong University, Shanghai 201500, P.R. China
Pages: 1045-1048
|
Published online on: September 1, 2010

https://doi.org/10.3892/ol.2010.164
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Abstract

To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reaction. Our results using 31 NSCLC patient samples showed that 67.74% had a low let-7 expression (P<0.05), 64.52% had a high K-ras expression (P<0.05), and a significant correlation was observed between let-7 and K-ras gene expression (r=-0.6336) in tumor tissues. Patients with a low let-7 expression had a significantly shorter survival than those with a moderate let-7 expression (P<0.05). Patients with a high K-ras expression also had a significantly shorter survival than those with a moderate K-ras expression (P<0.05). In conclusion, a low expression of let-7 and a high expression of K-ras are correlated with the pathogenesis and prognosis of NSCLC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer

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