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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Novel disubstituted chrysene as a potent agent against colon cancer

  • Authors:
    • Bimal B. Banik
    • Manas K. Basu
    • Fredrick F. Becker
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, Texas 78539, USA, Department of Molecular Pathology, M. D. Anderson Cancer Center, Unit 951, The University of Texas, Houston, Texas 77030, USA
  • Pages: 1033-1036
    |
    Published online on: September 8, 2010
       https://doi.org/10.3892/ol.2010.167
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Abstract

Research on polycyclic aromatic hydrocarbons and their derivatives has received significant attention from the scientific community. The present study involved the synthesis of several novel 6,12-disubstituted chrysene derivatives. Nitration of chrysene with nitric acid produced 6,12-dinitrochrysene which when reduced yielded 6,12-diaminochrysene. A coupling reaction of 6,12-diaminochrysene with an acid in the presence of isobutylchloroformate produced amide. The reduction of amide produced an amine. The amino was converted to a hydrochloride salt. The new compounds were characterized through different types of analytical data. One of these compounds demonstrated marked activity in vivo against a colon cancer cell line. Inhibition of the growth of this tumor was best noted at day 20 when each treatment regimen inhibited the average tumor volume by 50%. In a number of in vivo tests in various regimens, the hydrochloride salt demonstrated consistent inhibition of the growth of the cancer HT-29 cell line. Despite the research progress in polycyclic aromatic compounds, the use of these types of molecules as anticancer agents has not been reported systematically.
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Copy and paste a formatted citation
Spandidos Publications style
Banik BB, Basu MK and Becker FF: Novel disubstituted chrysene as a potent agent against colon cancer. Oncol Lett 1: 1033-1036, 2010.
APA
Banik, B.B., Basu, M.K., & Becker, F.F. (2010). Novel disubstituted chrysene as a potent agent against colon cancer. Oncology Letters, 1, 1033-1036. https://doi.org/10.3892/ol.2010.167
MLA
Banik, B. B., Basu, M. K., Becker, F. F."Novel disubstituted chrysene as a potent agent against colon cancer". Oncology Letters 1.6 (2010): 1033-1036.
Chicago
Banik, B. B., Basu, M. K., Becker, F. F."Novel disubstituted chrysene as a potent agent against colon cancer". Oncology Letters 1, no. 6 (2010): 1033-1036. https://doi.org/10.3892/ol.2010.167
Copy and paste a formatted citation
x
Spandidos Publications style
Banik BB, Basu MK and Becker FF: Novel disubstituted chrysene as a potent agent against colon cancer. Oncol Lett 1: 1033-1036, 2010.
APA
Banik, B.B., Basu, M.K., & Becker, F.F. (2010). Novel disubstituted chrysene as a potent agent against colon cancer. Oncology Letters, 1, 1033-1036. https://doi.org/10.3892/ol.2010.167
MLA
Banik, B. B., Basu, M. K., Becker, F. F."Novel disubstituted chrysene as a potent agent against colon cancer". Oncology Letters 1.6 (2010): 1033-1036.
Chicago
Banik, B. B., Basu, M. K., Becker, F. F."Novel disubstituted chrysene as a potent agent against colon cancer". Oncology Letters 1, no. 6 (2010): 1033-1036. https://doi.org/10.3892/ol.2010.167
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