Inhibition of pleural metastasis of collecting duct carcinoma of the kidney by modified cytokine-induced killer cells: A case report and review of the literature

Liu,Jingyi; Sui,Jun; Zhang,Zhiwei; Ren,Xiubao; Luan,Li; Yang,Qisheng; Gu,Songhai; Wank,Rudolf; Laumbacher,Barbara; Song,Xin

doi:10.3892/ol.2010.168

November-December 2010 Volume 1 Issue 6

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November-December 2010 Volume 1 Issue 6

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Case Report

Inhibition of pleural metastasis of collecting duct carcinoma of the kidney by modified cytokine-induced killer cells: A case report and review of the literature

Authors:
- Jingyi Liu
- Jun Sui
- Zhiwei Zhang
- Xiubao Ren
- Li Luan
- Qisheng Yang
- Songhai Gu
- Rudolf Wank
- Barbara Laumbacher
- Xin Song
View Affiliations / Copyright

Affiliations: Cancer Biotherapy Center, the Third Affiliated Hospital, Kunming Medical College, Kunming 650118, P.R. China, Department of Biotherapy, the Affiliated Cancer Hospital, Tianjin Medical University, Tianjin, P.R. China, Radiology Department, the Third Affiliated Hospital, Kunming Medical College, Kunming, P.R. China, Immunotherapy Research Centre, D-80336 Munich, Germany
Pages: 955-958
|
Published online on: September 8, 2010

https://doi.org/10.3892/ol.2010.168
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Abstract

Collecting duct carcinoma (CDC) or Bellini duct carcinoma of the kidney is a rare, but highly aggressive renal epithelial malignancy, with an extremely poor prognosis. Modified cytokine-induced killer (mCIK) cells were injected into the pleural cavity to treat pleural metastasis of CDC. The patient, a 33-year-old male, was admitted to hospital for further treatment for severe pleural metastasis of CDC. We cured the pleural metastasis through intrapleural infusion with mCIK cells. After receiving this innovative treatment, the patient exhibited a positive response: the cough, dyspnea, chest distress and thoracalgia were evidently relieved, while the pleural fluid became clear after exhibiting haematodes and its level decreased significantly. The patient achieved partial success. This novel immunotherapy method is a promising treatment for patients with refractory pleural metastasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibition of pleural metastasis of collecting duct carcinoma of the kidney by modified cytokine-induced killer cells: A case report and review of the literature

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