Myoepithelial carcinoma of the parotid gland with bilateral thyroid involvement: A case report and review of the literature

Zhang,Lei; Wang,Dianjun; Ren,Yipeng; Feng,Jin; Bu,Rongfa

doi:10.3892/ol.2010.174

November-December 2010 Volume 1 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-December 2010 Volume 1 Issue 6

Full Size Image

Case Report

Myoepithelial carcinoma of the parotid gland with bilateral thyroid involvement: A case report and review of the literature

Authors:
- Lei Zhang
- Dianjun Wang
- Yipeng Ren
- Jin Feng
- Rongfa Bu
View Affiliations / Copyright

Affiliations: Department of Oral and Maxillofacial Surgery, The Chinese PLA General Hospital, The Stomatological Institute of Chinese PLA, Beijing 100853, P.R. China, Department of Pathology, The Chinese PLA General Hospital, Beijing 100853, P.R.China
Pages: 1079-1082
|
Published online on: September 22, 2010

https://doi.org/10.3892/ol.2010.174
Expand metrics +

Abstract

A patient was admitted to hospital with enlarged lobes of the thyroid gland with bilateral cervical lymph node involvement, and surgical excision followed. Histological examination of this specimen revealed a lesion that showed myoepithelial cell differentiation. Primary thyroid and skin appendage tumors were excluded based on clinical examination, conventional histology and immunohistochemistry. A tumor of the right parotid surgically treated in June 2008, approximately 2 years previously, was originally classified as a basal cell adenocarcinoma with focal invasion, but was re-examined. Using immunohistochemistry, the parotid tumor was re-classified as a myoepithelial carcinoma. The thyroid tumor proved to be metastasis from a primary parotid tumor, which was not found in the updated review of the literature. The literature is reviewed, including current knowledge on the histological and immunohistochemical features of myoepithelial carcinoma, with limited data on treatment suggestions.

View Figures

View References

1	Nagao T, Sugano I, Ishida Y, Tajima Y, Matsuzaki O, Konno A, Kondo Y and Nagao K: Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer. 83:1292–1299. 1998. View Article : Google Scholar : PubMed/NCBI
2	Di Palma S and Guzzo M: Malignant myoepithelioma of salivary glands: clinicopathological features of ten cases. Virchows Arch A Pathol Anat Histopathol. 423:389–396. 1993.PubMed/NCBI
3	Savera AT, Sloman A, Huvos AG and Klimstra DS, Huvos AG and Klimstra DS: Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol. 24:761–774. 2000. View Article : Google Scholar : PubMed/NCBI
4	Cheuk W and Chan JK: Advances in salivary gland pathology. Histopathology. 51:1–20. 2007. View Article : Google Scholar
5	Wang Z, Herrington B, Schwartz MR and Laucirica R: Myoepithelial carcinoma of the parotid gland metastatic to the kidney: case report and review of the literature. Diagn Cytopathol. 38:27–282. 2010.
6	Chhieng DC and Paulino AF: Cytology of myoepithelial carcinoma of the salivary gland. Cancer. 96:32–36. 2002. View Article : Google Scholar : PubMed/NCBI
7	Hornick JL and Fletcher CD: Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 27:1183–1196. 2003. View Article : Google Scholar : PubMed/NCBI
8	Seifert G and Sobin LH: Histological typing of salivary gland tumors. World Health Organization International Histological Classification of Tumors. 2nd edition. Springer-Verlag; NY: 1991
9	Darvishian F and Lin O: Myoepithelial cell-rich neoplasms cytologic features of benign and malignant lesions. Cancer. 102:355–361. 2004. View Article : Google Scholar : PubMed/NCBI
10	Seethala RR, Barnes EL and Hunt JL: Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 31:44–56. 2007. View Article : Google Scholar
11	Wang B, Brandwein M, Gordon R, Robinson R, Urken M and Zarbo RJ: Primary salivary clear cell tumors – a diagnostic approach a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Arch Pathol Lab Med. 126:676–685. 2002.
12	Ogawa I, Nishida T, Miyauchi M, Sato S and Takata T: Dedifferentiated malignant myoepithelioma of the parotid gland. Pathol Int. 53:704–709. 2003. View Article : Google Scholar : PubMed/NCBI
13	Jain M, Thomas S and Singh S: Epithelial myoepitheial carcinoma of minor salivary gland – low grade malignant tumor presenting with nodal metastasis. Indian J Pathol Microbiol. 49:399–401. 2006.PubMed/NCBI
14	Genelhu MC, Gobbi H, Soares FA, Campos AH, Ribeiro CA and Cassali GD: Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. Oral Oncol. 42:154–160. 2006. View Article : Google Scholar : PubMed/NCBI
15	Edwards PC, Bhuiya T and Kelsch RD: Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canicular adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 97:613–619. 2004. View Article : Google Scholar
16	Bilal H, Handra-Luca A, Bertrand JC and Fouret PJ: p63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues. J Histochem Cytochem. 51:133–139. 2003. View Article : Google Scholar : PubMed/NCBI
17	Emanuel P, Wang B, Wu M and Burstein DA: p63 immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol. 18:645–650. 2005. View Article : Google Scholar : PubMed/NCBI
18	Furuse C, Sousa SO, Nunes FD, Magalhães MH and Araújo VC: Myoepithelial cell markers in salivary gland neoplasms. Int J Surg Pathol. 13:57–65. 2005. View Article : Google Scholar : PubMed/NCBI
19	Kane SV and Bagwan IN: Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 51 cases in a tertiary cancer center. Arch Otolaryngol Head Neck Surg. 136:702–712. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Myoepithelial carcinoma of the parotid gland with bilateral thyroid involvement: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles