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Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy

  • Authors:
    • Itaru Chiba
    • Kazuhiko Ogawa
    • Takamitsu Morioka
    • Hideaki Shimoji
    • Nao Sunagawa
    • Shiro Iraha
    • Tadashi Nishimaki
    • Naomi Yoshimi
    • Sadayuki Murayama
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, University of the Ryukyus School of Medicine, Okinawa 903-0215, Japan, Department of Pathology, University of the Ryukyus School of Medicine, Okinawa 903-0215, Japan, Department of Surgery, University of the Ryukyus School of Medicine, Okinawa 903-0215, Japan
  • Pages: 21-28
    |
    Published online on: October 27, 2010
       https://doi.org/10.3892/ol.2010.199
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Abstract

This study aimed to investigate whether glucose transporter-1 (GLUT-1) expression in a pretreatment esophageal cancer biopsy was predictive of clinical outcomes in patients with esophageal cancer undergoing concurrent chemoradiotherapy (CRT). A total of 25 patients with esophageal cancer treated with concurrent CRT were reviewed. Radiotherapy was administered up to total doses of 40-66.6 Gy (median 66.6 Gy) with a single fraction of 1.8-2 Gy. Regarding chemotherapy, cisplatin (80 mg/m2 on day 1) and 5-fluorouracil (800 mg/m2 on days 2-6) were used concurrently with radiotherapy, every 3-4 weeks for a total of 1-2 courses. Tissue samples from esophageal carcinoma were obtained from the 25 patients by biopsy prior to concurrent CRT, and a semiquantitative analysis of GLUT-1 expression was performed using immunohistochemical staining. High GLUT-1 expression was observed in 7 of 25 (28%) patients, and GLUT-1 expression was significantly correlated with clinical T stage (p=0.0454), clinical N stage (p=0.0324) and initial response to CRT (p=0.0185). Patients with a high GLUT-1 expression had significantly poorer local control (LC) (5-year LC 28.6%) than those with a low expression (5-year LC 73.4%, p<005). Multivariate analysis revealed that GLUT-1 and the number of chemotherapy courses were independent prognostic factors for LC. Patients with a high GLUT-1 expression had significantly lower recurrence-free survival (RFS) compared to those with a low GLUT-1 expression (p=0.0405). Multivariate analysis revealed that GLUT-1, the number of chemotherapy courses and clinical M stage were independent prognostic factors for RFS. GLUT-1 expression was significantly correlated with clinical T stage, clinical N stage and initial response to concurrent CRT, and was predictive of LC and RFS for patients with esophageal cancer treated with concurrent CRT.
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Copy and paste a formatted citation
Spandidos Publications style
Chiba I, Ogawa K, Morioka T, Shimoji H, Sunagawa N, Iraha S, Nishimaki T, Yoshimi N and Murayama S: Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy. Oncol Lett 2: 21-28, 2011.
APA
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S. ... Murayama, S. (2011). Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy. Oncology Letters, 2, 21-28. https://doi.org/10.3892/ol.2010.199
MLA
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S., Nishimaki, T., Yoshimi, N., Murayama, S."Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy". Oncology Letters 2.1 (2011): 21-28.
Chicago
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S., Nishimaki, T., Yoshimi, N., Murayama, S."Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy". Oncology Letters 2, no. 1 (2011): 21-28. https://doi.org/10.3892/ol.2010.199
Copy and paste a formatted citation
x
Spandidos Publications style
Chiba I, Ogawa K, Morioka T, Shimoji H, Sunagawa N, Iraha S, Nishimaki T, Yoshimi N and Murayama S: Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy. Oncol Lett 2: 21-28, 2011.
APA
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S. ... Murayama, S. (2011). Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy. Oncology Letters, 2, 21-28. https://doi.org/10.3892/ol.2010.199
MLA
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S., Nishimaki, T., Yoshimi, N., Murayama, S."Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy". Oncology Letters 2.1 (2011): 21-28.
Chicago
Chiba, I., Ogawa, K., Morioka, T., Shimoji, H., Sunagawa, N., Iraha, S., Nishimaki, T., Yoshimi, N., Murayama, S."Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy". Oncology Letters 2, no. 1 (2011): 21-28. https://doi.org/10.3892/ol.2010.199
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