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Article

Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer

  • Authors:
    • Masachika Senba
    • Nathan Buziba
    • Naoki Mori
    • Shuichi Fujita
    • Konosuke Morimoto
    • Akihiro Wada
    • Kan Toriyama
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan, Department of Hematology and Blood Transfusion, Faculty of Health Science, Moi University, Eldoret, Kenya, Department of Internal Medicine, Omoromachi Medical Center, Okinawa 900-0011, Japan, Division of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan, Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan, Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan, Department of Pathology, Japanese Red-Cross Nagasaki Atomic Bomb Hospital, Nagasaki 852-8511, Japan
  • Pages: 65-68
    |
    Published online on: November 23, 2010
       https://doi.org/10.3892/ol.2010.207
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Abstract

This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identified using in situ hybridization. Of the 62 cases, HPV infection was detected in 28 (45.2%). This frequency was lower than in penile cancer (68.2%) as shown by our previous study. The earliest age of onset of cervical and penile cancer was 18 and 35, respectively, whereas the mean age of the initial diagnosis of cervical and penile cancer was 50.1 and 59.6, respectively. The discrepancies of HPV prevalence, earliest ages of onset and mean ages between cervical and penile cancer patients may result from the gender-based synergistic action of HPV associated with multiple epidemiological co-factors. Of the 28 HPV-infected cases, NF-κB expression was observed in the nucleus in 18 (64.3%), in the cytoplasm in 19 (67.9%) and in the nucleus and/or cytoplasm in 27 cases (96.4%). The overexpression of NF-κB in cervical cancer cases suggests that NF-κB activation is a key modulator in driving chronic inflammation to cancer.
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1 

Hausen H: Papillomaviruses in the causation of human cancers – a brief histological account. Virology. 44:219–224. 2009.

2 

Senba M, Mori N and Wada A: Oncogenesis of human papilomavirus (HPV). DNA Tumor Virus. Tao HE: Nova Science Publishers Inc.; New York: pp. 75–102. 2009

3 

Senba M, Mori N and Wada A: Oncogenesis and the link between inflammation and cancer due to human papillomavirus (HPV) infection, and the development of vaccine control strategies. Cancer Res J. 2:307–338. 2009.

4 

Smith JS, Herrero R, Bosetti C, et al: Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst. 94:1604–1613. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Smith JS, Munoz N, Herrero R, et al: Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines. J Infect Dis. 185:324–331. 2002.

6 

Karin M and Greten FR: NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005.

7 

Karin M: Nuclear factor-κB in cancer development and progression. Nature. 441:749–759. 2006.

8 

Kiriakidis S, Andreakos E, Monaco C, et al: VEGF expression in human macrophages is NF-κB-dependent: studies using adenoviruses expressing the endogenous NF-κB inhibitor IκBα and kinase-defective form of the IκB kinase 2. J Cell Sci. 116:665–674. 2003.

9 

Senba M, Kumatori A, Fujita S, et al: The prevalence of human papillomavirus genotypes in penile cancers from northern Thailand. J Med Virol. 78:1341–1346. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Fujita S, Senba M, Kumatori A, et al: Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression. Pathobiology. 75:257–264. 2008. View Article : Google Scholar

11 

Senba M, Mori N, Wada A, et al: Human papillomavirus genotypes in penile cancers from Japanese patients and NF-κB activation. Oncol Lett. 1:267–272. 2010.PubMed/NCBI

12 

Senba M, Buziba N, Mori N, et al: Detection of human papillomavirus and cellular regulators p16INK4a, p53, and NF-κB in penile cancer cases in Kenya. Acta Virol. 53:43–48. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Espey DK, Wu XC, Swan J, et al: Annual report to the nation on the status of cancer, 1975–2004, featuring cancer in American Indians and Alaska natives. Cancer. 110:2119–2152. 2007.

14 

Parkin DM and Bray F: The burden of HPV-related cancers. Vaccine. 24(Suppl 3): 11–25. 2006. View Article : Google Scholar

15 

Bryan JT, Taddeo F, Skulsky D, et al: Detection of specific human papillomavirus types in paraffin-embedded sections of cervical carcinomas. J Med Virol. 78:117–124. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Louie KS, Sanjose S and Mayaud P: Epidemiology and prevention of human papillomavirus and cervical cancer in sub-Sahara Africa: a comprehensive review. Trop Med Int Health. 14:1287–1302. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Yamada R, Sasagawa T, Kirumbi LW, et al: Human papillomavirus infection and cervical abnormalities in Nairobi, Kenya, an area with a high prevalence of human immunodeficiency virus infection. J Med Virol. 80:847–855. 2008. View Article : Google Scholar

18 

Nees M, Geoghegan JM, Hyman T, et al: Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-κB-responsive genes in cervical keratinocytes. J Virol. 75:4283–4296. 2001.PubMed/NCBI

19 

Spitkovsky D, Hehner SP, Hofmann TG, et al: The human papillomavirus oncoprotein E7 attenuates NF-κB activation by targeting IκB kinase complex. J Biol Chem. 277:25576–25582. 2002.PubMed/NCBI

20 

Havard L, Delvenne P, Frare P, et al: Differential production of cytokines and activation of NF-κB in HPV transformed keratinocytes. Virology. 298:271–285. 2002.

21 

Havard L, Rahmouni S, Boniver J, et al: High levels of p105 (NF-κB1) and p100 (NF-κB2) proteins in HPV 16-transformed keratinocytes. Virology. 331:357–366. 2005.

22 

Mishra A, Bharti AC, Varghese P, et al: Differential expression and activation of NF-κB family proteins during oral carcinogenesis: role of high risk human papillomavirus infection. Int J Cancer. 119:2840–2850. 2006.

23 

James MA, Lee JH and Klingelhutz AJ: Human papillomavirus type 16 E6 activates NF-κB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. J Virol. 80:5301–5307. 2006.

24 

Senba M, Mori N, Fujita S, et al: Relationship among human papillomavirus infection, p16INK4a, p53 and NF-κB activation in penile cancer from northern Thailand. Oncol Lett. 1:599–603. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Munger K, Baldwin A, Edwards KM, et al: Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 78:11451–11460. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Senba M, Buziba N, Mori N, Fujita S, Morimoto K, Wada A and Toriyama K: Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer. Oncol Lett 2: 65-68, 2011.
APA
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., & Toriyama, K. (2011). Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer. Oncology Letters, 2, 65-68. https://doi.org/10.3892/ol.2010.207
MLA
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., Toriyama, K."Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer". Oncology Letters 2.1 (2011): 65-68.
Chicago
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., Toriyama, K."Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer". Oncology Letters 2, no. 1 (2011): 65-68. https://doi.org/10.3892/ol.2010.207
Copy and paste a formatted citation
x
Spandidos Publications style
Senba M, Buziba N, Mori N, Fujita S, Morimoto K, Wada A and Toriyama K: Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer. Oncol Lett 2: 65-68, 2011.
APA
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., & Toriyama, K. (2011). Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer. Oncology Letters, 2, 65-68. https://doi.org/10.3892/ol.2010.207
MLA
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., Toriyama, K."Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer". Oncology Letters 2.1 (2011): 65-68.
Chicago
Senba, M., Buziba, N., Mori, N., Fujita, S., Morimoto, K., Wada, A., Toriyama, K."Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer". Oncology Letters 2, no. 1 (2011): 65-68. https://doi.org/10.3892/ol.2010.207
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