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Article

Zeranol may increase the risk of leptin-induced neoplasia in human breast

  • Authors:
    • Pingping Xu
    • Weiping Ye
    • Saiyi Zhong
    • Robert Jen
    • Hong Li
    • Eric Feng
    • Shu-Hong Lin
    • Jie-Yu Liu
    • Young C. Lin
  • View Affiliations / Copyright

    Affiliations: Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
  • Pages: 101-108
    |
    Published online on: November 23, 2010
       https://doi.org/10.3892/ol.2010.214
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Abstract

Breast cancer and obesity are serious health problems and their relationship has been studied for many years. Leptin is mainly secreted by adipocytes and plays a key role in breast cancer development. Leptin expression is up-regulated in obese individuals and promotes breast cancer cell growth. On the other hand, exposure to environmental estrogens has been found to be directly related to breast cancer. Zeranol (Z) is a non-steroidal anabolic growth promoter used in the beef industry in the US. This study focused on the evaluation of Z and Z-containing sera (ZS) and its adverse health risk to human consumption of Z-containing meat produced from Z-implanted beef cattle. We hypothesized that Z increases the risk of breast neoplasia in women, particularly in obese women. A cell proliferation assay, ELISA analysis, RT-PCR and Western blot analysis were conducted. Our study demonstrated that Z and ZS collected from Z-implanted heifers stimulated the proliferation of primary cultured human normal breast epithelial cells (HNBECs) by up-regulating cyclin D1 expression. Leptin increased the sensitivity of HNBECs to Z, and Z increased the ability of HNBECs to secrete leptin. These results suggest an interaction between leptin and Z in HNBECs. Furthermore, Z may play a role in leptin-induced breast neoplasia.
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Copy and paste a formatted citation
Spandidos Publications style
Xu P, Ye W, Zhong S, Jen R, Li H, Feng E, Lin S, Liu J and Lin YC: Zeranol may increase the risk of leptin-induced neoplasia in human breast. Oncol Lett 2: 101-108, 2011.
APA
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E. ... Lin, Y.C. (2011). Zeranol may increase the risk of leptin-induced neoplasia in human breast. Oncology Letters, 2, 101-108. https://doi.org/10.3892/ol.2010.214
MLA
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E., Lin, S., Liu, J., Lin, Y. C."Zeranol may increase the risk of leptin-induced neoplasia in human breast". Oncology Letters 2.1 (2011): 101-108.
Chicago
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E., Lin, S., Liu, J., Lin, Y. C."Zeranol may increase the risk of leptin-induced neoplasia in human breast". Oncology Letters 2, no. 1 (2011): 101-108. https://doi.org/10.3892/ol.2010.214
Copy and paste a formatted citation
x
Spandidos Publications style
Xu P, Ye W, Zhong S, Jen R, Li H, Feng E, Lin S, Liu J and Lin YC: Zeranol may increase the risk of leptin-induced neoplasia in human breast. Oncol Lett 2: 101-108, 2011.
APA
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E. ... Lin, Y.C. (2011). Zeranol may increase the risk of leptin-induced neoplasia in human breast. Oncology Letters, 2, 101-108. https://doi.org/10.3892/ol.2010.214
MLA
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E., Lin, S., Liu, J., Lin, Y. C."Zeranol may increase the risk of leptin-induced neoplasia in human breast". Oncology Letters 2.1 (2011): 101-108.
Chicago
Xu, P., Ye, W., Zhong, S., Jen, R., Li, H., Feng, E., Lin, S., Liu, J., Lin, Y. C."Zeranol may increase the risk of leptin-induced neoplasia in human breast". Oncology Letters 2, no. 1 (2011): 101-108. https://doi.org/10.3892/ol.2010.214
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