IgM multiple myeloma presenting with bleeding tendency: a case report with immunophenotype analysis

Zheng,Ling; Zeng,Zhiyong; Lin,Junfang; Chen,Junmin

doi:10.3892/ol.2010.216

January-February 2011 Volume 2 Issue 1

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January-February 2011 Volume 2 Issue 1

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Case Report

IgM multiple myeloma presenting with bleeding tendency: a case report with immunophenotype analysis

Authors:
- Ling Zheng
- Zhiyong Zeng
- Junfang Lin
- Junmin Chen
View Affiliations / Copyright

Affiliations: Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China
Pages: 55-57
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Published online on: November 23, 2010

https://doi.org/10.3892/ol.2010.216
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Abstract

IgM multiple myeloma (MM) is an extremely rare lymphoproliferative disease associated with an aggressive clinical course. However, the diagnosis of IgM MM may be complicated by Waldenstrom's macroglobulinemia (WM), particularly when clinical manifestations and morphological features are not typical. It is crucial to distinguish between IgM MM and WM as their prognoses and treatment strategies are different. We report a case of IgM MM presenting with bleeding tendency and an immunophenotype analysis using flow cytometry and immunohistochemistry. Bone marrow cells exhibited a typical phenotype for plasma cells, expressing monoclonal cytoplasmatic IgL-λ, CD38 and CD138 instead of pan-B cell antigens CD19, CD20 and CD22, which are characteristic of the typical immunophenotype of WM. Therefore, the diagnosis of IgM MM was confirmed in this case, highlighting the significance of detailed immuno-phenotypic evaluation when clinical and morphological features are atypical.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

IgM multiple myeloma presenting with bleeding tendency: a case report with immunophenotype analysis

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