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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma

  • Authors:
    • Lu Feng
    • Mei Li
    • Qiu-Ping Zhang
    • Zheng-Ai Piao
    • Zhao-Hui Wang
    • Shen Lv
  • View Affiliations / Copyright

    Affiliations: Laboratory Center, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116027, P.R. China, Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Liaoning 116011, P.R. China, Department of Pathology, The Third People's Hospital of Dalian, Liaoning 116033, P.R. China
  • Pages: 59-63
    |
    Published online on: November 23, 2010
       https://doi.org/10.3892/ol.2010.219
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Abstract

V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a significant member of the MAPK pathway, the point mutation (V600E) of which is a common genetic event in papillary thyroid carcinoma (PTC). Investigators showed that the variations in BRAF expression levels were independent of the V600E mutation. These variations were involved in the pathogenesis of thyroid carcinomas. This study evaluated the feasibility of BRAF, proliferating cell nuclear antigen (PCNA) and hMSH2 as markers for the prediction of the metastatic potential of PTC. Using immunohistochemistry, the expression of BRAF, PCNA and hMSH2 proteins was studied in 70 PTC and 29 nodular goiter (NG) tissues. The results indicated that i) the positive rate of BRAF, PCNA and hMSH2 expression in PTCs was significantly higher than that in NGs (P=0.000, P=0.000 and P=0.003, respectively), ii) the positive rate of BRAF expression in the lymph node metastasis (LNM) group was significantly higher than that in the non-LNM group (P=0.019), iii) the age at diagnosis of PTC patients with LNM was significantly older compared to that without LNM (P=0.021) and iv) the positive rate of BRAF expression significantly correlated with that of PCNA and hMSH2 expression (P=0.000 and P=0.019, respectively). In conclusion, BRAF, PCNA and hMSH2 overexpression appeared to be molecular events of PTC carcinogenesis. Older patients with BRAF overexpression appear to be a high-risk group for PTC metastasis. Detection of BRAF expression is likely to aid in the prediction of the metastatic potential of the carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Feng L, Li M, Zhang Q, Piao Z, Wang Z and Lv S: Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma. Oncol Lett 2: 59-63, 2011.
APA
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., & Lv, S. (2011). Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma. Oncology Letters, 2, 59-63. https://doi.org/10.3892/ol.2010.219
MLA
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., Lv, S."Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma". Oncology Letters 2.1 (2011): 59-63.
Chicago
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., Lv, S."Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma". Oncology Letters 2, no. 1 (2011): 59-63. https://doi.org/10.3892/ol.2010.219
Copy and paste a formatted citation
x
Spandidos Publications style
Feng L, Li M, Zhang Q, Piao Z, Wang Z and Lv S: Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma. Oncol Lett 2: 59-63, 2011.
APA
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., & Lv, S. (2011). Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma. Oncology Letters, 2, 59-63. https://doi.org/10.3892/ol.2010.219
MLA
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., Lv, S."Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma". Oncology Letters 2.1 (2011): 59-63.
Chicago
Feng, L., Li, M., Zhang, Q., Piao, Z., Wang, Z., Lv, S."Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma". Oncology Letters 2, no. 1 (2011): 59-63. https://doi.org/10.3892/ol.2010.219
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