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Article

Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration

  • Authors:
    • Naohide Oue
    • Tsuyoshi Noguchi
    • Katsuhiro Anami
    • Kazuhiro Sentani
    • Naoya Sakamoto
    • Naohiro Uraoka
    • Yuta Wakamatsu
    • Hiroki Sasaki
    • Wataru Yasui
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan, Department of Gastrointestinal Surgery, Oita University Faculty of Medicine, Oita, Japan, Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
  • Pages: 235-239
    |
    Published online on: January 19, 2011
       https://doi.org/10.3892/ol.2011.239
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Abstract

Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immunostaining and the Reg IV levels in sera were measured from 65 patients with esophageal squamous cell carcinoma (SCC) by enzyme-linked immunosorbent assay. No Reg IV staining was detected in 255 SCC and 4 small cell carcinoma samples, whereas Reg IV was stained in 4 of 10 (40%) adenocarcinoma samples. Serum Reg IV concentration in esophageal SCC patients was significantly higher compared to that of the control subjects (P=0.0003). A significant correlation between serum Reg IV concentration and age was found in control subjects (P<0.0001). When serum Reg IV concentration was analyzed according to age, the distribution of serum Reg IV concentration in patients with esophageal SCC was similar to that of the control subjects. These results suggest that Reg IV expression is highly specific for adenocarcinoma of the esophagus. Further investigation is required to clarify whether Reg IV serves as a serum tumor marker for esophageal cancer.
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Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H and Yasui W: Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

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Sentani K, Oue N, Tashiro T, Sakamoto N, Nishisaka T, Fukuhara T, Taniyama K, Matsuura H, Arihiro K, Ochiai A and Yasui W: Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. Am J Surg Pathol. 32:1182–1189. 2008. View Article : Google Scholar : PubMed/NCBI

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Sentani K, Oue N, Noguchi T, Sakamoto N, Matsusaki K and Yasui W: Immunostaining of gastric cancer with neuroendocrine differentiation: Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin. Pathol Int. 60:291–297. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Oue N, Noguchi T, Anami K, Sentani K, Sakamoto N, Uraoka N, Wakamatsu Y, Sasaki H and Yasui W: Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration. Oncol Lett 2: 235-239, 2011.
APA
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N. ... Yasui, W. (2011). Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration. Oncology Letters, 2, 235-239. https://doi.org/10.3892/ol.2011.239
MLA
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N., Wakamatsu, Y., Sasaki, H., Yasui, W."Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration". Oncology Letters 2.2 (2011): 235-239.
Chicago
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N., Wakamatsu, Y., Sasaki, H., Yasui, W."Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration". Oncology Letters 2, no. 2 (2011): 235-239. https://doi.org/10.3892/ol.2011.239
Copy and paste a formatted citation
x
Spandidos Publications style
Oue N, Noguchi T, Anami K, Sentani K, Sakamoto N, Uraoka N, Wakamatsu Y, Sasaki H and Yasui W: Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration. Oncol Lett 2: 235-239, 2011.
APA
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N. ... Yasui, W. (2011). Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration. Oncology Letters, 2, 235-239. https://doi.org/10.3892/ol.2011.239
MLA
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N., Wakamatsu, Y., Sasaki, H., Yasui, W."Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration". Oncology Letters 2.2 (2011): 235-239.
Chicago
Oue, N., Noguchi, T., Anami, K., Sentani, K., Sakamoto, N., Uraoka, N., Wakamatsu, Y., Sasaki, H., Yasui, W."Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration". Oncology Letters 2, no. 2 (2011): 235-239. https://doi.org/10.3892/ol.2011.239
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