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Article

Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case

  • Authors:
    • Walid Al-Achkar
    • Abdulsamad Wafa
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission, Damascus, Syria, Jena University Hospital, Institute of Human Genetics, Jena, Germany
  • Pages: 273-276
    |
    Published online on: January 21, 2011
       https://doi.org/10.3892/ol.2011.257
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Abstract

The so-called Philadelphia (Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. Approximately 5-10% of these patients show complex translocations involving a third chromosome in addition to chromosomes 9 and 22. Since the majority of CML cases are currently treated with imatinib, variant rearrangements in general have no specific prognostic significance, although the mechanisms involved in resistance to therapy have yet to be investigated. This study evalutated a CML case with complex chromosomal aberrations not previously observed. A four chromosome translocation involving chromosomal regions such as 12q24.2-24.31 and 16p11.2 besides 9q34 and 22q11 were characterized in detail by array-proven multicolor banding (aMCB). A beneficial response to imatinib was noted in the patient.
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Copy and paste a formatted citation
Spandidos Publications style
Al-Achkar W, Wafa A and Liehr T: Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case. Oncol Lett 2: 273-276, 2011.
APA
Al-Achkar, W., Wafa, A., & Liehr, T. (2011). Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case. Oncology Letters, 2, 273-276. https://doi.org/10.3892/ol.2011.257
MLA
Al-Achkar, W., Wafa, A., Liehr, T."Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 2.2 (2011): 273-276.
Chicago
Al-Achkar, W., Wafa, A., Liehr, T."Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 2, no. 2 (2011): 273-276. https://doi.org/10.3892/ol.2011.257
Copy and paste a formatted citation
x
Spandidos Publications style
Al-Achkar W, Wafa A and Liehr T: Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case. Oncol Lett 2: 273-276, 2011.
APA
Al-Achkar, W., Wafa, A., & Liehr, T. (2011). Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case. Oncology Letters, 2, 273-276. https://doi.org/10.3892/ol.2011.257
MLA
Al-Achkar, W., Wafa, A., Liehr, T."Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 2.2 (2011): 273-276.
Chicago
Al-Achkar, W., Wafa, A., Liehr, T."Complex translocation involving four chromosomes in a novel Philadelphia-positive chronic myeloid leukemia case". Oncology Letters 2, no. 2 (2011): 273-276. https://doi.org/10.3892/ol.2011.257
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