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A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer

  • Authors:
    • Hideki Tomimoto
    • Masaki Hanibuchi
    • Fumitaka Ogushi
    • Yoshio Okano
    • Tsutomu Shinohara
    • Hiroyuki Doi
    • Akiyoshi Yamamoto
    • Eiji Takeuchi
    • Akihiko Yamamoto
    • Masahiko Azuma
    • Hiroya Tada
    • Takanori Kanematsu
    • Soji  Kakiuchi
    • Hisatsugu Goto
    • Seiji Yano
    • Yasuhiko Nishioka
    • Saburo Sone
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan, Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan, Department of Respiratory Medicine, National Hospital Organization, Kochi National Hospital, Kochi 780-8077, Japan, Department of Respiratory Medicine and Allergology, Kochi Health Sciences Center, Kochi 781-8555, Japan, Division of Respirology, Takamatsu Red Cross Hospital, Takamatsu 760-0017, Japan, Department of Internal Medicine, Kochi Red Cross Hospital, Kochi 780-8562, Japan, Division of Respirology, Matsuyama Red Cross Hospital, Matsuyama 790-8524, Japan, Department of Respiratory Medicine, National Hospital Organization, Zentsuji National Hospital, Zentsuji 765-8507, Japan
  • Pages: 465-470
    |
    Published online on: March 10, 2011
       https://doi.org/10.3892/ol.2011.266
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Abstract

S-1 is an oral anticancer fluoropyrimidine agent designed to elevate anticancer activity with a decrease in gastrointestinal toxicity. We conducted a phase II study to evaluate the efficacy and safety of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer (NSCLC). Chemotherapy-naïve patients were treated with S-1 administered orally at 40 mg/m2 twice a day for 21 consecutive days, and cisplatin (60 mg/m2) infused intravenously on day 8, repeated every 5 weeks. Of the 44 patients enrolled in the study, 40 were assessable for efficacy and safety. The median number of cycles administered was 3 (range 1-9 cycles). Among the 40 assessable patients, 7 partial responses were observed, with an overall response rate (RR) of 17.5% [95% confidence interval (CI), 5.2-29.8]. Patients with squamous cell carcinoma showed a significantly higher RR (55.5%) than those with adenocarcinoma (9.1%) or other types of NSCLC (0%). The median progression-free survival was 4.3 months (95% CI, 3.4-4.9), the median survival time was 17.9 months (95% CI, 15.0-20.8), and the 1- and 2-year survival rates were 63.3 and 27.3%, respectively. Major grade 3-4 hematologic toxicities were leukocytopenia (7.5%), neutropenia (5.0%), anemia (15.0%) and thrombocytopenia (2.5%). No grade 4 non-hematologic toxicity or treatment-related death occurred. These results suggest that combination chemotherapy with S-1 plus cisplatin is a promising therapeutic candidate for patients with advanced NSCLC, particularly squamous cell carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Tomimoto H, Hanibuchi M, Ogushi F, Okano Y, Shinohara T, Doi H, Yamamoto A, Takeuchi E, Yamamoto A, Azuma M, Azuma M, et al: A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncol Lett 2: 465-470, 2011.
APA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H. ... Sone, S. (2011). A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncology Letters, 2, 465-470. https://doi.org/10.3892/ol.2011.266
MLA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2.3 (2011): 465-470.
Chicago
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2, no. 3 (2011): 465-470. https://doi.org/10.3892/ol.2011.266
Copy and paste a formatted citation
x
Spandidos Publications style
Tomimoto H, Hanibuchi M, Ogushi F, Okano Y, Shinohara T, Doi H, Yamamoto A, Takeuchi E, Yamamoto A, Azuma M, Azuma M, et al: A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncol Lett 2: 465-470, 2011.
APA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H. ... Sone, S. (2011). A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncology Letters, 2, 465-470. https://doi.org/10.3892/ol.2011.266
MLA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2.3 (2011): 465-470.
Chicago
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2, no. 3 (2011): 465-470. https://doi.org/10.3892/ol.2011.266
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