Three-gene signature predicts disease progression of non-muscle invasive bladder cancer

  • Authors:
    • Pildu Jeong
    • Yun-Sok Ha
    • In-Chang Cho
    • Seok-Joong Yun
    • Eun Sang Yoo
    • Isaac Yi Kim
    • Yung Hyun Choi
    • Sung-Kwon Moon
    • Wun-Jae Kim
  • View Affiliations

  • Published online on: May 13, 2011     https://doi.org/10.3892/ol.2011.309
  • Pages: 679-684
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Abstract

The clinical grades and staging methods currently employed for bladder cancer (BC) are inadequate for assessing treatment outcomes for non-muscle invasive bladder cancer (NMIBC). We have developed a clinically applicable quantitative real-time PCR (qPCR) gene signature to predict the progression of NMIBC. Three genes not previously described for BC were selected from our published progression-related gene classifier data set. Data were drawn from a previous study population and from new cases. Primary NMIBC tissue specimens (n=193) were analyzed by qPCR. Risk scores were then used to rank specimens into high- and low-risk signature groups based on their gene expression. The Kaplan-Meier method and a multivariate Cox regression model were used to identify the prognostic value of the three-gene signature for both recurrence and progression. The Kaplan-Meier estimates revealed significant differences in time-to-recurrence and progression between low- and high-risk signatures (log-rank test, p=0.011 and p<0.001, respectively). The multivariate Cox regression analysis showed that the three-gene risk signature is an independent predictor of bladder tumor progression (hazard ratio, 4.268; 95% CI, 1.542-11.814; p=0.005). In conclusion, our three-gene signature was found to be closely associated with progression among patients with NMIBC.
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July-August 2011
Volume 2 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jeong P, Ha Y, Cho I, Yun S, Yoo E, Kim I, Choi Y, Moon S and Kim W: Three-gene signature predicts disease progression of non-muscle invasive bladder cancer. Oncol Lett 2: 679-684, 2011
APA
Jeong, P., Ha, Y., Cho, I., Yun, S., Yoo, E., Kim, I. ... Kim, W. (2011). Three-gene signature predicts disease progression of non-muscle invasive bladder cancer. Oncology Letters, 2, 679-684. https://doi.org/10.3892/ol.2011.309
MLA
Jeong, P., Ha, Y., Cho, I., Yun, S., Yoo, E., Kim, I., Choi, Y., Moon, S., Kim, W."Three-gene signature predicts disease progression of non-muscle invasive bladder cancer". Oncology Letters 2.4 (2011): 679-684.
Chicago
Jeong, P., Ha, Y., Cho, I., Yun, S., Yoo, E., Kim, I., Choi, Y., Moon, S., Kim, W."Three-gene signature predicts disease progression of non-muscle invasive bladder cancer". Oncology Letters 2, no. 4 (2011): 679-684. https://doi.org/10.3892/ol.2011.309