A possible predictive marker of progression for hepatocellular carcinoma

  • Authors:
    • Michele Di Stasio
    • Maria Grazia Volpe
    • Giovanni Colonna
    • Melissa Nazzaro
    • Miriam Polimeno
    • Stefania Scala
    • Giuseppe Castello
    • Susan Costantini
  • View Affiliations

  • Published online on: August 9, 2011     https://doi.org/10.3892/ol.2011.378
  • Pages: 1247-1251
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Abstract

The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down‑regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.
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November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Stasio MD, Volpe MG, Colonna G, Nazzaro M, Polimeno M, Scala S, Castello G and Costantini S: A possible predictive marker of progression for hepatocellular carcinoma. Oncol Lett 2: 1247-1251, 2011
APA
Stasio, M.D., Volpe, M.G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S. ... Costantini, S. (2011). A possible predictive marker of progression for hepatocellular carcinoma. Oncology Letters, 2, 1247-1251. https://doi.org/10.3892/ol.2011.378
MLA
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2.6 (2011): 1247-1251.
Chicago
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2, no. 6 (2011): 1247-1251. https://doi.org/10.3892/ol.2011.378