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Article

A possible predictive marker of progression for hepatocellular carcinoma

  • Authors:
    • Michele Di Stasio
    • Maria Grazia Volpe
    • Giovanni Colonna
    • Melissa Nazzaro
    • Miriam Polimeno
    • Stefania Scala
    • Giuseppe Castello
    • Susan Costantini
  • View Affiliations / Copyright

    Affiliations: Institute of Food Sciences, CNR, Avellino, Second University of Naples, Naples, Italy, Department of Biochemistry and Biophysics and Interdepartmental Research Center for Computational and Biotechnological Sciences (CRISCEB), Second University of Naples, Naples, Italy, ‘G. Pascale Foundation’ National Cancer Institute, Naples, Italy, ‘G. Pascale Foundation’ National Cancer Institute, Cancer Research Center, 83013 Mercogliano, Avellino, Italy
  • Pages: 1247-1251
    |
    Published online on: August 9, 2011
       https://doi.org/10.3892/ol.2011.378
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Abstract

The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down‑regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Stasio MD, Volpe MG, Colonna G, Nazzaro M, Polimeno M, Scala S, Castello G and Costantini S: A possible predictive marker of progression for hepatocellular carcinoma. Oncol Lett 2: 1247-1251, 2011.
APA
Stasio, M.D., Volpe, M.G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S. ... Costantini, S. (2011). A possible predictive marker of progression for hepatocellular carcinoma. Oncology Letters, 2, 1247-1251. https://doi.org/10.3892/ol.2011.378
MLA
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2.6 (2011): 1247-1251.
Chicago
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2, no. 6 (2011): 1247-1251. https://doi.org/10.3892/ol.2011.378
Copy and paste a formatted citation
x
Spandidos Publications style
Stasio MD, Volpe MG, Colonna G, Nazzaro M, Polimeno M, Scala S, Castello G and Costantini S: A possible predictive marker of progression for hepatocellular carcinoma. Oncol Lett 2: 1247-1251, 2011.
APA
Stasio, M.D., Volpe, M.G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S. ... Costantini, S. (2011). A possible predictive marker of progression for hepatocellular carcinoma. Oncology Letters, 2, 1247-1251. https://doi.org/10.3892/ol.2011.378
MLA
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2.6 (2011): 1247-1251.
Chicago
Stasio, M. D., Volpe, M. G., Colonna, G., Nazzaro, M., Polimeno, M., Scala, S., Castello, G., Costantini, S."A possible predictive marker of progression for hepatocellular carcinoma". Oncology Letters 2, no. 6 (2011): 1247-1251. https://doi.org/10.3892/ol.2011.378
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