Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-December 2011 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-December 2011 Volume 2 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

  • Authors:
    • Marta Rabello Piva
    • Lélia Batista De Souza
    • Paulo Ricardo Saquete Martins-Filho
    • Rosilene Calazans Soares
    • Thiago De Santana Santos
    • Emanuel Sávio De Souza Andrade
  • View Affiliations / Copyright

    Affiliations: Department of Oral Pathology, Federal University of Sergipe, Bairro Sanatório, CEP 49060‑100, Aracaju, Sergipe, Brazil, Department of Oral Pathology, Federal University of Rio Grande do Norte, Campus Universitário Lagoa Nova, CEP 59072-970, Natal, Rio Grande do Norte, Brazil, Department of Oral Pathology, Federal University of Sergipe, Bairro Sanatório, CEP 49060‑100, Aracaju, Sergipe, Brazil, Department of Morphology, Federal University of Sergipe, Bairro Sanatório, CEP 49060‑100, Aracaju, Sergipe, Brazil, Department of Oral and Maxillofacial Surgery, Pernambuco University, CEP 54753-220, Camaragibe, Pernambuco, Brazil, Department of Oral Pathology, Pernambuco University, CEP 54753-220, Camaragibe, Pernambuco, Brazil
  • Pages: 1225-1231
    |
    Published online on: August 16, 2011
       https://doi.org/10.3892/ol.2011.382
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to assess the suppressant role of the inflammatory infiltrate in oral carcinogenesis through the immunohistochemical expression of CD8 and FOXP3 and to discuss how representative this expression proved, as well as other parameters considered to be of prognostic value. A total of 20 cases of oral epithelial dysplasia and 40 cases of oral squamous cell carcinoma were selected. The criteria suggested by the World Health Organization were used for the histological grading of dysplasia. For carcinoma, a binary method was developed for the present study using parameters such as type of invasion, maturity, presence of epithelial masses and dysmorphism of the masses. Immunohistochemical analysis was performed for assessment of the expression of anti-CD8 and anti-FOXP3 in cases of dysplasia and carcinoma. Although the inflammatory infiltrate was more intense in the majority of carcinomas, it exercised a protective role in the dysplasia cases, as CD8 expression was significantly greater. Although a correlation was found between CD8 and the intensity of the inflammatory infiltrate in the carcinoma cases, CD8 demonstrated >5% expression in only 32.5% of the cases, compared to 80% of the dysplasia cases. Thus, we suggest that the inflammatory infiltrate should not be used as a parameter in routine examinations, as it plays different roles in the various stages of carcinogenesis. The histological grading system for malignancy employed in the present study is indicated for the assessment of oral squamous cell carcinoma.
View Figures

Figure 1

View References

1 

Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, et al: The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinoma. J Oral Pathol Med. 34:329–333. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Broders AC: Squamous-cell epithelioma of the lip: a study of five hundred and thirty-seven cases. J Am Med Assoc. 6:656–664. 1920. View Article : Google Scholar

3 

Broders AC: The microscopic grading of cancer. Surg Clin North Am. 21:947–961. 1941.

4 

Wahi PM: Tipos histológicos de tumores orales y orofaringeos. Ginebra: Organización Mundial de la Salud; 1971

5 

Jakobsson PA, Eneroth GM, Killander D, Moberger G and Artenson B: Histologic classification and grading of malignancy in carcinoma of the larynx (a pilot study). Acta Radiol Ther Phys Biol. 12:1–8. 1973. View Article : Google Scholar : PubMed/NCBI

6 

Crissman JD, Liu WY, Gluckman JL and Cummings G: Prognostic value of histopathologic parameters in squamous cell carcinoma of the oropharynx. Cancer. 54:2995–3001. 1984. View Article : Google Scholar : PubMed/NCBI

7 

Anneroth G, Batsakis JG and Luna M: Review of the literature and a recommended system of malignancy grading of squamous cell carcinoma. Scand J Dent Res. 95:222–249. 1987.PubMed/NCBI

8 

Bryne M: Is the invasive front of an oral carcinoma the most important area for prognostication? Oral diseases. 4:70–77. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Costa Ade L, Araújo RF Júnior and Ramos CC: Correlation between TNM classification and malignancy histological feature of oral squamous cell carcinoma. Braz J Otorhinolaryngol. 71:181–187. 2005.PubMed/NCBI

10 

Da Silveira EJ, Miguel MC, Lima KC, de Freitas RA, de Morais ML and Queiroz LM: Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Exp Mol Pathol. 88:171–175. 2010.PubMed/NCBI

11 

Sabel MS, Hess SD, Egilmez NK, Conway TF Jr, Chen FA and Bankert RB: CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice. Cancer Immunol Immunother. 54:944–952. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Chang MC, Chiang CP, Lin CL, Lee JJ, Hahn LJ and Jeng JH: Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 41:757–775. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Curiel TJ, Coukos G, Zou L, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts survival. Nat Med. 10:942–949. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Sato E, Olson SH, Ahn J, et al: Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA. 102:18538–18543. 2005.

15 

Fontenot JD, Gavin MA and Rudensky AY: FoxP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 4:330–336. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG and Rudensky AY: Regulatory T cell lineage specification by the forkhead transcription factor FoxP3. Immunity. 22:329–341. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Weitzman SA and Gordon LI: Inflammation and cancer: Role of phagocyte-generated oxidants in carcinogenesis. Blood. 76:655–663. 1990.PubMed/NCBI

18 

Balkwill F and Mantovani A: Inflammation and cancer: back to Virchow? The Lancet. 85:473–483. 2001.

19 

Coussens LM and Werb Z: Inflammatory cells and cancer think different! J Exp Med. 193:23–26. 2001.

20 

O’Byrne KJ and Dalgleish AG: Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer. 85:473–483. 2001.

21 

Yan L, Zucker S and Toole BP: Roles of the multifunctional glycoprotein, emmprin (basigin; CD 147), in tumour progression. Thromb Haemost. 93:199–204. 2005.PubMed/NCBI

22 

Mignona MD, Fedele S, Lo Russo L, Lo Muzio L and Bucci E: Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncol. 40:120–130. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Aggarwal BB, Shishodia S, Sandur SK, Pandey MK and Sethi G: Inflammation and cancer: How hot is the link? Biochem Pharmacol. 72:1605–1621. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Vigneswaran N, Beckers S and Waigel S: Increased EMMPRIN (CD 147) expression during oral carcinogenesis. Exp Mol Pathol. 80:147–159. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Warnakulasuriya S, Reibel J, Bouquot J and Dabelsteen E: Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med. 37:127–133. 2008. View Article : Google Scholar

26 

Abbas NF, Labib El-Sharkawy S, Abbas EA and Abdel Monem El-Shaer M: Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radio Oral Endod. 103:385–390. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Hoffmann TK, Bier H and Whiteside TL: Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neck. Cancer Immunol Immunother. 53:1055–1067. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Rabello Piva M, Batista De Souza L, Saquete Martins-Filho PR, Calazans Soares R, De Santana Santos T and Sávio De Souza Andrade E: Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system. Oncol Lett 2: 1225-1231, 2011.
APA
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P.R., Calazans Soares, R., De Santana Santos, T., & Sávio De Souza Andrade, E. (2011). Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system. Oncology Letters, 2, 1225-1231. https://doi.org/10.3892/ol.2011.382
MLA
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P. R., Calazans Soares, R., De Santana Santos, T., Sávio De Souza Andrade, E."Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system". Oncology Letters 2.6 (2011): 1225-1231.
Chicago
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P. R., Calazans Soares, R., De Santana Santos, T., Sávio De Souza Andrade, E."Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system". Oncology Letters 2, no. 6 (2011): 1225-1231. https://doi.org/10.3892/ol.2011.382
Copy and paste a formatted citation
x
Spandidos Publications style
Rabello Piva M, Batista De Souza L, Saquete Martins-Filho PR, Calazans Soares R, De Santana Santos T and Sávio De Souza Andrade E: Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system. Oncol Lett 2: 1225-1231, 2011.
APA
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P.R., Calazans Soares, R., De Santana Santos, T., & Sávio De Souza Andrade, E. (2011). Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system. Oncology Letters, 2, 1225-1231. https://doi.org/10.3892/ol.2011.382
MLA
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P. R., Calazans Soares, R., De Santana Santos, T., Sávio De Souza Andrade, E."Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system". Oncology Letters 2.6 (2011): 1225-1231.
Chicago
Rabello Piva, M., Batista De Souza, L., Saquete Martins-Filho, P. R., Calazans Soares, R., De Santana Santos, T., Sávio De Souza Andrade, E."Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system". Oncology Letters 2, no. 6 (2011): 1225-1231. https://doi.org/10.3892/ol.2011.382
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team