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Article

Estradiol induces JNK-dependent apoptosis in glioblastoma cells

  • Authors:
    • Nedret Altiok
    • Melike Ersoz
    • Meral Koyuturk
  • View Affiliations / Copyright

    Affiliations: Yeni Yuzyil University School of Medicine, Department of Pharmacology, Cevizlibag-Topkapi, Istanbul, Turkey, Institute of Medical Sciences, Istanbul Science/Bilim University, Istanbul, Turkey, Department of Histology and Embryology of Istanbul Science/Bilim University, Istanbul, Turkey
  • Pages: 1281-1285
    |
    Published online on: August 17, 2011
       https://doi.org/10.3892/ol.2011.385
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Abstract

Estrogens exert multiple regulatory actions on cellular events in a variety of tissues including the brain. In the present study, the signaling mechanisms of the concentration‑dependent effects of 17-β-estradiol (estradiol) on glioblastoma cells were investigated. Cell viability was evaluated by the trypan blue exclusion assay. Cell growth and kinase activities were evaluated by immunocytochemistry and Western blotting. The results showed that high concentrations of estradiol inhibit growth and induce apoptosis in C6 rat glioma and T98G human glioblastoma cells. The blockade of the c-jun NH2-terminal kinase (JNK) signaling pathway prevented these effects of estradiol, indicating the critical role of the JNK/c-jun signaling cascade in glioblastoma cell growth inhibition and cell death in response to high concentrations of estradiol. Collectively, these findings highlight the potential of new discoveries in sensitizing estrogen-sensitive tumors to chemotherapeutic drugs, and may lead to the development of new JNK-based effective therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Altiok N, Ersoz M and Koyuturk M: Estradiol induces JNK-dependent apoptosis in glioblastoma cells. Oncol Lett 2: 1281-1285, 2011.
APA
Altiok, N., Ersoz, M., & Koyuturk, M. (2011). Estradiol induces JNK-dependent apoptosis in glioblastoma cells. Oncology Letters, 2, 1281-1285. https://doi.org/10.3892/ol.2011.385
MLA
Altiok, N., Ersoz, M., Koyuturk, M."Estradiol induces JNK-dependent apoptosis in glioblastoma cells". Oncology Letters 2.6 (2011): 1281-1285.
Chicago
Altiok, N., Ersoz, M., Koyuturk, M."Estradiol induces JNK-dependent apoptosis in glioblastoma cells". Oncology Letters 2, no. 6 (2011): 1281-1285. https://doi.org/10.3892/ol.2011.385
Copy and paste a formatted citation
x
Spandidos Publications style
Altiok N, Ersoz M and Koyuturk M: Estradiol induces JNK-dependent apoptosis in glioblastoma cells. Oncol Lett 2: 1281-1285, 2011.
APA
Altiok, N., Ersoz, M., & Koyuturk, M. (2011). Estradiol induces JNK-dependent apoptosis in glioblastoma cells. Oncology Letters, 2, 1281-1285. https://doi.org/10.3892/ol.2011.385
MLA
Altiok, N., Ersoz, M., Koyuturk, M."Estradiol induces JNK-dependent apoptosis in glioblastoma cells". Oncology Letters 2.6 (2011): 1281-1285.
Chicago
Altiok, N., Ersoz, M., Koyuturk, M."Estradiol induces JNK-dependent apoptosis in glioblastoma cells". Oncology Letters 2, no. 6 (2011): 1281-1285. https://doi.org/10.3892/ol.2011.385
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