Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance

  • Authors:
    • Hong-Qi Liu
    • Shu Song
    • Jian-Hua Wang
    • Shao-Lan Zhang
  • View Affiliations

  • Published online on: August 31, 2011     https://doi.org/10.3892/ol.2011.399
  • Pages: 1319-1322
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the expression of matrix metalloproteinase-3 (MMP-3) and the tissue inhibitor of metalloproteinase-3 (TIMP-3) in gastric cancer tissue, as well as to analyze the correlation between their expression and the occurrence of gastric cancer. Immunohistochemistry was used to determine the expression of MMP-3 and TIMP-3 in the gastric cancer tissue from 18 patients with early-stage gastric cancer (early‑stage group) and 26 patients with advanced-stage gastric cancer (advanced‑stage group). Transmission electron microscopy (TEM) was used to observe the lymphocytes and tumor cells in gastric cancer tissue. The results showed that the expression of TIMP-3 was significantly higher, whereas that of MMP-3 and MMP-3/TIMP-3 was lower in gastric cancer tissue of the early‑stage group than in that of the advanced‑stage group (P<0.05). The TEM images revealed increased lymphocytes and inconspicuous tumor cells penetrating the basement membrane in gastric cancer tissue of the early-stage group, and decreased lymphocytes and obvious tumor cells penetrating the basement membrane in the advanced‑stage group. In conclusion, MMP-3 and TIMP-3 may be used as indices for the invasion and metastasis of gastric cancer and possess marked clinical significance in the prognostic judgment of gastric cancer.
View Figures
View References

Related Articles

Journal Cover

November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Song S, Wang J and Zhang S: Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncol Lett 2: 1319-1322, 2011
APA
Liu, H., Song, S., Wang, J., & Zhang, S. (2011). Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncology Letters, 2, 1319-1322. https://doi.org/10.3892/ol.2011.399
MLA
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2.6 (2011): 1319-1322.
Chicago
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2, no. 6 (2011): 1319-1322. https://doi.org/10.3892/ol.2011.399