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Article

Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance

  • Authors:
    • Hong-Qi Liu
    • Shu Song
    • Jian-Hua Wang
    • Shao-Lan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Yancheng First People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Pathology, Yancheng First People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Gastroenterology, Yancheng First People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Medical Technology, Yancheng Health Vocational and Technical College, Yancheng 224006, P.R. China
  • Pages: 1319-1322
    |
    Published online on: August 31, 2011
       https://doi.org/10.3892/ol.2011.399
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Abstract

The present study aimed to investigate the expression of matrix metalloproteinase-3 (MMP-3) and the tissue inhibitor of metalloproteinase-3 (TIMP-3) in gastric cancer tissue, as well as to analyze the correlation between their expression and the occurrence of gastric cancer. Immunohistochemistry was used to determine the expression of MMP-3 and TIMP-3 in the gastric cancer tissue from 18 patients with early-stage gastric cancer (early‑stage group) and 26 patients with advanced-stage gastric cancer (advanced‑stage group). Transmission electron microscopy (TEM) was used to observe the lymphocytes and tumor cells in gastric cancer tissue. The results showed that the expression of TIMP-3 was significantly higher, whereas that of MMP-3 and MMP-3/TIMP-3 was lower in gastric cancer tissue of the early‑stage group than in that of the advanced‑stage group (P<0.05). The TEM images revealed increased lymphocytes and inconspicuous tumor cells penetrating the basement membrane in gastric cancer tissue of the early-stage group, and decreased lymphocytes and obvious tumor cells penetrating the basement membrane in the advanced‑stage group. In conclusion, MMP-3 and TIMP-3 may be used as indices for the invasion and metastasis of gastric cancer and possess marked clinical significance in the prognostic judgment of gastric cancer.
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1 

Bi J, Lau SH, Hu L, et al: Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer. Int J Cancer. 124:1587–1593. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Zheng L, Pu J, Jiang G, Weng M, He J, Mei H, Hou X and Tong Q: Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription. Pathol Int. 60:268–277. 2010. View Article : Google Scholar

3 

Stetler-Stevenson WG: The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis. Surg Oncol Clin N Am. 10:383–392. 2001.PubMed/NCBI

4 

Lawson JD, Sicklick JK and Fanta PT: Gastric cancer. Curr Probl Cancer. 35:97–127. 2011. View Article : Google Scholar

5 

Watanabe H: Extracellular matrix – regulation of cancer invasion and metastasis [J]. Gan To Kagaku Ryoho. 37:2058–2061. 2010.

6 

Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 278:16–27. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Jin X, Yagi M, Akiyama N, Hirosaki T, Higashi S, Lin CY, Dickson RB, Kitamura H and Miyazaki K: Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis. Cancer Sci. 97:1327–1334. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Zinzindohoué F, Lecomte T, Ferraz JM, Houllier AM, Cugnenc PH, Berger A, Blons H and Laurent-Puig P: Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer. Clin Cancer Res. 11:594–599. 2005.PubMed/NCBI

9 

Fiedorczyk M, Klimiuk PA, Sierakowski S, Domyslawska l and Chwiecko J: Correlations between serum matrix metalloproteinase (MMP-1, MMP-3, MMP-9, MMP-13) concentrations and markers of disease activity in early rheumatoid arthritis. Przegl Lek. 62:1321–1324. 2005.

10 

Pietruszewska W, Kobos J, Gryczyński M, Durko T and Bojanowska-Pożniak K: Analysis of TIMP-1, TIMP-2 and TIMP-3 expression as a prognostic factor of laryngeal cancer progression. Otolaryngol Pol. 62:380–387. 2008.PubMed/NCBI

11 

Lee MH, Atkinson S and Murphy G: Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1. J Biol Chem. 282:6887–6898. 2007.PubMed/NCBI

12 

Li YH, Shao JY, Li S, Zou BY, Huang HQ and Guan ZZ: Clinical significance of quantitative analysis of serum VEGF, CD44s, and MMP-3 protein in nasopharyngeal carcinoma. Ai Zheng. 23:1060–1064. 2004.PubMed/NCBI

13 

Argüello-Ramírez J, Pérez-Cárdenas E, Delgado-Chávez R, Solorza-Luna G, Villa-Trevińo S and Arenas-Huertero F: Matrix metalloproteinases-2, -3, and -9 secreted by explants of benign and malignant lesions of the uterine cervix. Int J Gynecol Cancer. 14:330–340. 2004.PubMed/NCBI

14 

Mylona E, Magkou C, Giannopoulou I, Agrogiannis G, Markaki S, Keramopoulos A and Nakopoulou L: Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: relation to tumor phenotype and clinical outcome. Breast Cancer Res. 8:R572006. View Article : Google Scholar : PubMed/NCBI

15 

Mino N, Takenaka K, Sonobe M, Miyahara R, Yanagihara K, Otake Y, Wada H and Tanaka F: Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer. J Surg Oncol. 95:250–257. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Işlekel H, Oktay G, Terzi C, Canda AE, Fűzűn M and Kűpelioğlu A: Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer: relationship to clinicopathological variables. Cell Biochem Funct. 25:433–441. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Song S, Wang J and Zhang S: Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncol Lett 2: 1319-1322, 2011.
APA
Liu, H., Song, S., Wang, J., & Zhang, S. (2011). Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncology Letters, 2, 1319-1322. https://doi.org/10.3892/ol.2011.399
MLA
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2.6 (2011): 1319-1322.
Chicago
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2, no. 6 (2011): 1319-1322. https://doi.org/10.3892/ol.2011.399
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Song S, Wang J and Zhang S: Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncol Lett 2: 1319-1322, 2011.
APA
Liu, H., Song, S., Wang, J., & Zhang, S. (2011). Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance. Oncology Letters, 2, 1319-1322. https://doi.org/10.3892/ol.2011.399
MLA
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2.6 (2011): 1319-1322.
Chicago
Liu, H., Song, S., Wang, J., Zhang, S."Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical significance". Oncology Letters 2, no. 6 (2011): 1319-1322. https://doi.org/10.3892/ol.2011.399
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