Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas

  • Authors:
    • Hiroya Iida
    • Masaki Hata
    • Ayako Kakuno
    • Hiroshi Hirano
    • Koji Yamanegi
    • Naoko Yamada
    • Hideki Ohyama
    • Nobuyuki Terada
    • Chiaki Yasui
    • Naoki Yamanaka
    • Keiji Nakasho
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  • Published online on: September 2, 2011     https://doi.org/10.3892/ol.2011.405
  • Pages: 1041-1046
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Abstract

In this study, the expression of hepatocyte markers, including α-fetoprotein (AFP), HepPar-1 antigen and arginase-1, was examined immunohistochemically in 14 mass-forming peripheral intrahepatic cholangiocarcinomas (ICCs) that arose from the peripheral portion of the biliary tree, and in 14 periductal-infiltrating hilar ICCs that arose from intrahepatic large bile ducts. Only 2 (14.3%) of the 14 hilar ICCs and 2 (14.3%) of the 14 peripheral ICCs expressed AFP or HepPar-1 antigen. Conversely, arginase-1 was expressed in 8 (57.1%) and 11 (78.6%) of the hilar and peripheral ICCs, respectively, and 4 (28.6%) hilar ICCs and 7 (50%) peripheral ICCs expressed arginase-1 in more than 10% of the cancer cells. The expression of arginase-1 did not differ between peripheral ICCs showing major histology of poorly differentiated adenocarcinoma and those showing other major histologies, including well- or moderately differentiated tubular adenocarcinoma or papillary adenocarcinoma. Results of the present study showed that common hepatocyte markers, including AFP and HepPar-1 antigen, are rarely but definitely expressed in hilar and peripheral ICCs, and that a third hepatocyte marker, arginase-1, is expressed at a high rate in both hilar and peripheral ICCs, irrespective of their histology. These results indicate that care should be taken when using arginase-1 as a hepatocyte marker for distinguishing between a poorly differentiated hepatocellular carcinoma and a mass‑forming peripheral ICC showing the histology of poorly differentiated adenocarcinoma.
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November-December 2011
Volume 2 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Iida H, Hata M, Kakuno A, Hirano H, Yamanegi K, Yamada N, Ohyama H, Terada N, Yasui C, Yamanaka N, Yamanaka N, et al: Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. Oncol Lett 2: 1041-1046, 2011
APA
Iida, H., Hata, M., Kakuno, A., Hirano, H., Yamanegi, K., Yamada, N. ... Nakasho, K. (2011). Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas. Oncology Letters, 2, 1041-1046. https://doi.org/10.3892/ol.2011.405
MLA
Iida, H., Hata, M., Kakuno, A., Hirano, H., Yamanegi, K., Yamada, N., Ohyama, H., Terada, N., Yasui, C., Yamanaka, N., Nakasho, K."Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas". Oncology Letters 2.6 (2011): 1041-1046.
Chicago
Iida, H., Hata, M., Kakuno, A., Hirano, H., Yamanegi, K., Yamada, N., Ohyama, H., Terada, N., Yasui, C., Yamanaka, N., Nakasho, K."Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas". Oncology Letters 2, no. 6 (2011): 1041-1046. https://doi.org/10.3892/ol.2011.405