Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas

Iida,Hiroya; Hata,Masaki; Kakuno,Ayako; Hirano,Hiroshi; Yamanegi,Koji; Yamada,Naoko; Ohyama,Hideki; Terada,Nobuyuki; Yasui,Chiaki; Yamanaka,Naoki; Nakasho,Keiji

doi:10.3892/ol.2011.405

November-December 2011 Volume 2 Issue 6

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November-December 2011 Volume 2 Issue 6

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Article

Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas

Authors:
- Hiroya Iida
- Masaki Hata
- Ayako Kakuno
- Hiroshi Hirano
- Koji Yamanegi
- Naoko Yamada
- Hideki Ohyama
- Nobuyuki Terada
- Chiaki Yasui
- Naoki Yamanaka
- Keiji Nakasho
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Affiliations: Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Department of Pathology, Meiwa General Hospital, Nishinomiya, Hyogo 663-8186, Japan, Department of Pathology, Nippon Steel Hirohata Hospital, Himeji, Hyogo 671-1122, Japan, Department of Surgery, Meiwa General Hospital, Nishinomiya, Hyogo 663-8186, Japan
Pages: 1041-1046
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Published online on: September 2, 2011

https://doi.org/10.3892/ol.2011.405
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Abstract

In this study, the expression of hepatocyte markers, including α-fetoprotein (AFP), HepPar-1 antigen and arginase-1, was examined immunohistochemically in 14 mass-forming peripheral intrahepatic cholangiocarcinomas (ICCs) that arose from the peripheral portion of the biliary tree, and in 14 periductal-infiltrating hilar ICCs that arose from intrahepatic large bile ducts. Only 2 (14.3%) of the 14 hilar ICCs and 2 (14.3%) of the 14 peripheral ICCs expressed AFP or HepPar-1 antigen. Conversely, arginase-1 was expressed in 8 (57.1%) and 11 (78.6%) of the hilar and peripheral ICCs, respectively, and 4 (28.6%) hilar ICCs and 7 (50%) peripheral ICCs expressed arginase-1 in more than 10% of the cancer cells. The expression of arginase-1 did not differ between peripheral ICCs showing major histology of poorly differentiated adenocarcinoma and those showing other major histologies, including well- or moderately differentiated tubular adenocarcinoma or papillary adenocarcinoma. Results of the present study showed that common hepatocyte markers, including AFP and HepPar-1 antigen, are rarely but definitely expressed in hilar and peripheral ICCs, and that a third hepatocyte marker, arginase-1, is expressed at a high rate in both hilar and peripheral ICCs, irrespective of their histology. These results indicate that care should be taken when using arginase-1 as a hepatocyte marker for distinguishing between a poorly differentiated hepatocellular carcinoma and a mass‑forming peripheral ICC showing the histology of poorly differentiated adenocarcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas

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