Effects of S-1 as a second-line chemotherapy for patients with relapsed pancreatic cancer

Ishido,Keinosuke; Toyoki,Yoshikazu; Kudo,Daisuke; Kimura,Norihisa; Yamana,Daisuke; Miura,Takuya; Tsutsumi,Shinji; Muroya,Takahiro; Yoshikawa,Toru; Ogasawara,Hiroshi; Yonaiyama,Shinnosuke; Narumi,Shunji; Hakamada,Kenichi

doi:10.3892/ol.2011.412

November-December 2011 Volume 2 Issue 6

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November-December 2011 Volume 2 Issue 6

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Article

Effects of S-1 as a second-line chemotherapy for patients with relapsed pancreatic cancer

Authors:
- Keinosuke Ishido
- Yoshikazu Toyoki
- Daisuke Kudo
- Norihisa Kimura
- Daisuke Yamana
- Takuya Miura
- Shinji Tsutsumi
- Takahiro Muroya
- Toru Yoshikawa
- Hiroshi Ogasawara
- Shinnosuke Yonaiyama
- Shunji Narumi
- Kenichi Hakamada
View Affiliations / Copyright

Affiliations: Department of Gastrointestinal Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Pages: 1313-1317
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Published online on: September 5, 2011

https://doi.org/10.3892/ol.2011.412
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Abstract

Adjuvant chemotherapy with gemcitabine is the standard treatment in Japan for patients who have undergone resection of pancreatic cancer. However, few reports have described suitable regimens for patients who present cancer relapse following adjuvant chemotherapy. In the present study, we retrospectively evaluated the efficacy and safety of S-1, an oral fluoropyrimidine derivative, as a second-line chemotherapy for patients who had suffered relapse of pancreatic cancer following adjuvant chemotherapy with gemcitabine. A total of 51 patients with pancreatic cancer suffered relapse after curative resection and subsequent adjuvant chemotherapy with gemcitabine at our institution. A group of 26 of these patients were administered S-1 orally twice daily after meals at a dose of 80 mg/m2 for body surface areas for 14 consecutive days, followed by a 7-day rest (S-1 group). The remaining 25 patients received no additional anticancer drugs other than continuation of gemcitabine (GEM/BSC group). During a median follow-up period of 35 months, a significant difference was observed in overall survival (OAS) between the S-1 group and the control group (median OAS, 20.9 vs. 13.7 months; p=0.0157, log-rank test). Furthermore, there was a significant inter-group difference in survival after relapse (SAR) (median SAR, 11.4 vs. 6.20 months; p=0.0025, log-rank test). No increase in grade 3/4 hematological and non-hematological toxicity was observed in the S-1 group. In conclusion, second-line chemotherapy using a combination of S-1 and adjuvant chemotherapy with gemcitabine may be an efficient and beneficial strategy for patients with relapsed pancreatic cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of S-1 as a second-line chemotherapy for patients with relapsed pancreatic cancer

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