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Article

Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity

  • Authors:
    • Debasish Bandyopadhyay
    • Jose C. Granados
    • John D. Short
    • Bimal K. Banik
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, The University of Texas-Pan American, Edinburg, Texas 78539, USA, University of Texas Health Science Center at San Antonio-Regional Academic Health Center, Medical Research Division, Edinburg, TX 78541, USA
  • Pages: 45-49
    |
    Published online on: October 4, 2011
       https://doi.org/10.3892/ol.2011.436
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Abstract

Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.
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Copy and paste a formatted citation
Spandidos Publications style
Bandyopadhyay D, Granados JC, Short JD and Banik BK: Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity. Oncol Lett 3: 45-49, 2012.
APA
Bandyopadhyay, D., Granados, J.C., Short, J.D., & Banik, B.K. (2012). Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity. Oncology Letters, 3, 45-49. https://doi.org/10.3892/ol.2011.436
MLA
Bandyopadhyay, D., Granados, J. C., Short, J. D., Banik, B. K."Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity". Oncology Letters 3.1 (2012): 45-49.
Chicago
Bandyopadhyay, D., Granados, J. C., Short, J. D., Banik, B. K."Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity". Oncology Letters 3, no. 1 (2012): 45-49. https://doi.org/10.3892/ol.2011.436
Copy and paste a formatted citation
x
Spandidos Publications style
Bandyopadhyay D, Granados JC, Short JD and Banik BK: Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity. Oncol Lett 3: 45-49, 2012.
APA
Bandyopadhyay, D., Granados, J.C., Short, J.D., & Banik, B.K. (2012). Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity. Oncology Letters, 3, 45-49. https://doi.org/10.3892/ol.2011.436
MLA
Bandyopadhyay, D., Granados, J. C., Short, J. D., Banik, B. K."Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity". Oncology Letters 3.1 (2012): 45-49.
Chicago
Bandyopadhyay, D., Granados, J. C., Short, J. D., Banik, B. K."Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity". Oncology Letters 3, no. 1 (2012): 45-49. https://doi.org/10.3892/ol.2011.436
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