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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January 2012 Volume 3 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer

  • Authors:
    • Gui-Ping Yu
    • Yong Ji
    • Guo-Qiang Chen
    • Bin Huang
    • Kai Shen
    • Song Wu
    • Zhen-Ya Shen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Affiliated Jangyin People's Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, P.R. China
  • Pages: 159-162
    |
    Published online on: October 19, 2011
       https://doi.org/10.3892/ol.2011.450
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Abstract

The purpose of this study was to detect the methy-lation of the RUNX3 gene promoter in non-small cell lung cancer (NSCLC) tissue and to explore the association of this methylation with clinical features of NSCLC. In 58 samples of NSCLC tissue and normal adjacent tissue, methylation of the RUNX3 gene promoter was measured by methylation-specific polymerase chain reaction. Correlation with clinicopathological characteristics was assessed. The results demonstrated that RUNX3 gene promoter methylation was present in 26/58 (44.8%) of NSCLC tissue samples and 10/58 (17.2%) of normal tissue samples, and that the difference was statistically significant between the two groups (χ2=10.311, p=0.001). Significantly, methylation of the RUNX3 gene promoter correlated with clinical stage, lymph node metastasis and the degree of differentiation (p<0.05) but not with age, gender, smoking history and pathological type (p>0.05). In conclusion, methylation of the RUNX3 gene promoter had a high relevance ratio in NSCLC tissue and correlated with clinical stage, lymph node metastasis and degree of differentiation; thus, this association may have clinical significance in NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu G, Ji Y, Chen G, Huang B, Shen K, Wu S and Shen Z: Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncol Lett 3: 159-162, 2012.
APA
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., & Shen, Z. (2012). Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncology Letters, 3, 159-162. https://doi.org/10.3892/ol.2011.450
MLA
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., Shen, Z."Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer". Oncology Letters 3.1 (2012): 159-162.
Chicago
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., Shen, Z."Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer". Oncology Letters 3, no. 1 (2012): 159-162. https://doi.org/10.3892/ol.2011.450
Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Ji Y, Chen G, Huang B, Shen K, Wu S and Shen Z: Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncol Lett 3: 159-162, 2012.
APA
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., & Shen, Z. (2012). Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer. Oncology Letters, 3, 159-162. https://doi.org/10.3892/ol.2011.450
MLA
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., Shen, Z."Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer". Oncology Letters 3.1 (2012): 159-162.
Chicago
Yu, G., Ji, Y., Chen, G., Huang, B., Shen, K., Wu, S., Shen, Z."Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer". Oncology Letters 3, no. 1 (2012): 159-162. https://doi.org/10.3892/ol.2011.450
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