Expression of c-Kit and PDGFRα in epithelial ovarian tumors and tumor stroma

  • Authors:
    • Cunjian Yi
    • Li Li
    • Keming Chen
    • Shengrong Lin
    • Xiangqiong Liu
  • View Affiliations

  • Published online on: November 15, 2011     https://doi.org/10.3892/ol.2011.481
  • Pages: 369-372
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Abstract

The purpose of this study was to investigate the expression of c-Kit and platelet-derived growth factor receptor α (PDGFRα) in epithelial ovarian tumor cells and tumor stroma. The expression of c-Kit and PDGFRα in 71 malignant or benign epithelial ovarian tumor tissues and 20 normal ovarian tissues was evaluated by immunohistochemical staining. The expression of c-Kit and PDGFRα in 71 malignant epithelial ovarian tumors and tumor stroma tissue samples was analyzed. A significant increase (P<0.01) of c-Kit expression was observed in malignant ovarian tumors (50.7%) when compared to normal ovarian tissues (10.0%) or benign ovarian tumors (20.0%). The PDGFRα expression rate in malignant ovarian tumors (63.4%) was also significantly higher (P<0.01) than that in normal ovarian tissues (15.0%) or benign ovarian tumors (25.0%). c-Kit was expressed in only 4.2% of the tumor stroma samples, which was significantly lower than the expression of malignant ovarian tumors (P<0.01), whereas the PDGFRα expression in tumor stroma (87.3%) was significantly higher than that of the malignant ovarian tumors (P<0.01). The expression levels of c-Kit and PDGFRα are higher in the malignant ovarian tumors than in the benign ovarian tumors or normal tissues. In the malignant ovarian tumor stroma, c-Kit expression is low and PDGFRα expression is high, and the differential changes of c-kit and PDGFRα suggest distinct roles in ovarian cancer.
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February 2012
Volume 3 Issue 2

Print ISSN: 1792-1074
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Spandidos Publications style
Yi C, Li L, Chen K, Lin S and Liu X: Expression of c-Kit and PDGFRα in epithelial ovarian tumors and tumor stroma. Oncol Lett 3: 369-372, 2012.
APA
Yi, C., Li, L., Chen, K., Lin, S., & Liu, X. (2012). Expression of c-Kit and PDGFRα in epithelial ovarian tumors and tumor stroma. Oncology Letters, 3, 369-372. https://doi.org/10.3892/ol.2011.481
MLA
Yi, C., Li, L., Chen, K., Lin, S., Liu, X."Expression of c-Kit and PDGFRα in epithelial ovarian tumors and tumor stroma". Oncology Letters 3.2 (2012): 369-372.
Chicago
Yi, C., Li, L., Chen, K., Lin, S., Liu, X."Expression of c-Kit and PDGFRα in epithelial ovarian tumors and tumor stroma". Oncology Letters 3, no. 2 (2012): 369-372. https://doi.org/10.3892/ol.2011.481