Nucleolar organizer regions in a chronic stress and oral cancer model

Muñoz Ruz,Ivonne   Andrea; Droguett Ossa,Daniel   Andrés; Donoso Torres,Wendy   Karina; Kemmerling,Ulrike; Venegas Rojas,Bernardo   Arturo; Rivera Martínez,César   Andrés

doi:10.3892/ol.2011.514

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

Nucleolar organizer regions in a chronic stress and oral cancer model

Authors:
- Ivonne Andrea Muñoz Ruz
- Daniel Andrés Droguett Ossa
- Wendy Karina Donoso Torres
- Ulrike Kemmerling
- Bernardo Arturo Venegas Rojas
- César Andrés Rivera Martínez
View Affiliations / Copyright

Affiliations: Department of Stomatology, Faculty of Health Sciences, University of Talca, Talca, Chile, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca, Chile
Pages: 541-544
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Published online on: December 6, 2011

https://doi.org/10.3892/ol.2011.514
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Abstract

This study aimed to examine the role of chronic restraint stress (RS) on oral squamous cell carcinomas induced by 4-nitroquinoline-1-oxide (4-NQO) in CF-1 mouse tongues, measured by the expression of argyrophilic staining of nucleolar organizer regions (AgNOR). Thirty one samples of lingual epithelial tissue of CF-1 mice with a diagnosis of oral squamous cell carcinoma (OSSC) were assigned to two experimental groups: the RS/4-NQO group, where animals received RS and induction of oral chemical carcinogenesis (n=17); and the 4-NQO group, where animals received induction of chemical carcinogenesis without restraint stress (n=14). The mean number and distribution pattern of AgNOR were recorded. The mean AgNOR number per cell was found to be slightly higher in the 4-NQO group. AgNOR in the RS/4-NQO group revealed a higher tendency to be arranged in a clumped distribution compared to the 4-NQO group. No statistically significant difference was found between the groups. In conclusion, the induction of chronic restraint stress in CF-1 mice does not increase the number or affect the distribution pattern of AgNORs in OSSC induced by 4-NQO.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Nucleolar organizer regions in a chronic stress and oral cancer model

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