Histopathological study of colo-ileal carcinoma

Matsukuma,Susumu; Okada,Kenji; Takeo,Hiroaki; Sato,Kimiya

doi:10.3892/ol.2011.538

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

Histopathological study of colo-ileal carcinoma

Authors:
- Susumu Matsukuma
- Kenji Okada
- Hiroaki Takeo
- Kimiya Sato
View Affiliations / Copyright

Affiliations: Department of Pathology, Japan Self Defense Forces Central Hospital, Setagaya-ku, Tokyo 154-0001, Japan
Pages: 689-693
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Published online on: December 23, 2011

https://doi.org/10.3892/ol.2011.538
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Abstract

Cases of colo-ileal carcinoma (CIC), defined as intestinal carcinoma involving the right-sided colon and the ileum, are rarely encountered. The aim of this study was to elucidate the clinicopathological characteristics, which have been poorly understood, in such cases. A total of 16 CICs were examined histologically and immunohistochemically. Microsatellite instability-related histology was also evaluated according to previously published models, such as MsPath and PREDICT. CICs included 14 adenocarcinomas and 2 mucinous adenocarcinomas. The CICs showed focal or diffuse cytokeratin 20 expression and 7 CICs showed focal cytokeratin 7 co-expression. MsPath and PREDICT scores ranged from 1.6 to 6.6 (mean, 3.14) and from 1.6 to 7.8 (mean, 3.86), respectively. Three CICs showed loss of MLH1 immunoreactivity. Prominent neutrophilia and cancerous lymphangiosis in Peyer's patches (CLPP) were found in 8 cases (50%) and in 3 cases (18.8%), respectively. Neither variable was associated with parameters such as gender, tumor size or poor prognosis. However, the PREDICT score in prominently neutrophilic CICs was significantly higher than that in CICs with non-prominent neutrophilia (P=0.004). Patients with CLPP-positive CICs were significantly younger than those with CLPP-negative CICs (P=0.031). This study showed that almost all CICs originate from the right-sided colon with possible high levels of microsatellite instability. Prominent neutrophilia may be an additional histological indicator for microsatellite instability. Prognosis-independent CLPP occasionally occurs in younger patients with CICs.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histopathological study of colo-ileal carcinoma

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