Efficient association analysis between colorectal cancer and allelic polymorphisms of HLA‑DQB1 by comparison of age of onset

Tong,Fengzhi; Yu,Weijian; Liu,Hui

doi:10.3892/ol.2011.540

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Efficient association analysis between colorectal cancer and allelic polymorphisms of HLA‑DQB1 by comparison of age of onset

Authors:
- Fengzhi Tong
- Weijian Yu
- Hui Liu
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Affiliations: Dalian Fifth Hospital, Dalian Medical University, Dalian 116044, P.R. China, Dalian Blood Center, Dalian Medical University, Dalian 116044, P.R. China, Department of Clinical Immunology, Dalian Medical University, Dalian 116044, P.R. China
Pages: 517-519
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Published online on: December 28, 2011

https://doi.org/10.3892/ol.2011.540
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Abstract

Common methods for identifying cancer‑related genes are solely based on differences between gene frequencies in the disease and control groups, and do not take into account the age of onset in the gene carriers. In the present investigation, we developed a new study design based on the age of onset of cancer for the identification of colorectal cancer-related genes. The samples from patients with colorectal cancer were typed using an HLA-DQB1 polymerase chain reaction using a sequence-specific primers (PCR-SSP) typing kit. The mean age of subjects with and without the alleles was calculated. The mean age of subjects with the HLA-DQB1*02 allele was significantly less than that of subjects without this allele (p<0.05). We found that the HLA-DQB1*02 allele was associated with colorectal cancer susceptibility. This new method of analysis may therefore be an efficient and reliable approach for the identification of cancer-causing genes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficient association analysis between colorectal cancer and allelic polymorphisms of HLA‑DQB1 by comparison of age of onset

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