Comparison of distribution characteristics of metastatic bone lesions between breast and prostate carcinomas

Wang,Chang-Yin; Wu,Guang-Yao; Shen,Mei-Juan; Cui,Kun-Wei; Shen,Ying

doi:10.3892/ol.2012.1005

January 2013 Volume 5 Issue 1

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January 2013 Volume 5 Issue 1

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Article

Comparison of distribution characteristics of metastatic bone lesions between breast and prostate carcinomas

Authors:
- Chang-Yin Wang
- Guang-Yao Wu
- Mei-Juan Shen
- Kun-Wei Cui
- Ying Shen
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Affiliations: Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China, Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P.R. China
Pages: 391-397
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Published online on: October 30, 2012

https://doi.org/10.3892/ol.2012.1005
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Abstract

The purpose of the present study was to investigate the distribution characteristics of bone metastases in breast and prostate carcinomas. Bone scintigraphies were performed in 504 cancer patients. We studied the correlation between the distribution and total number of metastatic bone lesions, and compared the distribution of metastatic bone lesions between breast and prostate carcinomas. In the early stage, the distribution in the thoracic vertebrae, lumbar vertebrae and pelvis of the metastatic lesions of the prostate carcinoma (81.0%, 47/58) was significantly higher than that of the breast carcinoma (41.7%, 63/151; χ2=27.6, P=0.000). The distribution of the lesions in the thoracic skeleton in the cases of the breast carcinoma (65.6%, 99/151) was significantly higher than that of the prostate carcinoma (27.6%, 16/58; χ2=24.8, P=0.000); however, the distributions in the advanced cases were not markedly different. The differences in the proportions of the metastatic lesions in the lumbar vertebrae (χ2=56.1, P=0.000) and ribs (χ2=39.1, P=0.000) in the cases of the prostate carcinoma, and in the sternum (χ2=31.2, P=0.000), skull (χ2=26.5, P=0.000) and femur (χ2=13.6, P=0.001) in the cases of the breast carcinoma were significant. Between the breast and prostate carcinomas, the differences in the proportions of the metastatic lesions of certain bones were also significant. In cases with few bone metastases, the proportion of sternum metastases of patients with breast carcinoma (17.9%) was significantly higher than that of patients with prostate carcinoma (1.7%; χ2=12.7, P=0.000); the proportion of metastases in the lumbar vertebrae of prostate carcinoma (39.7%) was significantly higher than that of breast carcinoma (13.9%; χ2=15.4, P=0.000); the proportion of rib metastases of breast carcinoma (27.2%) was significantly higher than that of prostate carcinoma (8.6%; χ2=9.6, P=0.002). In cases with extensive bone metastases, the proportions of metastatic lesions in the sternum and lumbar vertebrae in breast and prostate carcinomas were not significantly different (P>0.05). In conclusion, the distribution of bone metastases is correlated with the total number of metastatic bone lesions in breast and prostate carcinoma patients, and has different characteristics in different lesions.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparison of distribution characteristics of metastatic bone lesions between breast and prostate carcinomas

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