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Case Report

Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature

  • Authors:
    • Shinsuke Funakoshi
    • Akinori Hashiguchi
    • Kana Teramoto
    • Naoteru Miyata
    • Satoshi Kurita
    • Masayuki Adachi
    • Yasuo Hamamoto
    • Hajime  Higuchi
    • Hiromasa Takaishi
    • Toshifumi Hibi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Division of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan, Department of Pathology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan
  • Pages: 117-122
    |
    Published online on: October 30, 2012
       https://doi.org/10.3892/ol.2012.1008
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Abstract

Small cell esophageal carcinoma is a type of small cell neuroendocrine carcinoma (SCNEC). SCNEC follows an aggressive clinical course and has a poor prognosis despite multidisciplinary therapies. A standard therapeutic strategy, including surgery, radiation and first-/second‑line chemotherapy, has not yet been established for SCNEC. We present a case of SCNEC of the esophagus. A 66-year-old male with SCNEC as extensive disease was treated with 60 mg/m2 cisplatin on day 1 plus 60 mg/m2 irinotecan on days 1, 8 and 15 every 4 weeks (IP) with successful complete remission. After the sixth course of IP, increasing pro-gastrin-releasing peptide (ProGRP) and nonspecific enolase (NSE) levels and intense fluorodeoxyglucose (FDG) avidity in a lymph node around the celiac artery (SUVmax, 8.3) indicated a refractory relapse of the disease. The patient was treated with three courses of amrubicin (AMR, 35 mg/m2) administered intravenously for 3 consecutive days every 3 weeks as a second‑line chemotherapy. The ProGRP and NSE levels returned to the normal range 1 month after the initiation of second-line chemotherapy. However, the ProGRP and NSE levels were elevated after the third course of AMR, and PET-CT revealed progressive disease with liver metastasis and extended lymph node metastasis. As the patient remained asymptomatic, paclitaxel (100 mg/m2) was started as third-line chemotherapy. Patients with SCNEC of the esophagus with extensive disease should be treated with aggressive chemotherapy rather than surgery or radiation monotherapy. In the present case, tumor markers such as ProGRP and NSE were predictive of relapse and PET-CT was used to detect relapse. Further research is required to identify and exploit promising agents for resistant SCNEC.
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1 

McKeown F: Oat-cell carcinoma of the oesophagus. J Pathol Bacteriol. 64:889–891. 1952. View Article : Google Scholar : PubMed/NCBI

2 

Brenner B, Tang LH, Klimstra DS and Kelsen DP: Small-cell carcinomas of the gastrointestinal tract: a review. J Clin Oncol. 22:2730–2739. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lv J, Liang J, Wang J, et al: Primary small cell carcinoma of the esophagus. J Thorac Oncol. 3:1460–1465. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Klöppel G, Rindi G, Perren A, Komminoth P and Klimstra DS: The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Arch. 456:595–597. 2010.PubMed/NCBI

5 

Williams E and Sandler M: The classification of carcinoid tumours. Lancet. 7275:238–239. 1963. View Article : Google Scholar : PubMed/NCBI

6 

Solcia E, Klöppel G and Sobin LH: Histological Typing of Endocrine Tumours. World Health Organization - International Histological Classification of Tumours. 2nd edition. Springer; Berlin, Germany: 2000, View Article : Google Scholar

7 

Klöppel G: Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer. 18(Suppl 1): S1–S16. 2011.

8 

Rice TW: Staging of esophageal cancer: TNM and beyond. Esophagus. 7:189–195. 2010. View Article : Google Scholar

9 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumors. 7th edition. Wiley-Blackwell; Oxford, UK: 2009

10 

Stahel RA, Ginsberg R, Havemann K, et al: Staging and prognostic factors in small cell lung cancer; a consensus report. Lung Cancer. 5:119–126. 1989. View Article : Google Scholar

11 

Rindi G and Wiedenmann B: Neuroendocrine neoplasms of the gut and pancreas: new insights. Nat Rev Endocrinol. 8:54–64. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Howard S, O’Regan K, Jagannathan J, Krajewski K, Giardino A and Ramaiya N: Extrapulmonary small cell carcinoma: a pictorial review. AJR Am J Roentgenol. 197:W392–W398. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Frazier SR, Kaplan PA and Loy TS: The pathology of extrapulmonary small cell carcinoma. Semin Oncol. 34:30–38. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Li AF, Li AC, Hsu CY, Li WY, Hsu HS and Chen JY: Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol. 63:620–625. 2010. View Article : Google Scholar : PubMed/NCBI

15 

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Small Cell Lung Cancer. 2012.http://www.nccn.org/professionals/physician_gls/pdf/sclc.pdf. Accessed October 2, 2012.

16 

Kanzaki M, Muto Y, Yoshinouchi S, Maeda M, Miyoshi S and Teshima S: A case of esophageal small cell carcinoma with syndrome of inappropriate antidiuretic hormone secretion. Gan To Kagaku Ryoho. 37:1941–1944. 2010.PubMed/NCBI

17 

Mizuiri H, Hihara J and Okada M: CDDP+CPT-11 therapy is useful for stage IVb esophageal small cell carcinoma. Gan To Kagaku Ryoho. 36:831–834. 2009.

18 

Nakajima S, Hidaka H, Umekita Y, Uchiyama S, Kataoka H and Chijiiwa K: A 4-year survivor of small cell carcinoma of the esophagus with liver metastases managed by multidisciplinary treatment. J Jpn Surg Assoc. 64:1605–1610. 2009.

19 

Matsuoka M, Boku N, Yoshino T, Hironaka S, Onozawa Y, Fukutomi A, Zenda S, Yamazaki K, Yasui H, Hasuike N, Inui T, Yamaguchi Y, Ono H and Kamata M: Small cell carcinoma of the esophagus responding to fourth-line chemotherapy with weekly paclitaxel. Int J Clin Oncol. 10:429–432. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Tsujie M, Shibata N, Nomura T, Tanaka T, Morimoto T, Fujita S, Kitani K, Nakahira S, Okuda H and Takeda M: A patient with stage IVb small cell carcinoma of the esophagus who survived 23 months after systemic cancer chemotherapy. Gan To Kagaku Ryoho. 30:271–275. 2003.PubMed/NCBI

21 

Koide N, Hiraguri M, Kishimoto K, Nakamura T, Adachi W, Miyabayashi H, Terai N and Amano J: Small cell carcinoma of the esophagus with reference to alternating multiagent chemotherapy: report of two cases. Surg Today. 33:294–298. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Yun JP, Zhang MF, Hou JH, et al: Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases. BMC Cancer. 7:382007. View Article : Google Scholar : PubMed/NCBI

23 

Shia J, Tang LH, Weiser MR, et al: Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol. 32:719–731. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Gregory DL, Brennan SM, Stillie A, et al: Impact of 18F-fluorodeoxyglucose positron emission tomography in the staging and treatment response assessment of extra-pulmonary small-cell cancer. J Med Imaging Radiat Oncol. 54:100–107. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Vyleta M and Coldwell D: Radioembolization in the treatment of neuroendocrine tumor metastases to the liver. Int J Hepatol. 2011:7853152011.PubMed/NCBI

26 

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Neuroendocrine Tumors. 2011.http://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Accessed October 2, 2012.

27 

Raymond E, Dahan L, Raoul JL, et al: Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Eng J Med. 364:501–513. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yao JC, Shah MH, Ito T, et al; RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group: Everolimus for advanced pancreatic neuroendocrine tumors. N Eng J Med. 364:514–523. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Noda K, Nishiwaki Y, Kawahara M, et al; Japan Clinical Oncology Group: Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Eng J Med. 346:85–91. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Hanna N, Bunn PA Jr, Langer C, et al: Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol. 24:2038–2043. 2006. View Article : Google Scholar

31 

Lara PN Jr, Natale R, Crowley J, et al: Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol. 27:2530–2535. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ettinger DS, Jotte R, Lorigan P, et al: Phase II study of amrubicin as second-line therapy in patients with platinum-refractory small-cell lung cancer. J Clin Oncol. 28:2598–2603. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Onoda S, Masuda N, Seto T, et al; Thoracic Oncology Research Group Study 0301: Phase II trial of amrubicin for treatment of refractory or relapsed small-cell lung cancer: Thoracic Oncology Research Group Study 0301. J Clin Oncol. 24:5448–5453. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Asayama M, Fuse N, Yoshino T, et al: Amrubicin for the treatment of neuroendocrine carcinoma of the gastrointestinal tract: a retrospective analysis of five cases. Cancer Chemother Pharmacol. 68:1325–1330. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Kim YH and Mishima M: Second-line chemotherapy for small-cell lung cancer (SCLC). Cancer Treat Rev. 37:143–150. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Kuo CH, Hsieh CC, Chan ML, Li AF, Huang MH, Hsu WH and Hsu HS: Small cell carcinoma of the esophagus: a report of 16 cases from a single institution and literature review. Ann Thorac Surg. 91:373–378. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Funakoshi S, Hashiguchi A, Teramoto K, Miyata N, Kurita S, Adachi M, Hamamoto Y, Higuchi H, Takaishi H, Hibi T, Hibi T, et al: Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature. Oncol Lett 5: 117-122, 2013.
APA
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M. ... Hibi, T. (2013). Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature. Oncology Letters, 5, 117-122. https://doi.org/10.3892/ol.2012.1008
MLA
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M., Hamamoto, Y., Higuchi, H., Takaishi, H., Hibi, T."Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature". Oncology Letters 5.1 (2013): 117-122.
Chicago
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M., Hamamoto, Y., Higuchi, H., Takaishi, H., Hibi, T."Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature". Oncology Letters 5, no. 1 (2013): 117-122. https://doi.org/10.3892/ol.2012.1008
Copy and paste a formatted citation
x
Spandidos Publications style
Funakoshi S, Hashiguchi A, Teramoto K, Miyata N, Kurita S, Adachi M, Hamamoto Y, Higuchi H, Takaishi H, Hibi T, Hibi T, et al: Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature. Oncol Lett 5: 117-122, 2013.
APA
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M. ... Hibi, T. (2013). Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature. Oncology Letters, 5, 117-122. https://doi.org/10.3892/ol.2012.1008
MLA
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M., Hamamoto, Y., Higuchi, H., Takaishi, H., Hibi, T."Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature". Oncology Letters 5.1 (2013): 117-122.
Chicago
Funakoshi, S., Hashiguchi, A., Teramoto, K., Miyata, N., Kurita, S., Adachi, M., Hamamoto, Y., Higuchi, H., Takaishi, H., Hibi, T."Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature". Oncology Letters 5, no. 1 (2013): 117-122. https://doi.org/10.3892/ol.2012.1008
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