Clinical features of intracranial vestibular schwannomas

Huang,Xiang; Xu,Jian; Xu,Ming; Zhou,Liang‑Fu; Zhang,Rong; Lang,Liqin; Xu,Qiwu; Zhong,Ping; Chen,Mingyu; Wang,Ying; Zhang,Zhenyu

doi:10.3892/ol.2012.1011

January 2013 Volume 5 Issue 1

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January 2013 Volume 5 Issue 1

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Article

Clinical features of intracranial vestibular schwannomas

Authors:
- Xiang Huang
- Jian Xu
- Ming Xu
- Liang‑Fu Zhou
- Rong Zhang
- Liqin Lang
- Qiwu Xu
- Ping Zhong
- Mingyu Chen
- Ying Wang
- Zhenyu Zhang
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, P.R. China
Pages: 57-62
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Published online on: October 31, 2012

https://doi.org/10.3892/ol.2012.1011
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Abstract

The aim of the present study was to discuss the clinical features of intracranial vestibular schwannomas and to evaluate the symptoms and signs as well as their correlation with tumor extension. The records of 1,009 patients who were treated in Shanghai Huashan Hospital were reviewed retrospectively. According to the Samii classification of 1997, the patients were grouped into a T3 and a T4 group based on the radiological findings. We focused our analysis on the incidence of subjective disturbances versus objective morbidity, and symptomatology versus tumor size and extension. Of the 1,009 cases, 424 patients (42.0%) were defined as T3 while 585 patients (58%) were defined as T4. The most frequent clinical symptoms were hearing loss (85.8%), facial numbness (48.9%), ataxia (44.6%), tinnitus (40.1%), deafness (26.3%) and facial paralysis (21.1%). The ratios of gender, vertigo and facial paralysis were significantly different between the T3 and T4 groups (P<0.05); however, none of the clinical symptoms had a positive likelihood ratio (PLR) greater than 10 for T4 prediction. The most frequent cranial nerve disturbance was associated with the cochlear nerve (92.6%) and trigeminal nerve (53.5%). Disturbance of the facial nerve was more severe in T3 than T4 patients (P<0.05). Hearing deficit, facial paresthesia, ataxia and tinnitus are key symptoms of huge vestibular schwannomas. Cochlear, trigeminal and facial nerves were the most commonly affected cranial nerves in cases of large tumors. Gender and tumor size were associated with tumor extension. Although the predictive value was limited, the symptoms of vertigo, facial paralysis and hearing loss may be indicators of tumor growth.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical features of intracranial vestibular schwannomas

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Abstract

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