Paraneoplastic cerebellar degeneration associated with ovarian cancer

Russo,Alessia  Erika; Scalone,Simona; Leonardi,Giulia  Costanza; Scalisi,Aurora; Giorda,Giorgio; Sorio,Roberto

doi:10.3892/ol.2012.1016

Paraneoplastic cerebellar degeneration associated with ovarian cancer

Authors:
- Alessia Erika Russo
- Simona Scalone
- Giulia Costanza Leonardi
- Aurora Scalisi
- Giorgio Giorda
- Roberto Sorio
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Affiliations: Department of Biomedical Sciences, Section of Pathology and Oncology, Laboratory of Translational Oncology and Functional Genomics, University of Catania, Catania 95124, Italy, Department of Medical Oncology C, National Cancer Institute, IRCCS, Aviano 33081, Italy, Secondary Prevention and Screening Gynecological Unit, ASP, Catania 95100, Italy, Unit of Gynecologic Oncology, National Cancer Institute, IRCCS, Aviano 33081, Italy, Department of Medical Oncology C, National Cancer Institute, IRCCS, Aviano 33081, Italy
Published online on: November 7, 2012 https://doi.org/10.3892/ol.2012.1016
Pages: 681-683

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Abstract

Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD often precedes the cancer diagnosis by months to years. Here, we report the case of a 64‑year‑old woman who developed PCD symptoms, associated with high levels of anti‑Yo antibodies, one year after a previous diagnosis of ovarian cancer. Clinical features, pathogenesis and treatment of PCD associated with cancer are discussed according to previous studies.

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