Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Functional epidermal growth factor gene polymorphisms and risk of gastric cancer

  • Authors:
    • Zhen Zhan
    • Yajun Chen
    • Juan Wu
    • Junfeng Zhang
    • Shujuan Tong
    • Chunbing Zhang
    • Yaping Yang
  • View Affiliations / Copyright

    Affiliations: Department of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, P.R. China, Department of Clinical Laboratory, First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, P.R. China
  • Pages: 631-636
    |
    Published online on: November 22, 2012
       https://doi.org/10.3892/ol.2012.1041
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidermal growth factor (EGF) is critical in cancer progression and various genotypes of the EGF gene have been reported to be correlated with susceptibility to gastric cancer; however, the results are unclear. The aim of this study was to explore the associations of functional EGF gene polymorphisms and risk of gastric cancer in a Chinese population. We genotyped seven functional single-nucleotide polymorphisms (SNPs) of the EGF gene [rs3756261, rs11568835 and rs4444903 in the promoter region; rs11568943, rs2237051 and rs11569017 in the non-synonymous exon region and rs3733625 in the 3' untranslated region (UTR)] in a hospital-based case-control study, including 387 gastric cancer cases and 392 healthy controls by polymerase chain reaction-ligation detection reaction (PCR-LDR) methods. We found that individuals carrying the AG/GG genotype of rs2237051 (Ile to Met) in the exon region had an increased risk of gastric cancer (adjusted OR=1.577; 95% CI=1.163-2.138), compared with the wild-type homozygous AA genotype. The heterozygous AG/GG genotype of rs3733625 in the 3'UTR demonstrated a protective effect (adjusted OR=0.690; 95% CI=0.501-0.951), compared with the homozygous AA genotype. In addition, the effects of the two SNPs were more evident in intestinal gastric cancer (P<0.05); however, this was not case for the diffuse type (P>0.05). These findings indicate that a change in amino acids from isoleucine to methionine of rs2237051 and rs3733625 in the 3'UTR may contribute to the etiology of intestinal gastric cancer in the Chinese population.
View Figures
View References

1. 

Parkin DM, Pisani P and Ferlay J: Global cancer statistics. CA Cancer J Clin. 49:33–64. 1999. View Article : Google Scholar

2. 

Crew KD and Neugut AI: Epidemiology of upper gastrointestinal malignancies. Semin Oncol. 31:450–464. 2004. View Article : Google Scholar : PubMed/NCBI

3. 

Uemura N, Okamoto S, Yamamoto S, et al: Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345:784–789. 2001. View Article : Google Scholar : PubMed/NCBI

4. 

Lu SH, Hsieh LL, Luo FC and Weinstein IB: Amplification of the EGF receptor and c-myc genes in human esophageal cancer. Int J Cancer. 42:502–505. 1988. View Article : Google Scholar : PubMed/NCBI

5. 

Stoscheck CM and King LE: Role of epidermal growth factor in carcinogenesis. Cancer Research. 46:1030–1037. 1986.PubMed/NCBI

6. 

Yasui W, Hata J, Yokozaki H, et al: Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma. Int J Cancer. 41:211–217. 1988. View Article : Google Scholar : PubMed/NCBI

7. 

Tokunaga A, Onda M, Okuda T, et al: Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbB-2 in human gastric cancer. Cancer. 75:1418–1425. 1995. View Article : Google Scholar : PubMed/NCBI

8. 

Fenton SE, Groce NS and Lee DC: Characterization of the mouse epidermal growth factor promoter and 5′-flanking region. Role for an atypical TATA sequence. J Biol Chem. 271:30870–30878. 1996.

9. 

Mullhaupt B, Feren A, Jones A and Fodor E: DNA sequence and functional characterization of the human and rat epidermal growth factor promoter: regulation by cell growth. Gene. 50:191–200. 2000. View Article : Google Scholar : PubMed/NCBI

10. 

Zhu J, Meng X, Yan F, et al: A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population. J Hum Genet. 55:236–240. 2010. View Article : Google Scholar : PubMed/NCBI

11. 

Chen K, Wei Y, Yang H and Li B: Epidermal growth factor +61 G/A polymorphism and the risk of hepatocellular carcinoma in a Chinese population. Genet Test Mol Biomarkers. 15:251–255. 2011.

12. 

Amend KL, Elder JT, Tomsho LP, et al: EGF gene polymorphism and the risk of incident primary melanoma. Cancer Res. 64:2668–2672. 2004. View Article : Google Scholar : PubMed/NCBI

13. 

Hamai Y, Matsumura S, Matsusaki K, et al: A single nucleotide polymorphism in the 5′ untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. Pathobiology. 72:133–138. 2005.

14. 

Goto Y, Ando T, Goto H and Hamajima N: No association between EGF gene polymorphism and gastric cancer. Cancer Epidemiol Biomarkers Prev. 14:2454–2456. 2005. View Article : Google Scholar : PubMed/NCBI

15. 

Shen H, Xu Y, Qian Y, et al: Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. Int J Cancer. 88:601–606. 2000. View Article : Google Scholar : PubMed/NCBI

16. 

Shen H, Xu Y, Zheng Y, et al: Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: a case-control study. Int J Cancer. 95:332–336. 2001. View Article : Google Scholar : PubMed/NCBI

17. 

Shahbazi M, Pravica V, Nasreen N, et al: Association between functional polymorphism in EGF gene and malignant melanoma. Lancet. 359:397–401. 2002. View Article : Google Scholar : PubMed/NCBI

18. 

McCarron SL, Bateman AC, Theaker JM and Howell WM: EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma. Int J Cancer. 107:673–675. 2003.

19. 

Randerson-Moor JA, Gaut R, Turner F, et al: The relationship between the epidermal growth factor (EGF) 5′UTR variant A61G and melanoma/nevus susceptibility. J Invest Dermatol. 123:755–759. 2004.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhan Z, Chen Y, Wu J, Zhang J, Tong S, Zhang C and Yang Y: Functional epidermal growth factor gene polymorphisms and risk of gastric cancer. Oncol Lett 5: 631-636, 2013.
APA
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., & Yang, Y. (2013). Functional epidermal growth factor gene polymorphisms and risk of gastric cancer. Oncology Letters, 5, 631-636. https://doi.org/10.3892/ol.2012.1041
MLA
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., Yang, Y."Functional epidermal growth factor gene polymorphisms and risk of gastric cancer". Oncology Letters 5.2 (2013): 631-636.
Chicago
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., Yang, Y."Functional epidermal growth factor gene polymorphisms and risk of gastric cancer". Oncology Letters 5, no. 2 (2013): 631-636. https://doi.org/10.3892/ol.2012.1041
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan Z, Chen Y, Wu J, Zhang J, Tong S, Zhang C and Yang Y: Functional epidermal growth factor gene polymorphisms and risk of gastric cancer. Oncol Lett 5: 631-636, 2013.
APA
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., & Yang, Y. (2013). Functional epidermal growth factor gene polymorphisms and risk of gastric cancer. Oncology Letters, 5, 631-636. https://doi.org/10.3892/ol.2012.1041
MLA
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., Yang, Y."Functional epidermal growth factor gene polymorphisms and risk of gastric cancer". Oncology Letters 5.2 (2013): 631-636.
Chicago
Zhan, Z., Chen, Y., Wu, J., Zhang, J., Tong, S., Zhang, C., Yang, Y."Functional epidermal growth factor gene polymorphisms and risk of gastric cancer". Oncology Letters 5, no. 2 (2013): 631-636. https://doi.org/10.3892/ol.2012.1041
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team