Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer

Togashi,Yosuke; Masago,Katsuhiro; Ito,Yutaka; Sakamori,Yuichi; Okuda,Chiyuki; Fukuhara,Akiko; Nagai,Hiroki; Kim,Young  Hak; Mishima,Michiaki

doi:10.3892/ol.2012.1052

February 2013 Volume 5 Issue 2

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February 2013 Volume 5 Issue 2

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Article

Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer

Authors:
- Yosuke Togashi
- Katsuhiro Masago
- Yutaka Ito
- Yuichi Sakamori
- Chiyuki Okuda
- Akiko Fukuhara
- Hiroki Nagai
- Young Hak Kim
- Michiaki Mishima
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Affiliations: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
Pages: 601-604
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Published online on: November 29, 2012

https://doi.org/10.3892/ol.2012.1052
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Abstract

Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immunocompromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase chain reaction (PCR), it is unknown whether Pneumocystis colonization leads to the development of PCP. In the present study, we aimed to determine the prevalence of Pneumocystis colonization in advanced lung cancer patients. Furthermore, the association between PCP and Pneumocystis colonization was also investigated. Advanced lung cancer patients with no indication of PCP were evaluated to determine the prevalence of Pneumocystis colonization. We analyzed their oral wash (OW) samples and retrospectively evaluated advanced lung cancer patients with PCP by analyzing their sections of formalin-fixed, paraffin‑embedded lung tissues obtained following a diagnosis of lung cancer. Pneumocystis colonization was determined by a PCR test for Pneumocystis jiroveci (P. jiroveci). No P. jiroveci was detected by PCR in the OW samples of 47 advanced lung cancer patients with no indication of PCP, or in the lung tissues of four advanced lung cancer patients with PCP. These results indicate that PCP is not associated with Pneumocystis colonization in advanced lung cancer patients, although this study is limited since this was a cross-sectional and retrospective study.

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1.	Thomas CF Jr and Limper AH: Pneumocystis pneumonia. N Engl J Med. 350:2487–2498. 2004. View Article : Google Scholar
2.	Overgaard UM and Helweg-Larsen J: Pneumocystis jiroveci pneumonia (PCP) in HIV-1-negative patients: a retrospective study 2002–2004. Scand J Infect Dis. 39:589–595. 2007. View Article : Google Scholar
3.	Roblot F, Godet C, Le Moal G, et al: Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients. Eur J Clin Microbiol Infect Dis. 21:523–531. 2002. View Article : Google Scholar : PubMed/NCBI
4.	Sepkowitz KA: Opportunistic infections in patients with and patients without acquired immunodeficiency syndrome. Clin Infect Dis. 34:1098–1107. 2002. View Article : Google Scholar : PubMed/NCBI
5.	Yale SH and Limper AH: Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy. Mayo Clin Proc. 71:5–13. 1996. View Article : Google Scholar
6.	Morris A, Wei K, Afshar K and Huang L: Epidemiology and clinical significance of Pneumocystis colonization. J Infect Dis. 197:10–17. 2008. View Article : Google Scholar
7.	Wakefield AE, Pixley FJ, Banerji S, et al: Detection of Pneumocystis carinii with DNA amplification. Lancet. 336:451–453. 1990.PubMed/NCBI
8.	Rodriguez M and Fishman JA: Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients. Clin Microbiol Rev. 17:770–782. 2004.
9.	Sepkowitz KA, Brown AE and Armstrong D: Pneumocystis carinii pneumonia without acquired immunodeficiency syndrome. More patients, same risk. Arch Intern Med. 155:1125–1128. 1995. View Article : Google Scholar
10.	Sepkowitz KA, Brown AE, Telzak EE, et al: Pneumocystis carinii pneumonia among patients without AIDS at a cancer hospital. JAMA. 267:832–837. 1992. View Article : Google Scholar
11.	Torres HA, Chemaly RF, Storey R, et al: Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients. Eur J Clin Microbiol Infect Dis. 25:382–388. 2006. View Article : Google Scholar : PubMed/NCBI
12.	Vargas SL, Hughes WT, Santolaya ME, et al: Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants. Clin Infect Dis. 32:855–861. 2001.PubMed/NCBI
13.	Chen W, Gigliotti F and Harmsen AG: Latency is not an inevitable outcome of infection with Pneumocystis carinii. Infect Immun. 61:5406–5409. 1993.PubMed/NCBI
14.	Vargas SL, Hughes WT, Wakefield AE and Oz HS: Limited persistence in and subsequent elimination of Pneumocystis carinii from the lungs after P. carinii pneumonia. J Infect Dis. 172:506–510. 1995. View Article : Google Scholar : PubMed/NCBI
15.	Vogel P, Miller CJ, Lowenstine LL and Lackner AA: Evidence of horizontal transmission of Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. J Infect Dis. 168:836–843. 1993.PubMed/NCBI
16.	Maskell NA, Waine DJ, Lindley A, et al: Asymptomatic carriage of Pneumocystis jiroveci in subjects undergoing bronchoscopy: a prospective study. Thorax. 58:594–597. 2003.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer

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