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Article

Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells

  • Authors:
    • Karam Kim
    • Sungkwan An
    • Hwa Jun Cha
    • Yeong Min Choi
    • Sung Jin Choi
    • In-Sook An
    • Hong Ghi Lee
    • Yoo Hong Min
    • Su-Jae Lee
    • Seunghee Bae
  • View Affiliations / Copyright

    Affiliations: Molecular-Targeted Drug Research Center, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea, Korea Institute for Skin and Clinical Sciences, Konkuk University, Gwangjin-gu, Seoul 143-701, Republic of Korea, Department of Internal Medicine, Konkuk University College of Medicine, Seoul 143-729, Republic of Korea, Department of Internal Medicine and Center for Chronic Metabolic Disease, Yonsei University College of Medicine, Seoul 102-752, Republic of Korea, Department of Chemistry, Hanyang University, Seongdong-gu, Seoul 133-791, Republic of Korea
  • Pages: 588-592
    |
    Published online on: November 30, 2012
       https://doi.org/10.3892/ol.2012.1054
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Abstract

Non-small cell lung cancer (NSCLC) is the most deadly type of cancer worldwide. Although a number of therapies are used in NSCLC treatment, their therapeutic efficacy remains low. Lenalidomide was originally approved for use in patients with myelodysplastic syndromes, which are associated with 5q deletions, and multiple myeloma. Recently, lenalidomide was investigated as a new NSCLC treatment, and it exerted anticancer effects. However, the primary cellular mechanism of its effects in NSCLC is largely unknown. Therefore, we attempted to elucidate a molecular portrait of lenalidomide-mediated cellular events in NSCLC. Lenalidomide reduced the viability of several NSCLC cell lines in a concentration-dependent manner. In addition, array-based gene expression analysis revealed that lenalidomide regulated the expression of several genes associated with cell survival, apoptosis and development, including BH3-interacting domain death agonist (BID), v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) and NK2 homeobox1 (NKX2-1). BID and FOS, which are known apoptosis activators, were upregulated by lenalidomide treatment, whereas NKX2-1, which is used as an immunohistochemistry marker for NSCLC, was downregulated. These results provide evidence that lenalidomide directly induces antiproliferative effects by altering the expression of genes associated with cell proliferation and apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Kim K, An S, Cha HJ, Choi YM, Choi SJ, An I, Lee HG, Min YH, Lee S, Bae S, Bae S, et al: Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett 5: 588-592, 2013.
APA
Kim, K., An, S., Cha, H.J., Choi, Y.M., Choi, S.J., An, I. ... Bae, S. (2013). Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncology Letters, 5, 588-592. https://doi.org/10.3892/ol.2012.1054
MLA
Kim, K., An, S., Cha, H. J., Choi, Y. M., Choi, S. J., An, I., Lee, H. G., Min, Y. H., Lee, S., Bae, S."Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells". Oncology Letters 5.2 (2013): 588-592.
Chicago
Kim, K., An, S., Cha, H. J., Choi, Y. M., Choi, S. J., An, I., Lee, H. G., Min, Y. H., Lee, S., Bae, S."Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells". Oncology Letters 5, no. 2 (2013): 588-592. https://doi.org/10.3892/ol.2012.1054
Copy and paste a formatted citation
x
Spandidos Publications style
Kim K, An S, Cha HJ, Choi YM, Choi SJ, An I, Lee HG, Min YH, Lee S, Bae S, Bae S, et al: Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett 5: 588-592, 2013.
APA
Kim, K., An, S., Cha, H.J., Choi, Y.M., Choi, S.J., An, I. ... Bae, S. (2013). Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncology Letters, 5, 588-592. https://doi.org/10.3892/ol.2012.1054
MLA
Kim, K., An, S., Cha, H. J., Choi, Y. M., Choi, S. J., An, I., Lee, H. G., Min, Y. H., Lee, S., Bae, S."Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells". Oncology Letters 5.2 (2013): 588-592.
Chicago
Kim, K., An, S., Cha, H. J., Choi, Y. M., Choi, S. J., An, I., Lee, H. G., Min, Y. H., Lee, S., Bae, S."Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells". Oncology Letters 5, no. 2 (2013): 588-592. https://doi.org/10.3892/ol.2012.1054
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