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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Review

The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review)

  • Authors:
    • Igal Kushnir
    • Ofer Merimsky
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
  • Pages: 424-426
    |
    Published online on: December 5, 2012
       https://doi.org/10.3892/ol.2012.1065
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Abstract

Until recently, metastatic melanoma was a disease with limited treatment options and a poor prognosis. Dacarbazine was accepted as the standard treatment for melanoma in the 1970s, and despite inducing an overall survival of approximately 7.4 months, it remained so until relatively recently. In the last few years, significant advances in the molecular understanding of this disease have facilitated the development of novel and promising drugs. Precision-oriented medicine is currently revolutionizing the practice of oncology. Targeted therapies have demonstrated great potential in treating melanoma and various other types of cancer, including breast, colorectal and non-small cell lung cancer. Here, we review the evolution of melanoma treatment from single-agent chemotherapy to combination therapy, the emergence of immunotherapy in melanoma and the development of targeted therapies, such as the use of the BRAF inhibitor as a treatment agent. The ability to treat melanoma according to the fingerprint of the tumor reflects an overall change in the practice of oncology.
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Copy and paste a formatted citation
Spandidos Publications style
Kushnir I and Merimsky O: The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review). Oncol Lett 5: 424-426, 2013.
APA
Kushnir, I., & Merimsky, O. (2013). The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review). Oncology Letters, 5, 424-426. https://doi.org/10.3892/ol.2012.1065
MLA
Kushnir, I., Merimsky, O."The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review)". Oncology Letters 5.2 (2013): 424-426.
Chicago
Kushnir, I., Merimsky, O."The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review)". Oncology Letters 5, no. 2 (2013): 424-426. https://doi.org/10.3892/ol.2012.1065
Copy and paste a formatted citation
x
Spandidos Publications style
Kushnir I and Merimsky O: The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review). Oncol Lett 5: 424-426, 2013.
APA
Kushnir, I., & Merimsky, O. (2013). The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review). Oncology Letters, 5, 424-426. https://doi.org/10.3892/ol.2012.1065
MLA
Kushnir, I., Merimsky, O."The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review)". Oncology Letters 5.2 (2013): 424-426.
Chicago
Kushnir, I., Merimsky, O."The evolution in melanoma treatment as a reflection of precision-oriented medicine (Review)". Oncology Letters 5, no. 2 (2013): 424-426. https://doi.org/10.3892/ol.2012.1065
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