Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer

  • Authors:
    • Masaya Hiyoshi
    • Joji Kitayama
    • Shinsuke Kazama
    • Yoshitaka  Taketomi
    • Makoto Murakami
    • Nelson H. Tsuno
    • Kumiko  Hongo
    • Manabu  Kaneko
    • Eiji Sunami
    • Toshiaki Watanabe
  • View Affiliations / Copyright

    Affiliations: Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan, Lipid Metabolism Project, The Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan , Department of Transfusion Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
  • Pages: 533-538
    |
    Published online on: December 10, 2012
       https://doi.org/10.3892/ol.2012.1067
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Among the secretory phospholipase A2s (sPLA2), sPLA2 group X (PLA2GX) has the most potent hydrolyzing activity toward phosphatidylcholine, and has recently been shown to be implicated in chronic inflammatory diseases. The aim of the present study was to investigate PLA2GX expression in colorectal cancer (CRC) and its correlation with patient clinicopathological features. The present study comprises a series of 158 patients who underwent surgical resection for primary CRC. PLA2GX expression in CRC tissues was examined by immunohistochemistry and compared with patient clinicopathological findings and survival. A total of 64% of the tumors expressed PLA2GX at high levels. Statistical analysis revealed that PLA2GX expression was inversely correlated with hematogenous metastasis (P=0.005). In the subgroup analysis, left-sided tumors with high PLA2GX expression showed an inverse correlation with lymph node metastasis (P=0.018) and hematogenous metastasis (P=0.017). Patients with high PLA2GX expression tended to have a longer disease‑specific survival compared with those with low PLA2GX expression in left-sided, but not right-sided, CRC (P=0.08). In light of the present results, we suggest that PLA2GX has an inhibitory effect on the progression of CRC.
View Figures

Figure 1

Figure 2

View References

1. 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2. 

Williams CS, Tsujii M, Reese J, Dey SK and DuBois RN: Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest. 105:1589–1594. 2000. View Article : Google Scholar : PubMed/NCBI

3. 

Rodrigues S, Bruyneel E, Rodrigue CM, Shahin E and Gespach C: Cyclooxygenase 2 and carcinogenesis. Bull Cancer. 91(Suppl 2): S61–S76. 2004.(In French).

4. 

Murakami M, Taketomi Y, Sato H and Yamamoto K: Secreted phospholipase A2 revisited. J Biochem. 150:233–255. 2011. View Article : Google Scholar

5. 

Lambeau G and Gelb MH: Biochemistry and physiology of mammalian secreted phospholipases A2. Annu Rev Biochem. 77:495–520. 2008. View Article : Google Scholar : PubMed/NCBI

6. 

Touqui L and Wu YZ: Interaction of secreted phospholipase A2 and pulmonary surfactant and its pathophysiological relevance in acute respiratory distress syndrome. Acta Pharmacol Sin. 24:1292–1296. 2003.PubMed/NCBI

7. 

Triggiani M, Granata F, Frattini A and Marone G: Activation of human inflammatory cells by secreted phospholipases A2. Biochim Biophys Acta. 1761:1289–1300. 2006. View Article : Google Scholar : PubMed/NCBI

8. 

Nevalainen TJ, Graham GG and Scott KF: Antibacterial actions of secreted phospholipases A2. Review. Biochim Biophys Acta. 1781:1–9. 2008. View Article : Google Scholar : PubMed/NCBI

9. 

Hanasaki K, Ono T, Saiga A, et al: Purified group X secretory phospholipase A(2) induced prominent release of arachidonic acid from human myeloid leukemia cells. J Biol Chem. 274:34203–34211. 1999. View Article : Google Scholar

10. 

Murakami M, Kambe T, Shimbara S, et al: Different functional aspects of the group II subfamily (Types IIA and V) and type X secretory phospholipase A(2)s in regulating arachidonic acid release and prostaglandin generation. Implications of cyclooxygenase-2 induction and phospholipid scramblase-mediated cellular membrane perturbation. J Biol Chem. 274:31435–31444. 1999.

11. 

Morioka Y, Ikeda M, Saiga A, et al: Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis. FEBS Lett. 487:262–266. 2000. View Article : Google Scholar : PubMed/NCBI

12. 

Surrel F, Jemel I, Boilard E, et al: Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators. Mol Pharmacol. 76:778–790. 2009. View Article : Google Scholar : PubMed/NCBI

13. 

Mounier CM, Wendum D, Greenspan E, Fléjou JF, Rosenberg DW and Lambeau G: Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate. Br J Cancer. 98:587–595. 2008. View Article : Google Scholar : PubMed/NCBI

14. 

Tribler L, Jensen LT, Jørgensen K, et al: Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue. Anticancer Res. 27:3179–3185. 2007.PubMed/NCBI

15. 

Degousee N, Ghomashchi F, Stefanski E, et al: Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. J Biol Chem. 277:5061–5073. 2002. View Article : Google Scholar : PubMed/NCBI

16. 

Masuda S, Murakami M, Matsumoto S, et al: Localization of various secretory phospholipase A2 enzymes in male reproductive organs. Biochim Biophys Acta. 1686:61–76. 2004. View Article : Google Scholar : PubMed/NCBI

17. 

Murakami M, Taketomi Y, Miki Y, Sato H, Hirabayashi T and Yamamoto K: Recent progress in phospholipase A2 research: from cells to animals to humans. Prog Lipid Res. 50:152–192. 2011.

18. 

Murakami M, Masuda S, Shimbara S, Ishikawa Y, Ishii T and Kudo I: Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2). J Biol Chem. 280:24987–24998. 2005. View Article : Google Scholar : PubMed/NCBI

19. 

Yamashita S, Yamashita J, Sakamoto K, et al: Increased expression of membrane-associated phospholipase A2 shows malignant potential of human breast cancer cells. Cancer. 71:3058–3064. 1993. View Article : Google Scholar

20. 

Yamashita S, Yamashita J and Ogawa M: Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency. Br J Cancer. 69:1166–1170. 1994. View Article : Google Scholar : PubMed/NCBI

21. 

Kiyohara H, Egami H, Kako H, et al: Immunohistochemical localization of group II phospholipase A2 in human pancreatic carcinomas. Int J Pancreatol. 13:49–57. 1993.PubMed/NCBI

22. 

Jiang J, Neubauer BL, Graff JR, et al: Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma. Am J Pathol. 160:667–671. 2002. View Article : Google Scholar : PubMed/NCBI

23. 

Dong Q, Patel M, Scott KF, Graham GG, Russell PJ and Sved P: Oncogenic action of phospholipase A2 in prostate cancer. Cancer Lett. 240:9–16. 2006. View Article : Google Scholar : PubMed/NCBI

24. 

Ying Z, Tojo H, Komatsubara T, et al: Enhanced expression of group II phospholipase A2 in human hepatocellular carcinoma. Biochim Biophys Acta. 1226:201–205. 1994. View Article : Google Scholar : PubMed/NCBI

25. 

Leung SY, Chen X, Chu KM, et al: Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci USA. 99:16203–16208. 2002. View Article : Google Scholar : PubMed/NCBI

26. 

Xing XF, Li H, Zhong XY, et al: Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer. Histopathology. 59:198–206. 2011.PubMed/NCBI

27. 

Buhmeida A, Bendardaf R, Hilska M, et al: PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma. Ann Oncol. 20:1230–1235. 2009. View Article : Google Scholar : PubMed/NCBI

28. 

Kashiwagi M, Friess H, Uhl W, et al: Group II and IV phospholipase A(2) are produced in human pancreatic cancer cells and influence prognosis. Gut. 45:605–612. 1999. View Article : Google Scholar : PubMed/NCBI

29. 

Ganesan K, Ivanova T, Wu Y, et al: Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. Cancer Res. 68:4277–4286. 2008. View Article : Google Scholar : PubMed/NCBI

30. 

Graff JR, Konicek BW, Deddens JA, et al: Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade. Clin Cancer Res. 7:3857–3861. 2001.PubMed/NCBI

31. 

Chan TA, Morin PJ, Vogelstein B and Kinzler KW: Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci USA. 95:681–686. 1998. View Article : Google Scholar : PubMed/NCBI

32. 

Reddy BS: Chemoprevention of colon cancer by dietary fatty acids. Cancer Metastasis Rev. 13:285–302. 1994. View Article : Google Scholar : PubMed/NCBI

33. 

Bendardaf R, Lamlum H, Ristämaki R, Korkeila E, Syrjänen K and Pyrhönen S: Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. Tumour Biol. 28:212–220. 2007. View Article : Google Scholar : PubMed/NCBI

34. 

Bendardaf R, Lamlum H, Ristamäki R, Korkeila E, Syrjänen K and Pyrhönen S: Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. Acta Oncol. 47:1046–1053. 2008. View Article : Google Scholar : PubMed/NCBI

35. 

Cummings BS: Phospholipase A2 as targets for anti-cancer drugs. Biochem Pharmacol. 74:949–959. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hiyoshi M, Kitayama J, Kazama S, Taketomi Y, Murakami M, Tsuno NH, Hongo K, Kaneko M, Sunami E, Watanabe T, Watanabe T, et al: The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. Oncol Lett 5: 533-538, 2013.
APA
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N.H. ... Watanabe, T. (2013). The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. Oncology Letters, 5, 533-538. https://doi.org/10.3892/ol.2012.1067
MLA
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T."The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer". Oncology Letters 5.2 (2013): 533-538.
Chicago
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T."The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer". Oncology Letters 5, no. 2 (2013): 533-538. https://doi.org/10.3892/ol.2012.1067
Copy and paste a formatted citation
x
Spandidos Publications style
Hiyoshi M, Kitayama J, Kazama S, Taketomi Y, Murakami M, Tsuno NH, Hongo K, Kaneko M, Sunami E, Watanabe T, Watanabe T, et al: The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. Oncol Lett 5: 533-538, 2013.
APA
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N.H. ... Watanabe, T. (2013). The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. Oncology Letters, 5, 533-538. https://doi.org/10.3892/ol.2012.1067
MLA
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T."The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer". Oncology Letters 5.2 (2013): 533-538.
Chicago
Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T."The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer". Oncology Letters 5, no. 2 (2013): 533-538. https://doi.org/10.3892/ol.2012.1067
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team