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Article

Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion

  • Authors:
    • Xinshan Cao
    • Xingyue Jiang
  • View Affiliations / Copyright

    Affiliations: Radioactive Department, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China
  • Pages: 511-514
    |
    Published online on: December 10, 2012
       https://doi.org/10.3892/ol.2012.1068
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Abstract

The aim of this study was to investigate the changes of the multislice computed tomography (MSCT) perfusion parameters and histopathology of the liver in rabbits with VX2 tumors before and after high-intensity focused ultrasound (HIFU) therapy. VX2 carcinoma cells were implanted into the livers of eight New Zealand white rabbits 3 weeks prior to the treatment. MSCT perfusion was performed one week before and one and six weeks after the treatment. These CT perfusion (CTP) data, including hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT) and permeability-surface area product (PS), were analyzed semi-quantitatively and qualitatively. Furthermore, the histopathological features of the liver tissues were also assessed semi-quantitatively before and after the treatment. Six weeks after HIFU therapy, MTT increased noticeably from 5.45±0.27 to 10.38±2.22 sec (P<0.05) and PS decreased significantly from 79.03±3.41 to 68.13±0.21 ml/100 g/min (P<0.05), while no significant differences in HBF and HBV were found. Furthermore, more CD3+ T cells were observed at the rim and center of the liver tumors six weeks after treatment. Therefore, HIFU therapy may be a simple and effective method for the treatment of liver tumors. CTP, as an effective method to obtain functional information about HBF, is able to quantify tumor vascularity and angiogenesis in liver tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Cao X and Jiang X: Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion. Oncol Lett 5: 511-514, 2013.
APA
Cao, X., & Jiang, X. (2013). Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion. Oncology Letters, 5, 511-514. https://doi.org/10.3892/ol.2012.1068
MLA
Cao, X., Jiang, X."Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion". Oncology Letters 5.2 (2013): 511-514.
Chicago
Cao, X., Jiang, X."Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion". Oncology Letters 5, no. 2 (2013): 511-514. https://doi.org/10.3892/ol.2012.1068
Copy and paste a formatted citation
x
Spandidos Publications style
Cao X and Jiang X: Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion. Oncol Lett 5: 511-514, 2013.
APA
Cao, X., & Jiang, X. (2013). Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion. Oncology Letters, 5, 511-514. https://doi.org/10.3892/ol.2012.1068
MLA
Cao, X., Jiang, X."Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion". Oncology Letters 5.2 (2013): 511-514.
Chicago
Cao, X., Jiang, X."Evaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion". Oncology Letters 5, no. 2 (2013): 511-514. https://doi.org/10.3892/ol.2012.1068
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