Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer

  • Authors:
    • Chan Kwon Jung
    • Won Kyung Kang
    • Jae Myung Park
    • Hyo Jun Ahn
    • Sang Woo Kim
    • Seong Taek Oh
    • Kyu Yong Choi
  • View Affiliations

  • Published online on: December 18, 2012     https://doi.org/10.3892/ol.2012.1081
  • Pages: 870-876
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Abstract

The cannabinoid system has been considered to be a potential target of colorectal carcinoma therapy. The aim of this study was to address the correlation between cannabinoid type 1 (CB1) receptor expression and disease severity/outcomes in patients with colorectal cancer (CRC). CB1 receptor expression was analyzed by immunohistochemistry using tissue microarrays in consecutive patients who underwent surgical resection (n=534). CB1 receptor expression was categorized as a high (≥66%) vs. low (<66%) immunopercentage as a median split, and was analyzed in relation to disease severity and overall survival. CB1 receptor expression was observed in 409 patients (76.6%). Low CB1 receptor expression was more frequently identified in stage IV than in stage I/II or III cancer (P<0.01 for both). In stage IV CRC, high vs. low CB1 expression was correlated with a statistically significant poorer overall survival (P=0.033) that was independent of age, R0 resection, tumor differentiation and chemotherapy [hazard ratio (HR), 1.805; 95% confidence interval (CI), 1.042-3.094; P=0.035]. However, CB1 expression was not observed to be correlated with patient survival following surgery in stage I/II or III cancer. The high immunoreactivity of the cannabinoid type 1 receptor is a significant prognostic factor following surgery in stage IV CRC.
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March 2013
Volume 5 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jung CK, Kang WK, Park JM, Ahn HJ, Kim SW, Oh ST and Choi KY: Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer. Oncol Lett 5: 870-876, 2013
APA
Jung, C.K., Kang, W.K., Park, J.M., Ahn, H.J., Kim, S.W., Oh, S.T., & Choi, K.Y. (2013). Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer. Oncology Letters, 5, 870-876. https://doi.org/10.3892/ol.2012.1081
MLA
Jung, C. K., Kang, W. K., Park, J. M., Ahn, H. J., Kim, S. W., Oh, S. T., Choi, K. Y."Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer". Oncology Letters 5.3 (2013): 870-876.
Chicago
Jung, C. K., Kang, W. K., Park, J. M., Ahn, H. J., Kim, S. W., Oh, S. T., Choi, K. Y."Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer". Oncology Letters 5, no. 3 (2013): 870-876. https://doi.org/10.3892/ol.2012.1081