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Article

Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer

  • Authors:
    • Min-Jeong Kim
    • Seung-Gu Yeo
    • Eun Seok Kim
    • Chul Kee Min
    • Pyung Se An
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea, Department of Radiation Oncolocy, Soonchunhyang University Hospital, Cheonan, Republic of Korea, Department of Radiation Oncology, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea
  • Pages: 840-844
    |
    Published online on: December 18, 2012
       https://doi.org/10.3892/ol.2012.1082
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Abstract

This study aimed to investigate the clinical outcomes of intensity-modulated radiotherapy (IMRT)-based stereotactic body radiotherapy (SBRT) for patients with stage I non-small cell lung cancer (NSCLC). A prospective database of 16 consecutive patients receiving SBRT for pathologically-proven and peripherally-located stage I NSCLC was reviewed. Fifteen patients were medically inoperable and one patient refused to undergo surgery. The median age of the patients was 76 years (range, 69-86). Treatment planning used four-dimensional computed tomography and fixed-field IMRT (n=11) or volumetric-modulated arc therapy (VMAT; n=5). The SBRT scheme was 48 Gy in four fractions (n=9) or 55 Gy in five fractions (n=7), delivered on consecutive days. The overall response rate at 6 months was 78.6%, including a complete response in three (21.4%) patients and a partial response in eight (57.1%). Three patients (21.4%) demonstrated a stable disease status. The median follow-up time was 14 months (range, 6-20) for the surviving patients. One patient developed local failure at 11 months, while another suffered from regional failure in a subcarinal lymph node at 4 months. Two patients did not survive within the first 6 months; one patient died during salvage chemotherapy for mediastinal lymph node metastasis and the other succumbed to a cause unrelated to lung cancer. The Kaplan-Meier estimates of local failure-free, progression-free and overall survival rates at 18 months were 91.0, 85.2 and 87.5%, respectively. The toxicity was mild; no severe (grade ≥3) toxicity was identified. IMRT-based (including VMAT) delivery of SBRT for patients with stage I NSCLC demonstrated favorable responses and local control without severe toxicity.
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Copy and paste a formatted citation
Spandidos Publications style
Kim M, Yeo S, Kim ES, Min CK and An PS: Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer. Oncol Lett 5: 840-844, 2013.
APA
Kim, M., Yeo, S., Kim, E.S., Min, C.K., & An, P.S. (2013). Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer. Oncology Letters, 5, 840-844. https://doi.org/10.3892/ol.2012.1082
MLA
Kim, M., Yeo, S., Kim, E. S., Min, C. K., An, P. S."Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer". Oncology Letters 5.3 (2013): 840-844.
Chicago
Kim, M., Yeo, S., Kim, E. S., Min, C. K., An, P. S."Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer". Oncology Letters 5, no. 3 (2013): 840-844. https://doi.org/10.3892/ol.2012.1082
Copy and paste a formatted citation
x
Spandidos Publications style
Kim M, Yeo S, Kim ES, Min CK and An PS: Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer. Oncol Lett 5: 840-844, 2013.
APA
Kim, M., Yeo, S., Kim, E.S., Min, C.K., & An, P.S. (2013). Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer. Oncology Letters, 5, 840-844. https://doi.org/10.3892/ol.2012.1082
MLA
Kim, M., Yeo, S., Kim, E. S., Min, C. K., An, P. S."Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer". Oncology Letters 5.3 (2013): 840-844.
Chicago
Kim, M., Yeo, S., Kim, E. S., Min, C. K., An, P. S."Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer". Oncology Letters 5, no. 3 (2013): 840-844. https://doi.org/10.3892/ol.2012.1082
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