Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature

Gao,Jie; Fei,Liming; Li,Sheng; Cui,Kai; Zhang,Jianbo; Yu,Fachang; Zhang,Bo

doi:10.3892/ol.2012.1087

March 2013 Volume 5 Issue 3

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March 2013 Volume 5 Issue 3

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Case Report

Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature

Authors:
- Jie Gao
- Liming Fei
- Sheng Li
- Kai Cui
- Jianbo Zhang
- Fachang Yu
- Bo Zhang
View Affiliations / Copyright

Affiliations: Department of Hepatobiliary Surgery, Shandong Cancer Hospital, Jinan 250117, P.R. China, Department of Hepatobiliary Surgery, Yantaishan Hospital, Yantai 264025, P.R. China, Key Laboratory for Rare and Uncommon Diseases of Shandong, Shandong 250062, P.R. China, Department of Pathology, Shandong Cancer Hospital, Jinan 250117, P.R. China, Shandong Academy of Medical Sciences, Shandong 250031, P.R. China
Pages: 739-742
|
Published online on: December 19, 2012

https://doi.org/10.3892/ol.2012.1087
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Abstract

Over 200 cases of undifferentiated embryonal sarcoma of the liver (UESL) have been reported since 1978 when this disease was first described. In the present study, we describe a case of UESL in a 7-year-old female, whose initial symptoms included swelling in the upper abdomen and a palpable enormous irregular tumor. A magnetic resonance imaging (MRI) examination revealed a massive focal lesion in the right lobe of the liver. Hepatic malignant tumor with a high possibility of hepatoblastoma was diagnosed. The tumor was surgically removed and confirmed to be UESL by postoperative pathology and immunohistochemical staining analysis. The patient then received chemotherapy consisting of three cycles of epirubicin (20 mg, days 1-2) and cisplatin (15 mg, days 1-3). To date, the patient has survived for 22 months, and is currently in a good general condition without evidence of local metastasis or recurrence. Although UESL has a high malignancy and a poor prognosis, cases of long-term survival with improved diagnosis and therapy have recently been reported. Therefore, it has been proposed that UESL should not be considered as an hepatic tumor with a poor prognosis. Total resection with preoperative or postoperative radio-chemotherapy is currently considered to be the key approach to improving the survival rate.

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1	Stocker JT and Ishak KG: Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. Cancer. 42:336–348. 1978. View Article : Google Scholar : PubMed/NCBI
2	Faraj W, Mukherji D, El Majzoub N, Shamseddine A, Shamseddine A and Khalife M: Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. World J Surg Oncol. 8:582010. View Article : Google Scholar : PubMed/NCBI
3	Li XW, Gong SJ, Song WH, Zhu JJ, Pan CH, Wu MC and Xu AM: Undifferentiated liver embryonal sarcoma in adults: a report of four cases and literature review. World J Gastroenterol. 16:4725–4732. 2010. View Article : Google Scholar : PubMed/NCBI
4	Lee MK, Kwon CG, Hwang KH, Choe W, Kim JE, Tchah H and Jeon IS: F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. Clin Nucl Med. 34:107–108. 2009. View Article : Google Scholar : PubMed/NCBI
5	Uchiyama M, Iwafuchi M, Yagi M, Iinuma Y, Kanada S, Yamazaki S, Ohtaki M and Shirai Y: Treatment of ruptured undifferentiated sarcoma of the liver in children: a report of two cases and review of the literature. J Hepatobiliary Pancreat Surg. 8:87–91. 2001. View Article : Google Scholar : PubMed/NCBI
6	Pachera S, Nishio H, Takahashi Y, Yokoyama Y, Oda K, Ebata T, Igami T and Nagino M: Undifferentiated embryonal sarcoma of the liver: case report and literature survey. J Hepatobiliary Pancreat Surg. 15:536–544. 2008. View Article : Google Scholar : PubMed/NCBI
7	Webber EM, Morrison KB, Pritchard SL and Sorensen PH: Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. J Pediatr Surg. 34:1641–1644. 1999. View Article : Google Scholar : PubMed/NCBI
8	Sangkhathat S, Kusafuka T, Nara K, Yoneda A and Fukuzawa M: Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. Hepatol Res. 35:229–234. 2006. View Article : Google Scholar : PubMed/NCBI
9	Bisogno G, Pilz T, Perilongo G, Ferrari A, Harms D, Ninfo V, Treuner J and Carli M: Undifferentiated sarcoma of the liver in childhood: a curable disease. Cancer. 94:252–257. 2002. View Article : Google Scholar : PubMed/NCBI
10	Yu DC, Tandon R, Bohlke AK, Steiner RB, Haque S and Florman SS: Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. J La State Med Soc. 161:41–44. 2009.PubMed/NCBI
11	McCarthy FP, Harris M and Kornman L: Management of undifferentiated embryonal sarcoma of the liver in pregnancy. Obstet Gynecol. 109:558–560. 2007. View Article : Google Scholar : PubMed/NCBI
12	Kelly MJ, Martin L, Alonso M and Altura RA: Liver transplant for relapsed undifferentiated embryonal sarcoma in a young child. J Pediatr Surg. 44:e1–e3. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature

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Abstract

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