Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery

  • Authors:
    • Qing Zhang
    • Xiao-Shun Jin
    • Zhong-Yin Yang
    • Min Wei
    • Xiao‑Cheng Zhu
    • Ping Wang
    • Bing-Ya Liu
    • Qin-Long Gu
  • View Affiliations

  • Published online on: December 27, 2012     https://doi.org/10.3892/ol.2012.1092
  • Pages: 896-902
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Abstract

Lysyl oxidase (LOX) initiates the enzymatic stage of collagen and elastin cross-linking. It also has intracellular functions involved in the regulation of cell differentiation, motility/migration and gene transcription. Aberrant expression of the LOX gene has been reported in multiple tumors. However, the correlation of its expression with clinicopathological parameters and its prognostic significance in gastric cancer remains largely unknown. In order to address this problem, total RNA of paired tissue samples (n=10) and a tissue microarray containing 161 paired tissues from patients with gastric cancers at different stages were collected. Quantitative real-time PCR and immunochemistry assay were conducted to investigate the expression of LOX. Based on the results, LOX mRNA was increased in gastric cancer tissues compared with the adjacent normal mucosa. Immunohistochemical detection revealed that expression of LOX was associated with depth of tumor invasion (P<0.05), lymph node status (P<0.05), TNM stage (P<0.05) and survival (P<0.05). Cox regression analysis revealed that positive expression of LOX (P=0.026) was an independent prognostic marker for survival in patients with gastric cancer.
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March 2013
Volume 5 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Q, Jin X, Yang Z, Wei M, Zhu XC, Wang P, Liu B and Gu Q: Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery. Oncol Lett 5: 896-902, 2013
APA
Zhang, Q., Jin, X., Yang, Z., Wei, M., Zhu, X., Wang, P. ... Gu, Q. (2013). Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery. Oncology Letters, 5, 896-902. https://doi.org/10.3892/ol.2012.1092
MLA
Zhang, Q., Jin, X., Yang, Z., Wei, M., Zhu, X., Wang, P., Liu, B., Gu, Q."Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery". Oncology Letters 5.3 (2013): 896-902.
Chicago
Zhang, Q., Jin, X., Yang, Z., Wei, M., Zhu, X., Wang, P., Liu, B., Gu, Q."Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgery". Oncology Letters 5, no. 3 (2013): 896-902. https://doi.org/10.3892/ol.2012.1092