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Article

The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy

  • Authors:
    • Yong-Ping Liu
    • Yang Ling
    • Qiu-Feng Qi
    • Ya-Ping Zhang
    • Chang‑Song Zhang
    • Chang-Tai Zhu
    • Mei-Hua Wang
    • Yao-Dong Pan
  • View Affiliations / Copyright

    Affiliations: Clinical Oncology Laboratory, Changzhou Tumor Hospital Affiliated to Suzhou University, Changzhou 213002, P.R. China, Department of Pathology, Changzhou Tumor Hospital Affiliated to Suzhou University, Changzhou 213002, P.R. China, Department of Gastroenterological Surgery, Changzhou Tumor Hospital Affiliated to Suzhou University, Changzhou 213002, P.R. China
  • Pages: 935-942
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/ol.2012.1096
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Abstract

Excision repair cross-complementing 1 (ERCC1) is reported to be involved in the sensitivity of cancer cells to platinum-based chemotherapy. The present study was designed to evaluate the effects of ERCC1 expression on the chemosensitivity of platinum agents in gastric cancer cell lines, and on survival in gastric cancer patients treated with surgery followed by oxaliplatin-based adjuvant chemotherapy. ERCC1 expression levels were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot analysis, respectively. The chemosensitivity of a series of gastric cancer cell lines to platinum agents in vitro was evaluated using CellTiter 96 Aqueous One Solution Cell Proliferation Assay kit. The apoptotic effect of the drugs was evaluated by double staining with Annexin-V-fluorescein isothiocyanate (FITC) and propidium iodide (PI). The results demonstrated that the expression levels of ERCC1 mRNA were correlated with the chemosensitivity of platinum agents, and depletion of ERCC1 sensitized the relatively resistant MKN45 cells to cisplatin and oxaliplatin. Univariate analyses revealed that patients with low ERCC1 levels had longer relapse‑free survival (RFS) and overall survival (OS) than those with high ERCC1 levels (median RFS, 18 vs. 7 months, P=0.001; median OS, 27 vs. 11 months, P=0.001). Multivariate analyses suggested that high ERCC1 expression is an independent prognostic marker of poor RFS [hazard ratio (HR), 2.16; 95% confidence interval (CI), 1.09‑4.25; P=0.026] and OS (HR, 2.21; 95% CI, 1.07-4.55; P=0.031). These results suggest that overexpression of ERCC1 is correlated with platinum drug resistance in gastric cancer cells, and that depletion of ERCC1 sensitizes gastric cancer cell lines to cisplatin and oxaliplatin. Gastric cancer patients with low levels of ERCC1 expression demonstrate a benefit from oxaliplatin-based adjuvant chemotherapy.
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1 

Leung WK, Wu MS, Kakugawa Y, et al: Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 9:279–287. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Macdonald JS: Treatment of localized gastric cancer. Semin Oncol. 31:566–573. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Carrato A, Gallego-Plazas J and Guillen-Ponce C: Adjuvant therapy of resected gastric cancer is necessary. Semin Oncol. 32:S105–S108. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Chipponi J, Huguier M, Pezet D, et al: Randomized trial of adjuvant chemotherapy after curative resection for gastric cancer. Am J Surg. 187:440–445. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Topuz E, Basaran M, Saip P, et al: Adjuvant intraperitoneal chemotherapy with cisplatinum, mitoxantrone, 5-fluorouracil, and calcium folinate in patients with gastric cancer: a phase II study. Am J Clin Oncol. 25:619–624. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Mamenta EL, Poma EE, Kaufmann WK, Delmastro DA, Grady HL and Chaney SG: Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 54:3500–3505. 1994.PubMed/NCBI

8 

Extra JM, Espie M, Calvo F, Ferme C, Mignot L and Marty M: Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol. 25:299–303. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Louvet C, André T, Tigaud JM, et al: Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol. 20:4543–4548. 2002. View Article : Google Scholar : PubMed/NCBI

10 

De Vita F, Orditura M, Matano E, et al: A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. Br J Cancer. 92:1644–1649. 2005.PubMed/NCBI

11 

Al-Batran SE, Atmaca A, Hegewisch-Becker S, et al: Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer. J Clin Oncol. 22:658–663. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Lordick F, Lorenzen S, Stollfuss J, et al: Phase II study of weekly oxaliplatin plus infusional fluorouracil and folinic acid (FUFOX regimen) as first-line treatment in metastatic gastric cancer. Br J Cancer. 93:190–194. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Cavanna L, Artioli F, Codignola C, et al: Oxaliplatin in combination with 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic gastric cancer (MGC). Am J Clin Oncol. 29:371–375. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Wei Q, Frazier ML and Levin B: DNA repair: a double-edged sword. J Natl Cancer Inst. 92:440–441. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Woynarowski JM, Faivre S, Herzig MC, et al: Oxaliplatin-induced damage of cellular DNA. Mol Pharmacol. 58:920–927. 2000.PubMed/NCBI

16 

Reed E: ERCC1 and clinical resistance to platinum-based therapy. Clin Cancer Res. 11:6100–6102. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Nuñez F, Chipchase MD, Clarke AR and Melton DW: Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21. FASEB J. 14:1073–1082. 2000.PubMed/NCBI

18 

Cobo M, Isla D, Massuti B, et al: Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: a phase III trial in non-small-cell lung cancer. J Clin Oncol. 25:2747–2754. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Olaussen KA, Dunant A, Fouret P, et al: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med. 355:983–991. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Weberpals J, Garbuio K, O’Brien A, et al: The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer. Int J Cancer. 124:806–815. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Denlinger CS and Cohen SJ: Progress in the development of prognostic and predictive markers for gastrointestinal malignancies. Curr Treat Options Oncol. 8:339–351. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Iqbal S, Stoehlmacher J and Lenz HJ: Tailored chemotherapy for colorectal cancer: a new approach to therapy. Cancer Invest. 22:762–773. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Höfler H, Langer R, Ott K and Keller G: Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract. Adv Exp Med Biol. 587:115–120. 2006.

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Boku N: Perspectives for personalization in chemotherapy of advanced gastric cancer. Discov Med. 9:84–89. 2010.PubMed/NCBI

26 

Mauer AM, Kraut EH, Krauss SA, et al: Phase II trial of oxaliplatin, leucovorin and fluorouracil in patients with advanced carcinoma of the esophagus. Ann Oncol. 16:1320–1325. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Suo Z, Lippard SJ and Johnson KA: Single d(GpG)/cis-diammineplatinum(II) adduct-induced inhibition of DNA polymerization. Biochemistry. 38:715–726. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Selvakumaran M, Pisarcik DA, Bao R, Yeung AT and Hamilton TC: Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Cancer Res. 63:1311–1316. 2003.PubMed/NCBI

29 

Sun JM, Ahn MJ, Park MJ, et al: Expression of excision repair cross-complementation group 1 as predictive marker for nasopharyngeal cancer treated with concurrent chemoradiotherapy. Int J Radiat Oncol Biol Phys. 80:655–660. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Hwang IG, Ahn MJ, Park BB, et al: ERCC1 expression as a prognostic marker in N2(+) nonsmall-cell lung cancer patients treated with platinum-based neoadjuvant concurrent chemoradiotherapy. Cancer. 113:1379–1386. 2008.

31 

Jun HJ, Ahn MJ, Kim HS, et al: ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation. Br J Cancer. 99:167–172. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Kwon HC, Roh MS, Oh SY, et al: Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer. Ann Oncol. 18:504–509. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Kim MK, Cho KJ, Kwon GY, et al: ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer. Eur J Cancer. 44:54–60. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Chang IY, Kim MH, Kim HB, et al: Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin. Biochem Biophys Res Commun. 327:225–233. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Song L, Ritchie AM, McNeil EM, Li W and Melton DW: Identification of DNA repair gene Ercc1 as a novel target in melanoma. Pigment Cell Melanoma Res. 24:966–971. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Sancar A: Excision repair in mammalian cells. J Biol Chem. 270:15915–15918. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Darcy KM, Tian C and Reed E: A Gynecologic Oncology Group study of platinum-DNA adducts and excision repair cross-complementation group 1 expression in optimal, stage III epithelial ovarian cancer treated with platinum-taxane chemotherapy. Cancer Res. 67:4474–4481. 2007. View Article : Google Scholar

38 

Kudo K, Gavin E, Das S, Amable L, Shevde LA and Reed E: Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair. Oncogene. 31:4718–4724. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Wei J, Zou Z, Qian X, et al: ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen. Br J Cancer. 98:1398–1402. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Matsubara J, Nishina T, Yamada Y, et al: Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer. Br J Cancer. 98:832–839. 2008. View Article : Google Scholar

41 

Kim JS, Kim MA, Kim TM, et al: Biomarker analysis in stage III–IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival. Br J Cancer. 100:732–738. 2009.

42 

Napieralski R, Ott K, Kremer M, et al: Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. Clin Cancer Res. 11:3025–3031. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Ling Y, Qi Q, Zhang Y, Zhang CS, Zhu C, Wang M and Pan Y: The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy. Oncol Lett 5: 935-942, 2013.
APA
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C. ... Pan, Y. (2013). The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy. Oncology Letters, 5, 935-942. https://doi.org/10.3892/ol.2012.1096
MLA
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C., Wang, M., Pan, Y."The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy". Oncology Letters 5.3 (2013): 935-942.
Chicago
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C., Wang, M., Pan, Y."The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy". Oncology Letters 5, no. 3 (2013): 935-942. https://doi.org/10.3892/ol.2012.1096
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Ling Y, Qi Q, Zhang Y, Zhang CS, Zhu C, Wang M and Pan Y: The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy. Oncol Lett 5: 935-942, 2013.
APA
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C. ... Pan, Y. (2013). The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy. Oncology Letters, 5, 935-942. https://doi.org/10.3892/ol.2012.1096
MLA
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C., Wang, M., Pan, Y."The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy". Oncology Letters 5.3 (2013): 935-942.
Chicago
Liu, Y., Ling, Y., Qi, Q., Zhang, Y., Zhang, C., Zhu, C., Wang, M., Pan, Y."The effects of ERCC1 expression levels on the chemosensitivity of gastric cancer cells to platinum agents and survival in gastric cancer patients treated with oxaliplatin‑based adjuvant chemotherapy". Oncology Letters 5, no. 3 (2013): 935-942. https://doi.org/10.3892/ol.2012.1096
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