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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March 2013 Volume 5 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Continuous morphine infusion for end-stage lung cancer patients

  • Authors:
    • Young Hak Kim
    • Chiyuki Okuda
    • Yuichi Sakamori
    • Katsuhiro Masago
    • Yosuke Togashi
    • Michiaki Mishima

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
  • Pages: 972-974
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/ol.2012.1101
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Abstract

End-stage cancer patients frequently receive continuous morphine infusion (CMI) to alleviate the various symptoms associated with cancer progression or adverse events; however, there have been a limited number of studies concerning such patients. We conducted a retrospective analysis of 79 end-stage lung cancer patients who received CMI at the Kyoto University Hospital, Kyoto, Japan between 2008 and 2010. Thirty-one patients (39%) received CMI intravenously and 48 (61%) received it subcutaneously. The patients were divided into four groups based on the indications for CMI: group A (uncontrolled pain; n=9), group B (dyspnea; n=44), group C (both dyspnea and pain; n=13) and group D (an inability to take oral medicine; n=13). The median maximum dose of morphine in groups A‑D was 60.0, 25.0, 50.0 and 15.0 mg/day, respectively. The median survival time from the start of CMI was 4 days (range 0-136). In our limited experience, pain, dyspnea and the inability to take oral medicine were identified as indications for CMI in end-stage lung cancer patients, with dyspnea being the major indication for CMI. Patients in group B (dyspnea) required a lower dose of morphine for alleviation compared with those in groups A (uncontrolled pain) and C (both dyspnea and pain). The survival time from the initiation of CMI was markedly shorter in patients with dyspnea (groups B and C) than in patients without dyspnea (group A). Further studies are required to facilitate the effective and appropriate use of CMI in end-stage lung cancer patients. Dyspnea was the major indication for CMI in end-stage lung cancer patients, and the survival time was extensively limited in such patients.
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Copy and paste a formatted citation
Spandidos Publications style
Kim YH, Okuda C, Sakamori Y, Masago K, Togashi Y and Mishima M: Continuous morphine infusion for end-stage lung cancer patients. Oncol Lett 5: 972-974, 2013.
APA
Kim, Y.H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., & Mishima, M. (2013). Continuous morphine infusion for end-stage lung cancer patients. Oncology Letters, 5, 972-974. https://doi.org/10.3892/ol.2012.1101
MLA
Kim, Y. H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., Mishima, M."Continuous morphine infusion for end-stage lung cancer patients". Oncology Letters 5.3 (2013): 972-974.
Chicago
Kim, Y. H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., Mishima, M."Continuous morphine infusion for end-stage lung cancer patients". Oncology Letters 5, no. 3 (2013): 972-974. https://doi.org/10.3892/ol.2012.1101
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YH, Okuda C, Sakamori Y, Masago K, Togashi Y and Mishima M: Continuous morphine infusion for end-stage lung cancer patients. Oncol Lett 5: 972-974, 2013.
APA
Kim, Y.H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., & Mishima, M. (2013). Continuous morphine infusion for end-stage lung cancer patients. Oncology Letters, 5, 972-974. https://doi.org/10.3892/ol.2012.1101
MLA
Kim, Y. H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., Mishima, M."Continuous morphine infusion for end-stage lung cancer patients". Oncology Letters 5.3 (2013): 972-974.
Chicago
Kim, Y. H., Okuda, C., Sakamori, Y., Masago, K., Togashi, Y., Mishima, M."Continuous morphine infusion for end-stage lung cancer patients". Oncology Letters 5, no. 3 (2013): 972-974. https://doi.org/10.3892/ol.2012.1101
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