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Article

Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma

  • Authors:
    • Akihiko Miyawaki
    • Hiroshi Hijioka
    • Ryuji Ikeda
    • Takayuki  Ishida
    • Etsuro Nozoe
    • Norifumi Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan, Department of Clinical Pharmacy and Pharmacology, Kagoshima University, Kagoshima 890-8544, Japan
  • Pages: 995-1001
    |
    Published online on: February 13, 2012
       https://doi.org/10.3892/ol.2012.606
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Abstract

We introduced concurrent neoadjuvant chemoradiotherapy (CCRT) with S-1, an oral fluoropyrimidine, as treatment for oral squamous cell carcinoma (OSCC) from October 2005. The clinical usefulness and medical safety of CCRT with S-1 (S-1 group) for OSCC were analyzed and compared with CCRT using super-selective intra-arterial infusion (AI group). The subjects in the S-1 group underwent external irradiation, at a total dose of 30 Gy, with S-1 chemotherapy. The AI group received cisplatin (CDDP) or carboplatin (CBDCA) combined with daily radiotherapy at a total dose of 40 Gy. The histological effects and disease-specific survival rates were almost equivalent in the S-1 and AI groups. Adverse events were less frequent in the S-1 group, while hematological toxicity, including anemia, thrombopenia and pharyngeal edema, was observed in the AI group. The results of this study indicate that CCRT combined with S-1 is a more effective and safer treatment for OSCC than AI.
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Copy and paste a formatted citation
Spandidos Publications style
Miyawaki A, Hijioka H, Ikeda R, Ishida T, Nozoe E and Nakamura N: Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncol Lett 3: 995-1001, 2012.
APA
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., & Nakamura, N. (2012). Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncology Letters, 3, 995-1001. https://doi.org/10.3892/ol.2012.606
MLA
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., Nakamura, N."Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma". Oncology Letters 3.5 (2012): 995-1001.
Chicago
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., Nakamura, N."Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma". Oncology Letters 3, no. 5 (2012): 995-1001. https://doi.org/10.3892/ol.2012.606
Copy and paste a formatted citation
x
Spandidos Publications style
Miyawaki A, Hijioka H, Ikeda R, Ishida T, Nozoe E and Nakamura N: Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncol Lett 3: 995-1001, 2012.
APA
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., & Nakamura, N. (2012). Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncology Letters, 3, 995-1001. https://doi.org/10.3892/ol.2012.606
MLA
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., Nakamura, N."Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma". Oncology Letters 3.5 (2012): 995-1001.
Chicago
Miyawaki, A., Hijioka, H., Ikeda, R., Ishida, T., Nozoe, E., Nakamura, N."Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma". Oncology Letters 3, no. 5 (2012): 995-1001. https://doi.org/10.3892/ol.2012.606
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