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Article

A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)

  • Authors:
    • Walid Al-Achkar
    • Abdulsamad Wafa
    • Faten Moassass
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic Energy Commission, Damascus, Syria, Jena University Hospital, Institute of Human Genetics, Jena, Germany
  • Pages: 1027-1029
    |
    Published online on: February 28, 2012
       https://doi.org/10.3892/ol.2012.623
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Abstract

The so-called Philadelphia (Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) patients. Approximately, 5-10% of these patients show complex translocations involving a third chromosome in addition to chromosomes 9 and 22. Since at present the majority of CML cases are treated with imatinib, variant rearrangements do not exhibit specific prognostic significance. However, events of therapy resistance remain to be studied. In this study, we report a unique case of CML exhibiting an uncommon t(21;22)(p12;q11). This translocation has been characterized by fluorescence in situ hybridization (FISH) and array-proven multicolor banding (aMCB). Using specific probes for the BCR and ABL genes, results of FISH showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;p12) with a BCR/ABL fusion residing on the der(22) and the 3'BCR region translocated on the short arm of the derivative chromosome 21. In addition, the aMCB technique is significant in the detection of the breakpoints of genetic changes. The underlying mechanisms and prognostic significance of these changes are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Al-Achkar W, Wafa A, Moassass F and Liehr T: A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12). Oncol Lett 3: 1027-1029, 2012.
APA
Al-Achkar, W., Wafa, A., Moassass, F., & Liehr, T. (2012). A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12). Oncology Letters, 3, 1027-1029. https://doi.org/10.3892/ol.2012.623
MLA
Al-Achkar, W., Wafa, A., Moassass, F., Liehr, T."A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)". Oncology Letters 3.5 (2012): 1027-1029.
Chicago
Al-Achkar, W., Wafa, A., Moassass, F., Liehr, T."A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)". Oncology Letters 3, no. 5 (2012): 1027-1029. https://doi.org/10.3892/ol.2012.623
Copy and paste a formatted citation
x
Spandidos Publications style
Al-Achkar W, Wafa A, Moassass F and Liehr T: A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12). Oncol Lett 3: 1027-1029, 2012.
APA
Al-Achkar, W., Wafa, A., Moassass, F., & Liehr, T. (2012). A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12). Oncology Letters, 3, 1027-1029. https://doi.org/10.3892/ol.2012.623
MLA
Al-Achkar, W., Wafa, A., Moassass, F., Liehr, T."A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)". Oncology Letters 3.5 (2012): 1027-1029.
Chicago
Al-Achkar, W., Wafa, A., Moassass, F., Liehr, T."A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12)". Oncology Letters 3, no. 5 (2012): 1027-1029. https://doi.org/10.3892/ol.2012.623
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