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Article

Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma

  • Authors:
    • Kei Kubota
    • Taiji Tamura
    • Nobutaka Aoyama
    • Munenobu Nogami
    • Norihiko Hamada
    • Akihito Nishioka
    • Yasuhiro Ogawa
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-Cho, Nankoku, Kochi 783-8505, Japan
  • Pages: 990-994
    |
    Published online on: March 1, 2012
       https://doi.org/10.3892/ol.2012.629
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Abstract

Animal studies have demonstrated that liver function parameters affect the degree of liver enhancement by gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA). The present study prospectively investigated whether liver function parameters and liver damage scores similarly correlate with the degree of liver enhancement by Gd-EOB-DTPA in humans with hepatocellular carcinoma (HCC). A total of 41 patients (32 males, 9 females; mean age, 71.9 years; range, 38-86 years) with suspected HCC provided written, informed consent to undergo a Gd-EOB-DTPA (30 µmol/kg of body weight)-enhanced T1-gradient-echo (GRE) magnetic resonance imaging (MRI) study. The signal intensity of the liver parenchyma was quantified at various time points following injection of Gd-EOB-DTPA. We investigated the correlations between maximal relative enhancement (RE) values and liver function parameters, and liver damage scores. Correlations between parameters and maximum RE values were determined using the Student's t-test and univariate regression analyses. The effect of potential confounding factors was controlled by multiple stepwise regression analysis. Two-tailed values of p<0.05 were considered to indicate a statistically significant difference. The RE values were maximal in 8 and 33 patients at 20 and 30 min, respectively, following Gd-EOB-DTPA injection and did not significantly differ between respective liver damage scores. Univariate analyses revealed that maximal RE values were associated with serum aspartate aminotransferase, total bilirubin, albumin and 15-min indocyanine green retention rates. Multiple stepwise regression analyses revealed that serum albumin and total bilirubin remained independently significant. The degree of liver parenchyma enhancement by Gd-EOB-DTPA depends on liver function parameters in humans, as in animals. The results from this study suggest that Gd-EOB-DTPA has potential for use as a liver function test, and for providing a short examination time for liver MRI results in patients with normal liver function.
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Copy and paste a formatted citation
Spandidos Publications style
Kubota K, Tamura T, Aoyama N, Nogami M, Hamada N, Nishioka A and Ogawa Y: Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncol Lett 3: 990-994, 2012.
APA
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., & Ogawa, Y. (2012). Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncology Letters, 3, 990-994. https://doi.org/10.3892/ol.2012.629
MLA
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., Ogawa, Y."Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma". Oncology Letters 3.5 (2012): 990-994.
Chicago
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., Ogawa, Y."Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma". Oncology Letters 3, no. 5 (2012): 990-994. https://doi.org/10.3892/ol.2012.629
Copy and paste a formatted citation
x
Spandidos Publications style
Kubota K, Tamura T, Aoyama N, Nogami M, Hamada N, Nishioka A and Ogawa Y: Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncol Lett 3: 990-994, 2012.
APA
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., & Ogawa, Y. (2012). Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncology Letters, 3, 990-994. https://doi.org/10.3892/ol.2012.629
MLA
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., Ogawa, Y."Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma". Oncology Letters 3.5 (2012): 990-994.
Chicago
Kubota, K., Tamura, T., Aoyama, N., Nogami, M., Hamada, N., Nishioka, A., Ogawa, Y."Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma". Oncology Letters 3, no. 5 (2012): 990-994. https://doi.org/10.3892/ol.2012.629
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