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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July 2012 Volume 4 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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Article

Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis

  • Authors:
    • Liqiang Wang
    • Jing Zhang
    • Lulu Cai
    • Jing Wen
    • Huashan  Shi
    • Dan Li
    • Fuchun Guo
    • Yongsheng Wang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Chengdu, Sichuan 610000, P.R. China, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610000, P.R. China, Department of Thoracic Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610000, P.R. China
  • Pages: 107-112
    |
    Published online on: April 19, 2012
       https://doi.org/10.3892/ol.2012.686
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Abstract

Curcumin has been proven to effectively inhibit tumor growth by both targeting tumor cells and angiogenesis; however, poor water solubility limits further clinical application. In the present study, we prepared water-soluble liposomal curcumin to investigate its anti-tumor effects and the underlying mechanism. The MTT assay was used to test the anti-proliferative activities for the MS1 murine endothelial and LL/2 Lewis lung cancer cell lines. Apoptosis and cell cycle arrest induced by liposomal curcumin were analysed by flow cytometry. Anti-angiogenic agents and the resulting anti-tumor effects were investigated in a murine lung cancer model. Zebrafish were used to investigate the anti-angiogenic effect of liposomal curcumin in the development of embryos. In vitro, liposomal curcumin inhibited the proliferation of MS1 cells and induced cell cycle arrest and apoptosis. Notably, LL/2 cells showed less sensitivity to the liposomal curcumin in vitro. In vivo, the systemic administration of liposomal curcumin resulted in significant inhibition of tumor growth. CD31 immunohistochemical analysis and alginate encapsulation assay revealed that angiogenesis was decreased by liposomal curcumin treatment. Angiogenesis was also suppressed in the development of zebrafish. Liposomal curcumin showed potent inhibitory activity against murine endothelial cells but not lung cancer cells. Liposomal curcumin treatment is capable of significantly inhibiting tumor growth in vivo, a process that may depend primarily on its anti-angiogenic effects. Our study also indicates that liposomal curcumin may be developed not only for cancer therapy, but also for the treatment of other angiogenesis-related diseases.
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1 

Pongrakhananon V, Nimmannit U, Luanpitpong S, Rojanasakul Y and Chanvorachote P: Curcumin sensitizes non-small cell lung cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation. Apoptosis. 15:574–585. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Bharti AC, Donato N, Singh S and Aggarwal BB: Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood. 101:1053–1062. 2003. View Article : Google Scholar

3 

O’Sullivan-Coyne G, O’Sullivan GC, O’Donovan TR, Piwocka K and McKenna SL: Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer. 101:1585–1595. 2009.

4 

Bhandarkar SS and Arbiser JL: Curcumin as an inhibitor of angiogenesis. Adv Exp Med Biol. 595:185–195. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Cheng AL, Hsu CH, Lin JK, et al: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21:2895–2900. 2001.PubMed/NCBI

6 

Dhillon N, Aggarwal BB, Newman RA, et al: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 14:4491–4499. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Takahashi M, Uechi S, Takara K, Asikin Y and Wada K: Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric Food Chem. 57:9141–9146. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Allen TM and Cullis PR: Drug delivery systems: entering the mainstream. Science. 303:1818–1822. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Bejjani RA, Jeanny JC, Bochot A and Behar-Cohen F: The use of liposomes as intravitreal drug delivery system. J Fr Ophtalmol. 26:981–985. 2003.(In French).

10 

Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Gasparini G, Longo R, Toi M and Ferrara N: Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat Clin Pract Oncol. 2:562–577. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Bai RZ, Wu Y, Liu Q, et al: Suppression of lung cancer in murine model: treated by combination of recombinant human endostsatin adenovirus with low-dose cisplatin. J Exp Clin Cancer Res. 28:312009. View Article : Google Scholar : PubMed/NCBI

13 

He QM: Inhibition of tumor growth with a vaccine based on xenogeneic homologous fibroblast growth factor receptor-1 in mice. J Biol Chem. 278:21831–21836. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Zheng M, Ekmekcioglu S, Walch ET, Tang CH and Grimm EA: Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. Melanoma Res. 14:165–171. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Liao S, Xia J, Chen Z, et al: Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways. J Cell Biochem. 112:1055–1065. 2011.PubMed/NCBI

16 

Tabruyn SP and Griffioen AW: A new role for NF-κB in angiogenesis inhibition. Cell Death Differ. 14:1393–1397. 2007.

17 

Wang WZ, Cheng J, Luo J and Zhuang SM: Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett. 582:2689–2695. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Yadav VR and Aggarwal BB: Curcumin: a component of the golden spice, targets multiple angiogenic pathways. Cancer Biol Ther. 11:236–241. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Wang W, Bernard K, Li G and Kirk KL: Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains. J Biol Chem. 282:4533–4544. 2007. View Article : Google Scholar

20 

Thangapazham RL, Puri A, Tele S, Blumenthal R and Maheshwari RK: Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol. 32:1119–1123. 2008.PubMed/NCBI

21 

Wang D, Veena MS, Stevenson K, et al: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 14:6228–6236. 2008. View Article : Google Scholar

22 

Mach CM, Mathew L, Mosley SA, Kurzrock R and Smith JA: Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. Anticancer Res. 29:1895–1899. 2009.PubMed/NCBI

23 

Sreekanth CN, Bava SV, Sreekumar E and Anto RJ: Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene. 30:3139–3152. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ganiger S, Malleshappa HN, Krishnappa H, Rajashekhar G, Ramakrishna Rao V and Sullivan F: A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem Toxicol. 45:64–69. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Zhang J, Cai L, Wen J, Shi H, Li D, Guo F and Wang Y: Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis. Oncol Lett 4: 107-112, 2012.
APA
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D. ... Wang, Y. (2012). Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis. Oncology Letters, 4, 107-112. https://doi.org/10.3892/ol.2012.686
MLA
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D., Guo, F., Wang, Y."Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis". Oncology Letters 4.1 (2012): 107-112.
Chicago
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D., Guo, F., Wang, Y."Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis". Oncology Letters 4, no. 1 (2012): 107-112. https://doi.org/10.3892/ol.2012.686
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Zhang J, Cai L, Wen J, Shi H, Li D, Guo F and Wang Y: Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis. Oncol Lett 4: 107-112, 2012.
APA
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D. ... Wang, Y. (2012). Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis. Oncology Letters, 4, 107-112. https://doi.org/10.3892/ol.2012.686
MLA
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D., Guo, F., Wang, Y."Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis". Oncology Letters 4.1 (2012): 107-112.
Chicago
Wang, L., Zhang, J., Cai, L., Wen, J., Shi, H., Li, D., Guo, F., Wang, Y."Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis". Oncology Letters 4, no. 1 (2012): 107-112. https://doi.org/10.3892/ol.2012.686
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