Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August 2012 Volume 4 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 2012 Volume 4 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis

  • Authors:
    • Lifang Wang
    • An Lu
    • Fanru Meng
    • Qing Cao
    • Baoen Shan
  • View Affiliations / Copyright

    Affiliations: Laboratory Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Research Center, Hebei Province Center For Disease Prevention and Control, Shijiazhuang, Hebei 050021, P.R. China, Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
  • Pages: 231-236
    |
    Published online on: May 16, 2012
       https://doi.org/10.3892/ol.2012.717
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lupeal acetate of Cortex periplocae (CPLA), a triterpene compound extracted from a traditional Chinese herb, has been identified as an inhibitor of cancer cell growth. The objective of the present study was to evaluate the potential mechanisms through which CPLA inhibits N-nitrosomethyl­benzylamine (NMBA)‑induced rat esophageal tumorigenesis. We treated F344 rats subcutaneously with the esophageal carcinogen NMBA (0.5 mg/kg body weight) and intramuscularly with CPLA (20 mg/kg), 3 times a week for 5 weeks. Rats were then sacrificed at weeks 9, 15 or 25, esophageal tissues were collected and tumor data were recorded. To investigate the mechanisms by which CPLA modulates tumorigenesis in esophagus, we evaluated the protein expression of glycogen synthase kinase-3β (GSK‑3β) and β‑catenin and the gene expression of c‑myc. CPLA significantly (P<0.05) reduced the incidence of esophageal tumors observed at 25 weeks from 93.3% in NMBA-treated controls to 33.3% in the NMBA- and CPLA-treated rats. CPLA reduced β‑catenin and c‑myc expression, but increased GSK‑3β expression, in preneoplastic lesions of the esophagus. These results suggest a novel tumor-suppressive role of CPLA through the activation of GSK‑3β expression and the inhibition of β‑catenin and c-myc expression. Therefore, CPLA is a potential therapeutic candidate for esophageal squamous cell carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Blot WJ and McLaughlin JK: The changing epidemiology of esophageal cancer. Semin Oncol. 26:2–8. 1999.PubMed/NCBI

2 

American Cancer Society. Cancer facts and figures, 2005. Atlanta, GA: American Cancer Society; 2005

3 

Zou XN, Chen WQ, Zhang SW, Li LD, Lu FZ and Chen YH: An analysis of esophageal cancer incidence and mortality from 30 cancer registries in China, 1998–2002. Chin Cancer. 161:142–146. 2007.

4 

Stoner GD and Gupta A: Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis. 22:1737–1746. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Kakizoe T: Chemoprevention of cancer - focusing on clinical trials. Jpn J Clin Oncol. 33:421–442. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Cragg GM, Grothaus PG and Newman DJ: Impact of natural products on developing new anti-cancer agents. Chem Rev. 109:3012–3043. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Koehn FE and Carter GT: The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 4:206–220. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Mann J: Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer. 2:143–148. 2002. View Article : Google Scholar : PubMed/NCBI

9 

National Committee of Pharmacopoeia. Pharmacopoeia of the People’s Republic of China. Chemical Industry Publishing Company; Beijing, China: pp. 1812005, (In Chinese).

10 

Itokawa H, Xu JP and Takeya K: Studies on chemical constituents of antitumor fraction from Periploca sepium. V Structures of new pregnane glycosides, periplocosides J, K, F and O. Chem Pharm Bull. 36:4441–4446. 1998.PubMed/NCBI

11 

Zhang J, Shan BE and Liu GS: Apoptosis induced by ethyl acetate extract from Cortex periplocae in human breast cancer cell line MCF-7. Tumor. 26:418–421. 2006.(in Chinese).

12 

Zhao LM, Shan BE, Ai J, Ren FZ and Lian YS: Effects of periplocin from Cortex periplocae on proliferation of human esophageal carcinoma cells TE-13 and related mechanisms. Tumor. 28:203–206. 2008.(in Chinese).

13 

Polakis P: The oncogenic activation of beta-catenin. Curr Opin Genet Dev. 9:15–21. 1999. View Article : Google Scholar

14 

Waltzer L and Bienz M: The control of beta-catenin and TCF during embryonic development and cancer. Cancer Metastasis Rev. 18:231–246. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Behrens J: Control of beta-catenin signaling in tumor development. Ann NY Acad Sci. 910:21–33. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Lv J, Cao XF, Ji L, Zhu B, Tao L and Wang DD: Association of Wnt1/beta-catenin with clinical pathological characteristics and prognosis of esophageal squamous cell carcinoma. Genet Test Mol Biomarkers. 14:363–369. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, Park K, Wang H, Peng Y, Jiang W and He TC: Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets. 4:653–671. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A and Nakayama K: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18:2401–2410. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X and He X: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 108:837–847. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Nelson WJ and Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483–1487. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Moon RT, Bowerman B, Boutros M and Perrimon N: The promise and perils of Wnt signaling through beta-catenin. Science. 296:1644–1646. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Akiyama T: Wnt/beta-catenin signaling. Cytokine Growth Factor Rev. 11:273–282. 2000. View Article : Google Scholar

23 

Takahashi-Yanaga F and Sasaguri T: Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs. J Pharmacol Sci. 109:179–183. 2009. View Article : Google Scholar

24 

Xiang YY, Wang DY, Tanaka M, Igarashi H, Kamo T, Shen Q, Sugimura H and Kino I: Efficient and specific induction of esophageal tumors in rats by precursors of N-nitrososarcosine ethyl ester. Pathol Int. 45:415–421. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Wang L, Lu A, Liu X, Sang M, Shan B, Meng F, Cao Q and Ji X: The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. Oncol Rep. 26:1149–1156. 2011.PubMed/NCBI

26 

Osterheld MC, Bian YS, Bosman FT, Benhatter J and Fontolliet C: Beta-catenin expression and its association with prognostic factors in adenocarcinoma developed in Barrett esophagus. Am J Clin Pathol. 117:451–456. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Wu D and Pan W: GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci. 35:161–168. 2010. View Article : Google Scholar : PubMed/NCBI

28 

He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW: Identification of c-myc as a target of the APC pathway. Science. 281:1509–1512. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Giles RH, van Es JH and Clevers H: Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta. 1653:1–24. 2003.PubMed/NCBI

30 

Situ DR, Hu Y, Zhu ZH, Wang J, Long H and Rong TH: Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma. World J Gastroenterol. 16:5195–5202. 2010.

31 

Yang F, Zeng Q, Yu G, Li S and Wang CY: Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal. 18:679–687. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Goto M, Mitra RS, Liu M, Lee J, Henson BS, Carey T, Bradford C, Prince M, Wang CY, Fearon ER and D’Silva NJ: Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res. 16:65–76. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Tsai YP, Yang MH, Huang CH, Chang SY, Chen PM, Liu CJ, Teng SC and Wu KJ: Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis. 30:1049–1057. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B and Kinzler KW: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 275:1787–1790. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Dilek FH, Topak N, Tokyol C, Akbulut G and Dilek ON: β-Catenin and its relation to VEGF and cyclin D1 expression in pT3 rectosigmoid cancers. Turk J Gastroenterol. 21:365–371. 2010.

36 

DasGupta R, Kaykas A, Moon RT and Perrimon N: Functional genomic analysis of the Wnt-wingless signaling pathway. Science. 308:826–833. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Saifo MS, Rempinski DR Jr, Rustum YM and Azrak RG: Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers. Mol Cancer. 9:310–320. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Paul S and Dey A: Wnt signaling and cancer development: therapeutic implication. Neoplasma. 55:165–176. 2008.PubMed/NCBI

39 

Ma C, Wang J, Gao Y, Gao TW, Chen G, Bower KA, Odetallah M, Ding M, Ke Z and Luo J: The role of glycogen synthase kinase 3beta in the transformation of epidermal cells. Cancer Res. 67:7756–7764. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Wang W, Xue L and Wang P: Prognostic value of β-catenin, c-myc, and cyclin D1 expressions in patients with esophageal squamous cell carcinoma. Med Oncol. 28:163–169. 2011.

41 

Albihn A, Johnsen JI and Henriksson MA: MYC in oncogenesis and as a target for cancer therapies. Adv Cancer Res. 107:163–224. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Lu A, Meng F, Cao Q and Shan B: Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis. Oncol Lett 4: 231-236, 2012.
APA
Wang, L., Lu, A., Meng, F., Cao, Q., & Shan, B. (2012). Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis. Oncology Letters, 4, 231-236. https://doi.org/10.3892/ol.2012.717
MLA
Wang, L., Lu, A., Meng, F., Cao, Q., Shan, B."Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis". Oncology Letters 4.2 (2012): 231-236.
Chicago
Wang, L., Lu, A., Meng, F., Cao, Q., Shan, B."Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis". Oncology Letters 4, no. 2 (2012): 231-236. https://doi.org/10.3892/ol.2012.717
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Lu A, Meng F, Cao Q and Shan B: Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis. Oncol Lett 4: 231-236, 2012.
APA
Wang, L., Lu, A., Meng, F., Cao, Q., & Shan, B. (2012). Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis. Oncology Letters, 4, 231-236. https://doi.org/10.3892/ol.2012.717
MLA
Wang, L., Lu, A., Meng, F., Cao, Q., Shan, B."Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis". Oncology Letters 4.2 (2012): 231-236.
Chicago
Wang, L., Lu, A., Meng, F., Cao, Q., Shan, B."Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine‑induced rat esophageal tumorigenesis". Oncology Letters 4, no. 2 (2012): 231-236. https://doi.org/10.3892/ol.2012.717
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team