Multiple cervical ganglioneuroma: A case report and review of the literature

Ma,Junli; Liang,Limin; Liu,Hongchen

doi:10.3892/ol.2012.767

Multiple cervical ganglioneuroma: A case report and review of the literature

Authors:
- Junli Ma
- Limin Liang
- Hongchen Liu
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Affiliations: Department of Stomatology, The General Hospital of the People's Liberation Army, Beijing 100853, P.R. China
Published online on: June 21, 2012 https://doi.org/10.3892/ol.2012.767
Pages: 509-512

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Abstract

Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow‑growing mass, and multiple occurrences in the cervical region are extremely rare. Here, we report a case of massive multiple cervical GN in a 4‑year‑old girl, and review cases of cervical GN that have been reported in the past 10 years. The results demonstrated that cervical GN, compared to other sites, is seldom secretory. The signs and symptoms of cervical GN are unspecific; the ultimate diagnosis of GN depends on pathological examination. Fine-needle aspiration biopsy has limited value in diagnosis. Surgical excision is the treatment of choice and the prognosis is excellent even in cases where complete excision cannot be achieved. Furthermore, GNs should be considered in patients with multiple masses in the neck.

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1	Shotton JC, Milton CM and Allen JP: Multiple ganglioneuroma of the neck. J Laryngol Otol. 106:277–278. 1992. View Article : Google Scholar : PubMed/NCBI
2	Miyakoshi N, Hongo M, Kasukawa Y, Misawa A and Shimada Y: Bilateral and symmetric C1–C2 dumbbell ganglioneuromas associated with neurofibromatosis type 1 causing severe spinal cord compression. Spine J. 10:e11–e15. 2010.
3	Bacci C, Sestini R, Ammannati F, Bianchini E, Palladino T, Carella M, Melchionda S, Zelante L and Papi L: Multiple spinal ganglioneuromas in a patient harboring a pathogenic NF1 mutation. Clin Genet. 77:293–297. 2010. View Article : Google Scholar : PubMed/NCBI
4	Zebing Z, Jianwei S, Yan C and Yan G: Clinicopathological characteristics of neck ganglioneuroma. Oral Med Pathol. 12:131–134. 2008. View Article : Google Scholar
5	Patterson AR, Barker CS, Loukota RA and Spencer J: Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma. Int J Oral Maxillofac Surg. 38:196–198. 2009. View Article : Google Scholar : PubMed/NCBI
6	Ozluoglu LN, Yilmaz I, Cagici CA, Bal N and Erdogan B: Ganglioneuroma of the internal auditory canal: a case report. Audiol Neurootol. 12:160–164. 2007. View Article : Google Scholar : PubMed/NCBI
7	Leonardis M, Sperb D, Alster C, Campisi C and Herter NT: Ganglioneuroma of the neck, masquerading as a goiter. Eur J Surg Oncol. 29:929–930. 2003. View Article : Google Scholar : PubMed/NCBI
8	Cannady SB, Chung BJ, Hirose K, Garabedian N, Van Den Abbeele T and Koltai PJ: Surgical management of cervical ganglioneuromas in children. Int J Pediatr Otorhinolaryngol. 70:287–294. 2006. View Article : Google Scholar : PubMed/NCBI
9	Ponce-Camacho MA, Diaz de Leon-Medina R, Miranda-Maldonado I, Garza-Guajardo R, Hernandez-Salazar J and Barboza-Quintana O: A 5-year-old girl with a congenital ganglioneuroma diagnosed by fine needle aspiration biopsy: a case report. Cytojournal. 5:52008.PubMed/NCBI
10	Kolte SS: Ganglioneuroma presenting as a neck mass diagnosed by fine needle aspiration cytology. Cytopathology. 22:205–206. 2011. View Article : Google Scholar : PubMed/NCBI
11	Müller A, Förster G, Behrendt W and Kosmehl H: Headache as an unusual presenting symptom of retropharyngeal ganglioneuroma. Acta Otolaryngol. 122:565–568. 2002.PubMed/NCBI
12	Kaufman MR, Rhee JS, Fliegelman LJ and Costantino PD: Ganglioneuroma of the parapharyngeal space in a pediatric patient. Otolaryngol Head Neck Surg. 124:702–704. 2001. View Article : Google Scholar : PubMed/NCBI
13	Choi HY, Lee JH, Park JM and Shin MK: Orbital ganglioneuroma in a young healthy person. Arch Ophthalmol. 127:223–225. 2009.PubMed/NCBI
14	Katilmis H, Ozturkcan S, Adadan I, Ozdemir I, Algin H and Tunakan M: Cervical ganglioneuroma. Int J Pediatr Otorhinolaryngeal Extra. 1:157–159. 2006. View Article : Google Scholar
15	Gary C, Robertson H, Ruiz B, Zuzukin V and Walvekar RR: Retropharyngeal ganglioneuroma presenting with neck stiffness: report of a case and review of literature. Skull Base. 20:371–374. 2010. View Article : Google Scholar : PubMed/NCBI
16	Cannon TC, Brown HH, Hughes BM, Wenger AN, Flynn SB and Westfall CT: Orbital ganglioneuroma in a patient with chronic progressive proptosis. Arch Ophthalmol. 122:1712–1714. 2004. View Article : Google Scholar : PubMed/NCBI
17	Friedlander PL, Hunt JP and Palacios E: Ganglioneuroma of the neck. Ear Nose Throat J. 81:4352002.
18	Geoerger B, Hero B, Harms D, Grebe J, Scheidhauer K and Berthold F: Metabolic activity and clinical features of primary ganglioneuromas. Cancer. 91:1905–1913. 2001. View Article : Google Scholar : PubMed/NCBI
19	Ichikawa T, Ohtomo K, Araki T, Fujimoto H, Nemoto K, Nanbu A, Onoue M and Aoki K: Ganglioneuroma: computed tomography and magnetic resonance features. Br J Radiol. 69:114–121. 1996. View Article : Google Scholar : PubMed/NCBI
20	Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK and Castleberry RP: The international neuroblastoma pathology classification (the Shimada system). Cancer. 86:364–372. 1999. View Article : Google Scholar : PubMed/NCBI
21	Retrosi G, Bishay M, Kiely EM, Sebire NJ, Anderson J, Elliott M, Drake DP, Coppi P, Eaton S and Pierro A: Morbidity after ganglioneuromaexcision: is surgery necessary? Eur J Pediatr Surg. 21:33–37. 2011. View Article : Google Scholar : PubMed/NCBI