Specific organ metastases and survival in small cell lung cancer

  • Authors:
    • Kensuke Nakazawa
    • Koichi Kurishima
    • Tomohiro Tamura
    • Katsunori Kagohashi
    • Hiroichi Ishikawa
    • Hiroaki Satoh
    • Nobuyuki Hizawa
  • View Affiliations

  • Published online on: July 9, 2012     https://doi.org/10.3892/ol.2012.792
  • Pages: 617-620
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Abstract

The aim of our retrospective study was to evaluate the clinicopathological features associated with distant metastasis from small cell lung cancer (SCLC). We reviewed patients diagnosed with SCLC metastasis at the time of presentation between 1999 and 2010. Among the consecutive 251 SCLC patients diagnosed, 152 (60.6%) patients had distant metastasis, of which 20.3, 18.3, 15.5, 10.0 and 6.0% of patients had liver, bone, brain, lung and adrenal gland metastasis, respectively. In a multivariate analysis using Cox's proportional hazards model, we identified that liver, bone and brain metastasis as well as the presence of pleural and/or pericardial fluids were unfavorable prognostic factors. However, lung, adrenal gland and extrathoracic lymph node metastasis were not statistically significant prognostic factors. With regard to the treatment of SCLC patients, particularly those with liver, bone and brain metastasis or pleural and/or pericardial fluids, we should take the metastasizing organs into consideration.
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October 2012
Volume 4 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nakazawa K, Kurishima K, Tamura T, Kagohashi K, Ishikawa H, Satoh H and Hizawa N: Specific organ metastases and survival in small cell lung cancer. Oncol Lett 4: 617-620, 2012
APA
Nakazawa, K., Kurishima, K., Tamura, T., Kagohashi, K., Ishikawa, H., Satoh, H., & Hizawa, N. (2012). Specific organ metastases and survival in small cell lung cancer. Oncology Letters, 4, 617-620. https://doi.org/10.3892/ol.2012.792
MLA
Nakazawa, K., Kurishima, K., Tamura, T., Kagohashi, K., Ishikawa, H., Satoh, H., Hizawa, N."Specific organ metastases and survival in small cell lung cancer". Oncology Letters 4.4 (2012): 617-620.
Chicago
Nakazawa, K., Kurishima, K., Tamura, T., Kagohashi, K., Ishikawa, H., Satoh, H., Hizawa, N."Specific organ metastases and survival in small cell lung cancer". Oncology Letters 4, no. 4 (2012): 617-620. https://doi.org/10.3892/ol.2012.792