Management of giant ovarian teratoma: A case series and review of the literature

Ye,Long-Yun; Wang,Jing-Jing; Liu,Da-Ren; Ding,Guo-Ping; Cao,Li-Ping

doi:10.3892/ol.2012.793

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

Management of giant ovarian teratoma: A case series and review of the literature

Authors:
- Long-Yun Ye
- Jing-Jing Wang
- Da-Ren Liu
- Guo-Ping Ding
- Li-Ping Cao
View Affiliations / Copyright

Affiliations: Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, P.R. China
Pages: 672-676
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Published online on: July 9, 2012

https://doi.org/10.3892/ol.2012.793
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Abstract

The management of ovarian teratomas in normal conditions is well established, but in rare giant cases (tumor diameter over 15 cm), the choice of management, such as laparotomic or laparoscopic approaches, are controversial and may be therapeutically challenging for surgeons. The aims of the current study were to analyze the clinical features of giant ovarian teratoma and to discuss its management. The clinical data of 330 patients with giant ovarian teratoma (of whom 1 patient was treated by the authors and 329 were admitted to the Second Affiliated Hospital of Zhejiang University Medical College between January 1st 2000 and December 31st 2010) were reviewed and analyzed. The patients had an age range of 6 to 83 years and a mean tumor size of 24.9±7.1 cm. Of the 330 patients, 102 (30.9%) were asymptomatic and the majority (69.1%, 228/330) reported symptoms. There were more patients in the laparotomic group than the laparoscopic group, especially for the emergency cases (5.5 vs. 0%, P<0.05). Accidental cyst rupture was more frequent when a laparoscopic approach was used (31.5 vs. 19.6%, P<0.05). These results suggest that laparotomic resection may be preferred for the en bloc mass removal, adequate abdominal cavity irrigation and avoidance of accidental mass rupture in the management of giant ovarian teratomas. Familiarity with the imaging features of giant ovarian teratomas effectively aids preoperative diagnosis and differentiation.

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1.	DJ ChoiEC WallaceAE FraireD BaiyeeBest cases from the AFIP: intrarenal teratomaRadiographics25481485200510.1148/rg.25204515315798064
2.	JT Comerci JrF LicciardiPA BerghC GregoriJL BreenMature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literatureObstet Gynecol84222819948008317
3.	E ShalevM BustanS RomanoY GoldbergI Ben-ShlomoLaparoscopic resection of ovarian benign cystic teratomas: experience with 84 casesHum Reprod1318101812199810.1093/humrep/13.7.18109740429
4.	W KondoN BourdelB CotteX TranR BotchorishviliK JardonB RabischongJL PoulyG MageM CanisDoes prevention of intraperitoneal spillage when removing a dermoid cyst prevent granulomatous peritonitis?BJOG11710271030201010.1111/j.1471-0528.2010.02580.x20465557
5.	PP KooningsK CampbellDR Mishell JrDA GrimesRelative frequency of primary ovarian neoplasms: a 10-year reviewObstet Gynecol7492192619892685680
6.	F StellaF DavoliGiant mediastinal mature teratoma with increased exocrine pancreatic activity presenting in a young woman: a case reportJ Med Case Reports5238201110.1186/1752-1947-5-23821703035
7.	MS DolanSC BoulangerJR SalamehLaparoscopic management of giant ovarian cystJSLS10254256200616882432
8.	B CaspiZ AppelmanD RabinersonY ZalelT TulandiZ ShohamThe growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal womenFertil Steril68501505199710.1016/S0015-0282(97)00228-89314922
9.	L HibbardAdnexal torsionAm J Obstet Gynecol152456461198510.1016/S0002-9378(85)80157-54014339
10.	F GhaemmaghamiF AbbasiAG AbadiA favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovaryJ Gynecol Oncol20257259200910.3802/jgo.2009.20.4.25720041106
11.	C CaldasJ SitzmannCL TrimbleWP McGuire IIISynchronous mature teratomas of the ovary and liver: a case presenting 11 years following chemotherapy for immature teratomaGynecol Oncol4738539019921473754
12.	S GuerrieroG MallariniS AjossaA RisalvatoR SattaV MaisM AngiolucciGB MelisTransvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal womenUltrasound Obstet Gynecol9339343199710.1046/j.1469-0705.1997.09050339.x
13.	JN BuyMA GhossainAA MossM BazotM DoucetD HugolJB TrucP PoitoutJ EcoiffierCystic teratoma of the ovary: CT detectionRadiology171697701198910.1148/radiology.171.3.27177412717741
14.	FY TengD MuzsnaiR PerezF MazdisnianA RossJW SayreA comparative study of laparoscopy and colpotomy for the removal of ovarian dermoid cystsObstet Gynecol8710091013199610.1016/0029-7844(96)00061-08649681
15.	HA SalemLaparoscopic excision of large ovarian cystsJ Obstet Gynecol Res28290294200210.1046/j.1341-8076.2002.00057.x12512924
16.	FM HowardSurgical management of benign cystic teratoma. Laparoscopy vs. laparotomyJ Reprod Med4049549919957473436
17.	E ShalevD PelegLaparoscopic treatment of adnexal torsionSurg Gynecol Obstet17644845019938480267
18.	EK OutwaterES SiegelmanJL HuntOvarian teratomas: tumor types and imaging characteristicsRadiographics21475490200110.1148/radiographics.21.2.g01mr0947511259710
19.	EM DulmetP MacchiariniB SucJM VerleyGerm cell tumors of the mediastinum. A 30-year experienceCancer721894190119937689921
20.	L Dos SantosE MokA IasonosK ParkRA SoslowC AghajanianK AlektiarRR BarakatNR Abu-RustumSquamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literatureGynecol Oncol105321324200717240432
21.	U GöbelG CalaminusJ EngertTeratomas in infancy and childhoodMed Pediatr Oncol318151998
22.	G CandelaL Di LiberoS VarrialeF ManettaS NapolitanoG ScettaD EspositoV SciasciaL SantiniHemoperitoneum caused by the rupture of a giant ovarian teratoma in a 9-year-old female. Case report and literature reviewAnn Ital Chir80141144200919681297
23.	M Lo CurtoP D’AngeloG CecchettoMature and immature teratomas: results of the first paediatric Italian studyPediatr Surg Int23315322200717333214
24.	E MoskovicT JoblingC FisherE WiltshawC ParsonsRetroconversion of immature teratoma of the ovary: CT appearancesClin Radiol43402408199110.1016/S0009-9260(05)80570-72070582

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Management of giant ovarian teratoma: A case series and review of the literature

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